Mixed terpenoids from an endophyte Alternaria sp. Ly81 cultivated on Maytenus hookeri / 中国药学杂志
Chinese Pharmaceutical Journal
; (24): 1823-1826, 2014.
Article
em Zh
| WPRIM
| ID: wpr-860151
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE:
To study the secondary metabolites and their cytotoxic activities of an endophytic fungus Alternaria sp. Ly81 cultivated on Maytenus hookeri.METHODS:
Column chromatography by RP-18, Sephadex LH - 20 and silica gel was used to isolate and purify the chemical constituents, and their structures were identified by spectroscopic analysis. Cytotoxic activities were evaluated by MTT method.RESULTS:
Nine compounds were isolated and identified as tricycloalternarene 2a(1), tricycloalternarene 1a(2), tricycloalternarene 1b(3), tricycloalternarene 2b(4), tricycloalternarene 3b(5), tricycloalternarene 4b(6), tricycloalternarene 5b(7), tricycloalternarene-H(8) and tricycloalternarene F(9).CONCLUSION:
Compounds 1 - 9 were isolated from the Alternaria sp. Ly81 for the first time. The absolute configuration of compound 1 is elucidated by Mosher's method. Compound 3 shows strong inhibitory activity against Lewis lung carcinoma cells 3LL.
Texto completo:
1
Base de dados:
WPRIM
Idioma:
Zh
Revista:
Chinese Pharmaceutical Journal
Ano de publicação:
2014
Tipo de documento:
Article