Expression of CDK5 and its correlation with peripheral inflammation-related cells and prognosis in colon cancer patients / 中华普通外科杂志
Chinese Journal of General Surgery
; (12): 774-778, 2021.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-911615
Biblioteca responsável:
WPRO
ABSTRACT
Objective:
To identify the clinical significance of CDK5 in colon cancer tissues.Methods:
Two hundred colon cancer tissues were tested for CDK5 expression by immunohistochemistry on tissue microarrays. The correlation between CDK5 expression and clinicopathological features, prognosis and peripheral inflammation-related cells was analyzed.Results:
CDK5 was low expressed in 100 cases (50.0%), and high in another 100 cases (50.0%). Longer time to tumor progression ( P=0.026) and overall survival ( P=0.035) were observed in patients with high CDK5 expression. By multivariate analysis , the expression of CDK5 was an independent risk factor for poor prognosis ( HR=0.45,95% CI 0.21-0.99, P=0.049). The expression of CDK5 was not related to the counts of white blood cells and neutrophils ( P>0.05). Prognosis of patients with a positive lymph node ratio less than 0.15 was significantly better than that of patients with a higher lymph node ratio ( P<0.001).Conclusions:
Patients with low CDK5 expression have poor prognosis, and CDK5 expression is not related to the counts of peripheral white blood cells and neutrophils.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Estudo prognóstico
Idioma:
Chinês
Revista:
Chinese Journal of General Surgery
Ano de publicação:
2021
Tipo de documento:
Artigo