The study of radiology in the experiment of repairing bone defects with nano-hydroxyapatite and polyamide-66 composite / 重庆医科大学学报

ABSTRACT

Objective:Tostudy the MRI with X-ray in the ability of bony generation by the way of the experiment of repairing bone defects with n-HA/PA66. Methods:30 New Zealand rabbits were avalued whose condyle of tibia in one side was performed boring which was 3mm diameter and 5mm depth with n-HA/PA66 composite implanting. The specimens were taken respectively in different times2nd 4th 6th 8th 12th week after surgery,and were examined by the methods of plain roentgenography、histology and magnetic resonance imaging. Results:(1)MRI and X-rayFrom the 4th week,n-HA/PA66 composite had the poor defined border and the signal inter-material had become more variform,more obvious enhancement,at the same time in the X-ray,there were more and more bony generation(.2)The histology showed that a layer of interface membrane forming. From the 4th week,The interface membrane had been widest and the number of cells was increasing. Till the 12th week,there were some bone trabecula formed and the HA were separated into small islands,more osteoclasts appeared. Conclusion:The experimental results showthat the perfect radiology technique is useful to predict the bone transplantation. Furthermore it is easy to operate in clinical setting,and the n-HA/PA66 Composite has the attribute of good biocompatility and osteoconductibity,which can be manifested by plain roentgenography and magnetic resonance imaging.