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Efficacy of Alpha Blocker Treatment According to the Degree of Intravesical Prostatic Protrusion Detected by Transrectal Ultrasonography in Patients with Benign Prostatic Hyperplasia
Article em En | WPRIM | ID: wpr-71964
Biblioteca responsável: WPRO
ABSTRACT
PURPOSE: To analyze the effectiveness of tamsulosin 0.2 mg once daily for 3 months according to the degree of intravesical prostatic protrusion (IPP) in patients with benign prostatic hyperplasia (BPH). MATERIALS AND METHODS: A total of 134 BPH patients over 40 years of age treated with tamsulosin 0.2 mg between January 2007 and January 2009 were enrolled retrospectively. The patients were classified into three groups according to the degree of IPP: below 5 mm (group A), between 5 and 10 mm (group B), and over 10 mm (group C). Prostate volume, prostate-specific antigen (PSA), prostatic urethral length (PUL), and prostatic adenoma urethral length (PAUL) were evaluated before treatment. International Prostate Symptom Score and Quality of Life (IPSS/QoL), maximal urine flow rate (Qmax), and postvoid residual (PVR) volume were measured before treatment, and improvement in the three groups was compared after 3 months. RESULTS: The mean age of the patients was 65.01+/-7.38 years. Mean IPPs were 0.90+/-1.39 mm (group A, n=90), 6.92+/-1.10 mm (group B, n=24), and 16.60+/-4.06 mm (group C, n=20). Prostate volume, PUL, PAUL, PSA, Qmax, and PVR showed significant correlations with IPP (p0.05). Comparison of parameters before and after 3 months showed that medication improved total IPSS and subscores (p<0.001), QoL (p<0.001), Qmax (p<0.001), and PVR (p=0.030) in group A. In group B, it improved total IPSS (p=0.01), irritative subscore (p<0.001), and obstructive subscore (p=0.03). In group C, only total IPSS (p=0.01) and irritative score (p<0.001) were significantly improved. CONCLUSIONS: Tamsulosin may be more effective in improving symptom scores and Qmax in patients with mild IPP than in those with moderate or severe IPP.
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Texto completo: 1 Base de dados: WPRIM Assunto principal: Próstata / Hiperplasia Prostática / Qualidade de Vida / Sulfonamidas / Estudos Retrospectivos / Antígeno Prostático Específico / Indóis Tipo de estudo: Observational_studies Aspecto: Patient_preference Limite: Humans Idioma: En Revista: Korean Journal of Urology Ano de publicação: 2012 Tipo de documento: Article
Texto completo: 1 Base de dados: WPRIM Assunto principal: Próstata / Hiperplasia Prostática / Qualidade de Vida / Sulfonamidas / Estudos Retrospectivos / Antígeno Prostático Específico / Indóis Tipo de estudo: Observational_studies Aspecto: Patient_preference Limite: Humans Idioma: En Revista: Korean Journal of Urology Ano de publicação: 2012 Tipo de documento: Article