Effect of Bailing capsule on the patients with stable chronic obstructive pulmonary disease / 新乡医学院学报

ABSTRACT

Objective To investigate the effect and mechanism of Bailing capsule on the patients with stable chronic obstructive pulmonary disease (COPD).Methods A total of 100 patients with more than two weeks of stable COPD were selected from January 2013 to June 2016 in the Department of Respiratory Medicine,the First Affiliated Hospital of Xinxiang Medical University.The patients were randomly divided into the control group and the observation group,with 50 cases in each group.The patients in the control group were treated with tiotropium bromide powder for inhalation,and the patients in the observation group were treated with Bailing capsule orally on the basis of tiotropium bromide powder for inhalation,the patients in the two groups were treated for 12 months.The clinical effect and the average number of acute exacerbations within one year were compared between the two groups;and the level of serum amyloid A (SAA) were compared between the two groups before treatment and 3,6 and 12 months after treatment.Results The total effective rate in the observation group (84.0％) was significantly higher than that in the control group (72.0％)after 12 months of treatment (x2 =4.097,P ＜ 0.05).The average number of acute exacerbations in the observation group within one year was significantly less than that in the control group (P ＜ 0.01).There was no significant difference in serum SAA level between the two groups before treatment and 3 months after treatment (P ＞ 0.05).The serum SAA level in the observation group was significantly lower than that in the control group at the time points of 6 and 12 months after treatment (P ＜ 0.05).There was no significant difference in serum SAA level between before treatment and 3 months after treatment in the two groups (P ＞ 0.05).The serum SAA level at 6 and 12 months after treatment was significantly lower than that before treatment and 3 months after treatment in the two groups (P ＜ 0.05).The serum SAA level at 12 months of treatment was significantly lower than that at 6 months of treatment in the two groups (P ＜ 0.05).Conclusion Bailing capsule can inhibit the inflammatory reaction of COPD patients by interfering with the secretion of serum SAA,so as to improving the clinical manifestations of COPD patients and reducing the acute attack of COPD.