The renin-angiotensin system and aging in the kidney
The Korean Journal of Internal Medicine
; : 291-295, 2014.
Article
em En
| WPRIM
| ID: wpr-62923
Biblioteca responsável:
WPRO
ABSTRACT
Aging is associated with progressive functional deterioration and structural changes in the kidney. Changes in the activity or responsiveness of the renin-angiotensin system (RAS) occur with aging. RAS changes predispose the elderly to various fluid and electrolyte imbalances as well as acute kidney injury and chronic kidney disease. Among the multiple pathways involved in renal aging, the RAS plays a central role. This review summarizes the association of the RAS with structural and functional changes in the aging kidney and age-related renal injury, and describes the underlying mechanisms of RAS-related renal aging. An improved understanding of the renal aging process may lead to better individualized care of the elderly and improved renal survival in age-related diseases.
Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Prognóstico
/
Sistema Renina-Angiotensina
/
Envelhecimento
/
Fatores de Risco
/
Fatores Etários
/
Injúria Renal Aguda
/
Glucuronidase
/
Rim
/
Nefropatias
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
The Korean Journal of Internal Medicine
Ano de publicação:
2014
Tipo de documento:
Article