Role of Nrf2 signaling pathway in liver regeneration and research progress of related drugs / 中国药理学通报

ABSTRACT

Liver can regenerate after chemical damage or partial hepatectomy. Liver regeneration is a complex process involving a variety of cytokines und multiple signal pathways. NK2 is a sensitive transcription factor of oxidation-reduction, which plays a regulatory role in cell defense, oxidation-reduction balance, inflammation and intermediate metabolism. It is closely related to cell proliferation. Some reports ha\e proved that liver regeneration is delayed after partial hepalectomy. Furthermore, ihis phenomenon is observed in the mice with absence of Nrf2. There fore. NrQ signaling pathway is involved in the process of liver regeneration. This article reviews the role of Nri2 signaling pathway in the process of liver regeneration according to the existing research results. We have also summarized the drugs that may affect liver regeneration or hepatocyte proliferation, hoping to find more drugs for liver diseases and provide ideas for the mechanism of the drugs.