Research progress on active quercetin derivatives with antitumor effect / 中草药

ABSTRACT

Quercetin, as a natural product of flavonoids, has many pharmacological activities, and its excellent antitumor activity has been concerned by many scholars at home and abroad in recent years. However, quercetin is poorly water-soluble because of its special molecular structure, which affects its medicinal value in clinic. Therefore, the chemical modification of its structure to improve its bioavailability or antitumor activity has become a hot research topic. In this paper, recent advances in the study of quercetin derivatives with anticancer activity, such as quercetin ester derivatives, metal complexes, ether derivatives, and other derivatives are reviewed, which provides scientific basis for the future development of antitumor drugs from quercetin.