Design, synthesis and biological evaluation of pyridine-based IRAK4 inhibitors / 中国药科大学学报
Journal of China Pharmaceutical University
; (6): 670-674, 2017.
Article
em Zh
| WPRIM
| ID: wpr-704301
Biblioteca responsável:
WPRO
ABSTRACT
Based on the known IRAK4 inhibitors MK-32 and AU-5,we designed and synthesized 12 pyridine-based target compounds by adopting open-ring and hybrid strategies,and combining molecular docking technology.The bioassays determined by radioisotope labeling demonstrated that the target compounds displayed good inhibitory activity against IRAK4.Among them,the IC50 value of 5 compounds was less than 1 μmol/L,suggesting that these compounds may be candidates for further investigation.
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Base de dados:
WPRIM
Idioma:
Zh
Revista:
Journal of China Pharmaceutical University
Ano de publicação:
2017
Tipo de documento:
Article