Advances in mechanisms of microglial function on demyelination and remyelination in EAE model / 中国免疫学杂志
Chinese Journal of Immunology
; (12): 602-608, 2018.
Article
em Zh
| WPRIM
| ID: wpr-702782
Biblioteca responsável:
WPRO
ABSTRACT
Inflammatory cells infiltration and demyelination in the central nervous system (CNS) are the main pathological characteristics of multiple sclerosis(MS),an autoimmune disease in the CNS.Most of the related pathological studies are carried out in the animal model experimental autoimmune encephalomyelitis(EAE).Microglia(MG) are the primary immune effector cells of the CNS and their activation can play complex roles in demyelination and remyelination during EAE.In detail,M1 phenotype is an important cause of demyelination and detrimental to remyelination while M2 phenotype can promote remyelination and inhibit demyelination.In this review,we not only focus on advances in the direct mechanisms of microglial function on demyelination and remyelination in EAE model,also the indirect mechanisms by astrocytes.
Texto completo:
1
Base de dados:
WPRIM
Tipo de estudo:
Prognostic_studies
Idioma:
Zh
Revista:
Chinese Journal of Immunology
Ano de publicação:
2018
Tipo de documento:
Article