Synthesis and biological activity of chalcone derivatives as potent activators of Nrf2 / 中国药科大学学报
Journal of China Pharmaceutical University
; (6): 666-672, 2016.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-811879
Biblioteca responsável:
WPRO
ABSTRACT
@#To obtain ARE-Nrf2 potent activators through modifying the structure of the lead compound CPUY191001. 17 compounds were synthesized by aldol condensation, their cytotoxicity were tested using MTT assay, and ARE inductivity of these target compounds were analyzed by luciferase reporter gene assay. The biological evaluation results showed that most synthesized chalcone derivatives nearly had no cytotoxicity, and compounds 2, 3, 10 conducted better activity and in concentration-dependent manner. Compounds 2, 3, 10 are potential agents in the development of anti-inflammatory and chemoprevention, suggesting that compounds 2, 3, 10 are worth for further investigation.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Journal of China Pharmaceutical University
Ano de publicação:
2016
Tipo de documento:
Artigo