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Prevalence of dynapenic obesity and sarcopenic obesity and their associations with cardiovascular disease risk factors in peritoneal dialysis patients
Artigo em Inglês | WPRIM (Pacífico Ocidental) | ID: wpr-718613
Biblioteca responsável: WPRO
ABSTRACT

BACKGROUND:

Dynapenic obesity and sarcopenic obesity increase cardiovascular disease (CVD) and mortality in nonuremic patients. The present study was designed to determine the prevalence of dynapenic obesity and sarcopenic obesity and their associations with CVD risk factors in peritoneal dialysis (PD) patients.

METHODS:

All eligible PD patients in Tehran peritoneal dialysis centers were included in this cross-sectional study. Skeletal muscle mass and fat mass were assessed using bioelectrical impedance analysis. Muscle strength and physical performance were determined using hand grip strength and a 4-meter walk gait speed test, respectively. In addition, a 5-mL blood sample was obtained from each patient.

RESULTS:

The prevalence of dynapenic obesity and sarcopenic obesity were 11.4% and 3.8% in PD patients, respectively. Serum high-sensitive C-reactive protein (hs-CRP), soluble intercellular adhesion molecule type 1, triglyceride, total cholesterol, and low-density lipoprotein cholesterol were significantly higher in PD patients with dynapenic obesity than in dynapenic nonobese and nondynapenic nonobese patients. Similarly, serum concentrations of CVD risk factors in PD patients with sarcopenic obesity were higher than in nonsarcopenic nonobese patients, but these differences were statistically significant only for serum hs-CRP and triglyceride. In addition, muscle strength and skeletal muscle mass percentage were negatively associated with markers of inflammation and dyslipidemia, whereas body fat percentage was positively associated with these CVD risk factors.

CONCLUSION:

This study indicates that although the prevalence of dynapenic obesity and sarcopenic obesity are relatively low in PD patients, these disorders may be associated with CVD risk factors.
Assuntos

Texto completo: Disponível Contexto em Saúde: ODS3 - Meta 3.4 Reduzir as mortes prematuras devido doenças não transmissíveis Problema de saúde: Doença Cardiovascular / Doenças do Sistema Endócrino / Obesidade / Outras Neoplasias Malignas Base de dados: WPRIM (Pacífico Ocidental) Assunto principal: Triglicerídeos / Proteína C-Reativa / Doenças Cardiovasculares / Tecido Adiposo / Colesterol / Prevalência / Estudos Transversais / Fatores de Risco / Mortalidade / Diálise Peritoneal Tipo de estudo: Estudo de etiologia / Estudo observacional / Estudo de prevalência / Estudo prognóstico / Fatores de risco Limite: Humanos Idioma: Inglês Revista: Kidney Research and Clinical Practice Ano de publicação: 2018 Tipo de documento: Artigo
Texto completo: Disponível Contexto em Saúde: ODS3 - Meta 3.4 Reduzir as mortes prematuras devido doenças não transmissíveis Problema de saúde: Doença Cardiovascular / Doenças do Sistema Endócrino / Obesidade / Outras Neoplasias Malignas Base de dados: WPRIM (Pacífico Ocidental) Assunto principal: Triglicerídeos / Proteína C-Reativa / Doenças Cardiovasculares / Tecido Adiposo / Colesterol / Prevalência / Estudos Transversais / Fatores de Risco / Mortalidade / Diálise Peritoneal Tipo de estudo: Estudo de etiologia / Estudo observacional / Estudo de prevalência / Estudo prognóstico / Fatores de risco Limite: Humanos Idioma: Inglês Revista: Kidney Research and Clinical Practice Ano de publicação: 2018 Tipo de documento: Artigo
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