Transforming growth factor-β and renal fibrosis / 生理学报
Acta Physiologica Sinica
; (6): 612-622, 2018.
Article
em Zh
| WPRIM
| ID: wpr-777223
Biblioteca responsável:
WPRO
ABSTRACT
Transforming growth factor-β (TGF-β) is a driving force of renal fibrosis, which may lead to chronic kidney diseases and even end stage renal diseases. By activating canonical and non-canonical signaling pathways, TGF-β promotes the synthesis of extracellular matrix while preventing their degradation. In the injured kidney, TGF-β induces apoptosis, proliferation and fibrotic response of renal cells including epithelial cells, endothelial cells, podocytes, fibroblasts, pericytes and macrophages, and it also promotes transdifferentiation, activation and proliferation of myofibroblasts. Additionally, TGF-β exerts profibrotic effects by interplaying with other signaling pathways like BMP-7, Wnt/β-catenin and MAP kinase. Smad3 is the central pathological gene in renal fibrosis, and epigenetic regulation of TGF-β/Smad3 is a hot topic in kidney field. Although direct targeting TGF-β may cause side effects including tumorigenesis and immune diseases, the therapeutic strategies targeting the balance of downstream Smad3 and Smad7 may prevent or delay the progression of fibrotic kidney disease.
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Patologia
/
Fibrose
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Transdução de Sinais
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Fator de Crescimento Transformador beta
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Epigênese Genética
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Proteína Smad7
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Proteína Smad3
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Nefropatias
/
Metabolismo
Limite:
Humans
Idioma:
Zh
Revista:
Acta Physiologica Sinica
Ano de publicação:
2018
Tipo de documento:
Article