Inhibitory effects of tannins from leaves of Hippophae rhamnoids and their anti-inflammatory and anti-obesity effects / 中草药
Chinese Traditional and Herbal Drugs
; (24): 2809-2816, 2019.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-851047
Biblioteca responsável:
WPRO
ABSTRACT
Objective:
To study the anti-inflammatory and anti-obesity constituents from the leaves of Hippophae rhamnoids.Methods:
Several open-column chromatographic techniques and semi-preparative HPLC were used to separate and purify the compounds in H. rhamnoids. The structures of isolated compounds were elucidated by the spectroscopic analysis. Their inhibitory effects on nitric oxide production in RAW264.7 cells, and triglyceride accumulation in 3T3-L1 cells were examined.Results:
Eighteen tannins and other compounds were isolated and identified as 1,2,6-tri-O-galloyl-β-D-glucopyranose (1), 1,3,6-tri-O-galloyl-β-D- glucopyranose (2), 1,4,6-tri-O-galloyl-β-D-glucopyranose (3), 1,3,4,6-tetra-O-galloyl-β-D-glucopyranose (4), 1,2,3,6-tetra-O-galloyl- β-D-glucopyranose (5), 1,2,3,4,6-penta-O-galloyl-β-D-glucopyranose (6), 1-O-galloyl-4,6-(S)-HHDP-β-D-glucopyranose (7), 1-O- galloyl-2,3-(S)-HHDP-β-D-glucopyranose (8), 1,3-di-O-galloyl-4,6-(S)-HHDP-β-D-glucopyranose (9), 1,6-di-O-galloyl-2,3-(S)- HHDP-β-D-glucopyranose (10), casuarictin (11), 1,2,3-tri-O-galloyl-4,6-(S)-HHDP-β-D-glucopyranose (12), 1,4,6-tri-O-galloyl-2,3-(S)- HHDP-β-D-glucopyranose (13), hippophaenin B (14), pedunculagin (15), casuarinin (16), ellagic acid (17), and pinitol (18).Conclusion:
Tannins from the leaves of H. rhamnoides showed anti-inflammatory and anti-obesity activities. Compounds 2, 3, 5, 6, 8, 10, 12, and 13 were isolated from this genus for the first time.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Traditional and Herbal Drugs
Ano de publicação:
2019
Tipo de documento:
Artigo