Aspectos clínicos e procedência de pacientes sépticos atendidos em um hospital universitário / Aspectos clínicos y procedencia de pacientes sépticos atendidos en un hospital universitario / Clinical aspects and the origin of sepsis patients treated at a university hospital

Resumo Objetivo: Caracterizar os aspectos clínicos, gravidade e mortalidade de pacientes com sepse atendidos em setor de urgência e emergência de um hospital terciário, relacionando-os aos serviços de saúde de origem, onde foi feito o atendimento inicial. Métodos: Trata-se de um estudo transversal, quantitativo, realizado com pacientes sépticos atendidos em setor de urgência e emergência de um hospital universitário terciário. Resultados: Dos 225 pacientes elegíveis, 115 (51,1%) foram admitidos com sepse, e destes, 63,5% foram encaminhados de outros serviços. Entre os pacientes procedentes de outros serviços o desenvolvimento do choque séptico e necessidade de ventilação mecânica foi significativamente mais frequente. Os pacientes admitidos no hospital do estudo por sepse tiveram maior aderência ao pacote de 3 horas da Surviving Sepsis Campaining-2016. Não houve diferença entre a mortalidade dos admitidos por sepse ou aqueles que desenvolveram sepse no hospital do estudo, entretanto, evoluíram a óbito 60,4% dos pacientes, destes, 63,2% procedentes de outros serviços. Conclusão: Mais da metade dos pacientes admitidos por sepse provém de outros serviços de saúde. Estes apresentaram maior grau de gravidade e requereram mais intervenções terapêuticas. Entretanto, não houve diferença nas taxas de mortalidade.

Resumen Objetivo: Caracterizar los aspectos clínicos, gravedad y mortalidad de pacientes con sepsis atendidos en sector de urgencia y emergencia de un hospital terciario, relacionándolos con los servicios de salud de origen, donde se realizó la atención inicial. Métodos: Se trata de un estudio transversal, cuantitativo, realizado con pacientes sépticos atendidos en sector de urgencia y emergencia de un hospital universitario terciario. Resultados: De los 225 pacientes elegibles, 115 (51,1%) fueron admitidos con sepsis, y de éstos, el 63,5% fueron encaminados de otros servicios. Entre los pacientes procedentes de otros servicios el desarrollo del shock séptico y la necesidad de ventilación mecánica fue significativamente más frecuente. Los pacientes admitidos en el hospital del estudio por sepsis tuvieron mayor adherencia al paquete de 3 horas de la Surviving Sepsis Campaining-2016. No hubo diferencia entre la mortalidad de los admitidos por sepsis o aquellos que desarrollaron sepsis en el hospital del estudio, sin embargo, evolucionaron a muerte el 60,4% de los pacientes, de éstos, el 63,2% procedentes de otros servicios. Conclusión: Más de la mitad de los pacientes admitidos por sepsis provienen de otros servicios de salud. Estos presentaron mayor grado de gravedad y requirieron más intervenciones terapéuticas. Sin embargo, no hubo diferencia en las tasas de mortalidad.

Abstract Objective: To characterize the clinical aspects, severity and mortality of sepsis patients treated in the urgency and emergency departments of a tertiary hospital, relating them to the health services of origin, where initial care was performed. Methods: Cross-sectional, quantitative study with sepsis patients, treated in the urgency and emergency departments of a tertiary university hospital. Results: Of the 225 eligible patients, 115 (51.1%) were hospitalized with sepsis; of these, 63.5% were referred from other services. Among patients from other services, the development of septic shock and the need for mechanical ventilation was significantly more frequent. Patients admitted to the sepsis study hospital had greater adherence to the 3-hour package of the Surviving Sepsis Campaining-2016. There was no difference between the mortality of those admitted for having sepsis and those who developed sepsis in the study hospital. However, 60.4% of the patients died, 63.2% of whom came from other services. Conclusion: More than half of the patients hospitalized with sepsis come from other health services. they presented a greater degree of severity and required more therapeutic interventions. However, there was no difference in mortality rates.

Prevalence and factors associated with syphilis in a Reference Center

Abstract INTRODUCTION: The implementation of the rapid test (RT) for syphilis increases access of vulnerable populations to early diagnosis and treatment, impacting the outcomes of infection. We aimed to assess the prevalence of and factors associated with syphilis in a Center for Testing and Counseling (CTC). METHODS: We conducted a cross-sectional study at a Reference Center for sexually transmitted disease (STD) and acquired immune deficiency syndrome in Londrina, Northern Paraná State, Southern Brazil. Data regarding the 5,509 individuals who underwent RT from June 2012 to December 2014 were collected from patient records and the CTC Information System and served as the basis to check associations of syphilis cases (346) and cases without syphilis (5,163). Nine patients’ records were not found. OpenEpi was used to perform a prevalence analysis and determine odds ratios to assess the associations between sociodemographic and behavioral variables (independent variables) and cases of syphilis (dependent variable). An alpha value <0.05 was considered statistically significant. RESULTS: The prevalence of syphilis was 6.3%; higher in males (7.5%) than in females (4.3%, p <0.001). Syphilis was associated with an age of 25-34 years, little education, and single marital status. The main associated behavioral factors were men who have sex with men, drug users, STD patients, and those presenting with an STD in the last year. The use of alcohol, marijuana, cocaine, and crack was significantly associated with syphilis. CONCLUSIONS: Strategies for prevention and control of syphilis should be intensified, especially in populations identified as most vulnerable.