Expressions of CDK5 and p35/p25 in the blood of patients with vascular cognitive impairment / 西安交通大学学报(医学版)

ABSTRACT

Objective: To investigate the expressions and possible roles of cyclin dependent kinase 5 (CDK5), p35 and P25 in the blood of patients with vascular cognitive impairment (VCI). Methods: Totally 91 cases of VCI were recruited as the study group, including 49 cases of non-dementia vascular cognitive impairment (VCIND) and 42 cases of vascular dementia (VAD), and 30 cases of cerebral apoplexy cognitive function (NC) and healthy control (N) group, respectively. RT-qPCR was used to detect the relative expression of CDK5 mRNA in the blood. Western blot method was used to detect the protein expressions of CDK5, p35 and p25 in each group. Results: The relative expression of CDK5 mRNA and the expression levels of CDK5, p35 and p25 protein in the four groups VAD>VCIND>NC>N respectively, with significant differences among the groups (P<0.05). Conclusion: CDK5, p35 and p25 may be involved in the occurrence of VCI, and their expression levels are positively correlated with VCI.