The brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism affects memory performance in older adults

Objective: Memory impairment is an important contributor to the reduction in quality of life experienced by older adults, and genetic risk factors seem to contribute to variance in age-related cognitive decline. Brain-derived neurotrophic factor (BDNF) is an important nerve growth factor linked with development and neural plasticity. The Val66Met polymorphism in the BDNF gene has been associated with impaired episodic memory in adults, but whether this functional variant plays a role in cognitive aging remains unclear. The purpose of this study was to investigate the effects of the BDNF Val66Met polymorphism on memory performance in a sample of elderly adults. Methods: Eighty-seven subjects aged > 55 years were recruited using a community-based convenience sampling strategy in Porto Alegre, Brazil. The logical memory subset of the Wechsler Memory Scale-Revised was used to assess immediate verbal recall (IVR), delayed verbal recall (DVR), and memory retention rate. Results: BDNF Met allele carriers had lower DVR scores (p = 0.004) and a decline in memory retention (p = 0.017) when compared to Val/Val homozygotes. However, we found no significant differences in IVR between the two groups (p = 0.088). Conclusion: These results support the hypothesis of the BDNF Val66Met polymorphism as a risk factor associated with cognitive impairment, corroborating previous findings in young and older adults.

Influence of family socioeconomic status on IQ, language, memory and executive functions of Brazilian children

Abstract The aim of this study was to assess the effect of family socioeconomic status (SES) and parental education on non-verbal IQ and on the processing of oral and written language, working memory, verbal memory and executive functions in children from different age ranges. A total of 419 Brazilian children aged 6­12 years old, attending public and private schools from Porto Alegre, RS participated in the study. Structural equation analyzes revealed that in the general model (for all ages), the SES contributed to cognitive performance ­ IQ, verbal memory, working memory, oral and written language and executive functions (28, 19, 36, 28 and 25 %, respectively). SES had stronger effects on younger children (up to nine years old), in most cognitive tasks examined. Probably, after this age, a combination of factors such as schooling, living in other social environments, among others, may mitigate the effects of family socioeconomic status.

Exposure to maltreatment and urban violence in children working on the streets in São Paulo, Brazil: factors associated with street work

Objective: To quantitatively study the exposure to childhood maltreatment and urban violence in children from families with at least one child working on the streets and to investigate the relationship between these factors and street work. Methods: Families who participated in a nongovernmental organization (NGO) program to eliminate child labor were included. Data concerning sociodemographic characteristics, punishment methods used in the family environment against the children, five types of abuse and neglect perpetrated by the caregivers, urban violence exposure and family functioning were collected. Results: The sample included 126 children who were working on the streets and 65 siblings who were not working on the streets. Caregivers reported high levels of severe physical punishment. The children reported high levels of abuse and neglect, and high levels of urban violence exposure. The families showed a predominance of dysfunctional and unsatisfactory relationships. A multiple logistic regression model showed that age older than 12 years and severe physical punishment at home were associated with street work. Conclusion: Interventions to decrease the risk of child street work should be family-focused and should aim to reduce violence in the family environment. .

Variáveis psicossociais e desempenho em leitura de crianças de baixo nível socioeconômico / Psychosocial Variables and Reading Performance of Children with Low Socioeconomic Status

Este estudo longitudinal investigou a contribuição de fatores psicossociais para o desempenho em leitura de crianças. Participaram 59 mães e seus filhos aos 4 meses, 2, 5-6 e 9-11 anos. Correlacionou-se o desempenho em leitura das crianças a variáveis psicossociais. Encontrou-se correlações negativas entre morbidade psiquiátrica materna na primeira infância e leitura de palavras irregulares e entre o número de familiares que residiam com a criança aos 2 e 5-6 anos e o desempenho na leitura de palavras. A renda familiar aos 2 anos correlacionou-se positivamente com compreensão textual. Entretanto, apenas o número de familiares que residiam com a criança foi preditor do desempenho em leitura de palavras. Conclui-se que o desempenho em leitura relaciona-se a fatores psicossociais.

This longitudinal study investigated the impact of psychosocial factors on reading performance of children with low socioeconomic status. Fifty nine mothers and their children at 4 months, 2, 5-6 and 9-11 years of age participated. The children's reading performance was correlated with psychosocial variables. Negative correlations were found between maternal psychiatric morbidity in early childhood and reading of irregular words, and between the number of family members living with the child at 2 and 5-6 years and word reading performance. Family income at 2 years correlated positively with reading comprehension. However, only the number of family members who lived with the child was a predictor of reading performance. The results indicate that reading performance is related to psychosocial factors.

Artrite reumatóide e depressão / Rheumatoid arthritis and depression

A depressão é uma doença freqüentemente subdiagnosticada e dificilmente bem manejada em pacientes com artrite reumatóide(AR). É possível verificar que alterações psicopatológicas podem ser decorrentes da AR, ou, pelo menos, de uma estado de dor crônica. Quanto à etiologia, não há base científica consistente que permita afirmar que distúrbios psiquiátricos participem da fisiopatologia dessa doença e vice-versa, sendo necessária a realização de estudos mais criteriosos nesse sentido. Todavia, as repercussões que a depressão pode provocar na qualidade de vida e prognóstico dos pacientes com AR já justificam por si o dever dos clínicos em atentar para o diagnóstico dessa co-morbidade e para o adequado manejo dessa situação. Nesta revisão bibliográfica são abordados fatores etiológicos, diagnóstico e o manejo de pacientes portadores de Ar e transtornos do humor