GABA_A receptor partially mediated propofol-induced hyperalgesia at ventrolateral periaqueductal gray(vlPAG) of rats / 中国药理学通报
Chinese Pharmacological Bulletin
; (12)1987.
Article
em Zh
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| ID: wpr-558158
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ABSTRACT
Aim To observe the effects of propofol on nociceptive response at ventrolateral periaqueductal gray(vlPAG) of rats and the possible role of GABA_A receptor in this prosses.Methods Sprague-Dawley(SD) female rats were randomized into each group.Bicuculline and propofol were microinjected into ventrolateral periaqueductal gray(vlPAG).The noxious response was evaluated by hot plate and formalin test.Fos-like immunoreactivity(FLI) neurons expressed in spinal dorsal horn(DH) induced by formalin intraplantar injection(sc) of one hindpaw were used as a neuroactive marker to observe the effects of propofol on the noxious transmission in DH.Results In hot-plate test,the hyperalgesia induced by propofol(10 g?L~(-1)) vlPAG microinjection was significantly antagonized about(70%),(71%) at 10 and 20 min after (bicu-)culline(25 mg?L~(-1)) vlPAG microinjection(P
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Base de dados:
WPRIM
Tipo de estudo:
Clinical_trials
Idioma:
Zh
Revista:
Chinese Pharmacological Bulletin
Ano de publicação:
1987
Tipo de documento:
Article