Review of research on dual PI3K-mTOR small molecular inhibitors / 药学实践杂志
Journal of Pharmaceutical Practice
; (6): 332-336,359, 2014.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-790353
Biblioteca responsável:
WPRO
ABSTRACT
Objective The phosphoinositide 3-kinase (PI3K) constituted an important family of lipid kinase enzymes that control a range of cellular proliferation , differentiation and apoptosis through their regulation of a network of signal transduction path -ways, which had emerged as important therapeutic targets in the context of cancer and inflammation .Considerable progress had been made in the discovery and development of small molecular inhibitors targeting PI 3K.Progress in dual PI3K-mTOR inhibitors, a number of which had entered early phase clinical trials over recent years was summarized .
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Journal of Pharmaceutical Practice
Ano de publicação:
2014
Tipo de documento:
Artigo