Regulation and influence of mitochondria on macrophages during hepatitis B virus infection / 中华肝脏病杂志
Chinese Journal of Hepatology
; (12): 649-652, 2023.
Article
em Zh
| WPRIM
| ID: wpr-986186
Biblioteca responsável:
WPRO
ABSTRACT
Hepatitis B virus (HBV) infection is an important public health concern, as approximately 3.5% of the world's population is currently chronically infected. Chronic HBV infection is the primary cause of cirrhosis, hepatocellular carcinoma, and deaths related to liver disease globally. Studies have found that in HBV infection, viruses can directly or indirectly regulate mitochondrial energy metabolism, oxidative stress, respiratory chain metabolites, and autophagy, thereby altering macrophage activation status, differentiation types, and related cytokine secretion type and quantity regulations. Therefore, mitochondria have become an important signal source for macrophages to participate in the body's immune system during HBV infection, providing a basis for mitochondria to be considered as a potential therapeutic target for chronic hepatitis B.
Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Vírus da Hepatite B
/
Hepatite B Crônica
/
Hepatite B
/
Neoplasias Hepáticas
/
Macrófagos
/
Mitocôndrias
Limite:
Humans
Idioma:
Zh
Revista:
Chinese Journal of Hepatology
Ano de publicação:
2023
Tipo de documento:
Article
País de publicação:
CHINA
/
CN
/
REPUBLIC OF CHINA