Meta analysis of the association of Bisphenol A with obesity in children and adolescents / 中国学校卫生

ABSTRACT

Objective@#To evaluate the relationship between the bisphenol A (BPA) exposure and obesity in children and adolescents with Meta-analysis, and to provide a new idea for prevention and control of obesity.@*Methods@#Reviewer independently searched and screened potentially relevant studies that reported the association between BPA and obesity in children and adolescents through Medline, Web of Science, CBM, CNKI, WANFANG DATA and CQVIP to March 7, 2019. Chi-square based Q test and I 2 statistic were used to assess the heterogeneity. Forest plot was used to display results graphically. Potential publication bias was assessed by the Egger and Begg tests and funnel plot.@*Results@#In total, 13 studies with 3 932 participants met the eligibility criteria, 13 articles were indentified involving 1 046 obesity children and 2 886 normal control children. Overall summary estimates indicated significant positive correlation between urinary BPA and obesity ( SMD =0.26，95% CI =0.01-0.51), and a nonsignificant association between serum BPA and obesity ( SMD =0.07，95% CI =-0.44-0.58). Significant heterogeneity was observed in overall estimates ( I 2=87.3%, P <0.01). In additon, a significant positive association was estimated in American ( SMD =0.27, 95% CI =0.16-0.39) and Europe ( SMD =3.76, 95 CI =2.77-4.74). The association between BPA and obesity was not changed in each individual (sensitivity analysis by leaving one out approach). The funnel plots did not reveal severe asymmetry, and both Egger and Begg tests were non-significant ( P >0.05); therefore, publication bias was assessed as “undetected”.@*Conclusion@#The finding from our systematic review and Meta-analysis suggest that children and adolescents exposure to BPA may result in obesity.