Recent research progress in small molecule AMPK direct activators / 中国药科大学学报
Journal of China Pharmaceutical University
; (6): 406-415, 2015.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-811966
Biblioteca responsável:
WPRO
ABSTRACT
@#Type 2 diabetes, an epidemic disorder characterized by high blood glucose level associated with microvascular complications, is one of the main causes of human suffer across the globe, with no effective medicine up to now. AMP-activated protein kinase(AMPK), a highly conserved serine/threonine protein kinase, is a key sensor and regulator of intracellular and whole-body energy metabolism. Small molecule AMPK direct activators have been proven to lower blood-glucose, which is a promising candidate for the treatment of type 2 diabetes. The progress on the research of small molecule AMPK direct activators in recent years is summarized in this paper.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Journal of China Pharmaceutical University
Ano de publicação:
2015
Tipo de documento:
Artigo