Analysis of Once-Daily Thoracic Radiotherapy Dose According to the Underlying Lung Disease in Patients with Limited-Stage Small Cell Lung Cancer Undergoing Concurrent Chemoradiotherapy / Journal of the Korean Cancer Association, 대한암학회지
Cancer Research and Treatment
; : 73-82, 2023.
Article
em En
| WPRIM
| ID: wpr-966493
Biblioteca responsável:
WPRO
ABSTRACT
Purpose@#In the treatment of concurrent chemoradiotherapy (CCRT) in limited-stage small cell lung cancer, the optimal once-daily radiotherapy (RT) dose/fractionation remain unclear although it is the most frequently used. Therefore, this study aimed to compare the treatment outcomes and toxicities of modest dose RT (≤ 54 Gy) with those of standard dose RT (> 54 Gy) and investigate the benefit of the high dose based on patient factors. @*Materials and Methods@#Since 2004, our institution has gradually increased the thoracic RT dose. Among the 225 patients who underwent CCRT, 84 patients (37.3%) received > 54 Gy. Because the patients treated with RT > 54 Gy were not randomly assigned, propensity score matching (PSM) was performed. @*Results@#The proportion of patients treated with > 54 Gy increased over time (p=0.014). Multivariate analysis revealed that the overall tumor stage and dose > 54 Gy (hazard ratio, 0.65; p=0.029) were independent prognostic factors for overall survival (OS). PSM confirmed that thoracic RT doses of > 54 Gy showed significantly improved progression-free survival (3-year, 42.7% vs. 24.0%; p 54 Gy was not observed but considerable rates of severe pulmonary toxicities were observed (p=0.001). @*Conclusion@#Our analysis supports that the 60 Gy RT dose should be considered in the once-daily regimen of CCRT for limited-stage small cell lung cancer without underlying lung disease, but RT dose > 54 Gy did not seem to benefit for patients with chronic obstructive pulmonary disease or interstitial lung disease. Further study is needed to validate these results.
Texto completo:
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Base de dados:
WPRIM
Idioma:
En
Revista:
Cancer Research and Treatment
Ano de publicação:
2023
Tipo de documento:
Article
País de publicação:
COREA DEL SUR
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COREIA DO SUL
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KR
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SOUTH KOREA