Study of Relationship between Hsp70 and Endothelial Activation in Placental Vascular Diseases / 实用妇产科杂志
Journal of Practical Obstetrics and Gynecology
; (12): 222-224,前插1, 2010.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-597460
Biblioteca responsável:
WPRO
ABSTRACT
Objective:
The pathogenesis of placental vascular disease(PVD) was further investigated. MethodePVD group (study group) and normal pregnancy (control group) were recruited. Two-channel mi-croarray technique was applied to screen the most differently expressive genes of human genome, and veri-fied the different expressions in mRNA and protein levels by quantitative PCR and Westem-blot, also local-ized the expression of different genes in placental tissue by immunohistochemistry. ReeultsHspA6 and Hs-pA1A had extremely higher expression in placentas with PVD than normal pregnancy. These genes both en-coded Hsp70. Hsp70 was mostly expressed in endothelial and smooth muscle cells of placental microves-ssls. The expression of Hsp70 mRNA and protein were up-regulated in placental tissue and microvascular endothelial cells from PVD group compared with normal pregnancy ( P <0.05) ;The expression of Hsp70 mR-NA and protein had negative correlation with infant birth weight ( P < 0.05). ConclueioneHsp70 was associ-ated with endothelial activation in the pathogenesis of PVD by initiating an innate immune response and in-flammatory reaction.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Journal of Practical Obstetrics and Gynecology
Ano de publicação:
2010
Tipo de documento:
Artigo