Effects of progesterone on morphine-induced conditioned place preference and levels of ?-receptor in hippocampus and striatum / 中国药理学通报

ABSTRACT

Aim To investigate the effects of progesterone on morphine rewarding effect and levels of ?-receptor in hippocampus and striatum.Methods 32 male SD rats were designated to 4 groups randomly with 8 in each,including blank control group,morphine group,progesterone group and progesterone plus morphine group.Conditioned place preference(CPP) test was used to investigate the morphine rewarding effect,and immunohistochemistry was established to determine the levels of ?-receptor in hippocampus and striatum.Results Compared with those of blank control group,5 mg?kg-1 morphine successfully induced the formation of CPP(P