Sociodemographic and clinical profile of patients with occupational contact dermatitis seen at a work-related dermatology service, 2000 - 2014

Abstract: BACKGROUND: Occupational dermatoses are common, especially contact dermatitis. Epidemiological studies on these dermatoses are scarce in Brazil and they are necessary as part of the public policy to protect workers' health. OBJECTIVES: To identify sociodemographic and clinical profile of patients with occupational contact dermatitis seen between 2000 and 2014 at an occupational dermatology service. METHODS: It is a cross-sectional and retrospective study, based on information obtained from the service's database. RESULTS: Of 560 patients with conclusive patch test, 289 (46.9%) presented occupational dermatoses and 213 occupational contact dermatitis with predominance of the allergic type in relation to the irritative type (149:64 respectively). The odds of occupational dermatoses were higher among men and lower among patients aged 50 years or older and with higher level of education. Regarding the possibility of presenting occupational allergic contact dermatitis, only the gender variable was statistically significant. The professions most seen were cleaners, construction workers, painters, mechanics/metallurgists and cooks. The commonest allergens were nickel sulfate, potassium dichromate, cobalt chloride, carba-mix and formaldehyde. STUDY LIMITATIONS: The main limitations of this study are the fact that it was carried out in a tertiary service of occupational dermatoses and the lack of access to some allergens outside the patch test baseline series. CONCLUSIONS: It was possible to identify the sociodemographic and clinical profile of patients with suspected occupational contact dermatitis seen at the Service, beyond the professional groups and allergens related to a high risk of occupational contact dermatitis in this population.

Evaluation of the profile of inflammatory cytokines, through immunohistochemistry, in the skin of patients with allergic contact dermatitis to nickel in the acute and chronic phases

Abstract: Background: Allergic contact dermatitis to ion nickel (Ni+2) is an inflammatory dermatosis, common in industrialized countries. It involves the activation of nickel-specific T-cells, followed by proliferation and induction of a mixed profile of both proinflammatory and regulatory cytokines, suggesting that several T-cell subtypes (helper - Th and cytotoxic - Tc) are involved. A broader understanding of the cytokine profile may lead to new therapeutic approaches. Objectives: This study aimed to analyze the cytokines TNF-α, INF-γ, IL-2, IL-4, IL-10, IL-13, IL-17 and IL-23 using the immunohistochemistry technique in order to try to identify their prevalence in chronic and acute eczema of patients with allergic contact dermatitis to Ni+2. Methods: We performed an immunohistochemical study for eight cytokines in 20 patients with Ni+2 allergic contact dermatitis, biopsied at the site of chronic eczema, triggered by the patient's daily contact with Ni+2, and at the site of acute eczema caused by nickel sulfate, 48 hours after applying the contact test. Results: The stained samples showed positive results for the eight cytokines studied. TNF-α, IFN-γ, IL-4, IL-13 and IL-17 had a higher prevalence in chronic eczema, IL-2 and IL-23 in acute eczema, and IL-10 presented a similar prevalence in both acute and chronic eczema. However, these prevalences were statistically significant only for IL-4 and IL-13. Study Limitations: Small sample size. Conclusions: In chronic and acute eczema, we observed the presence of a mixed cytokine profile of the T cell subtypes (Th/Tc), suggesting that the responses are expressed at the same time.

Dermatite alérgica à picada de Culicoides em muar: relato de caso / Allergic dermatitis due to bite of Culicoides in muar: case report

A dermatite alérgica à picada de ectoparasitos é uma enfermidade alergoparasitária bastante comum entre animais domésticos, sendo relatada principalmente em pequenos ruminantes e em animais de companhia. Contudo, a doença é pouco diagnosticada na clínica de equídeos devido a similaridades nosológicas com outras dermatopatias. Objetivou-se, com este relato de caso, descrever a síndrome clínica, o plano diagnóstico e a conduta terapêutica de um muar acometido por essa enfermidade. Atendeu-se, no Hospital Veterinário da Universidade Federal Rural do Pernambuco, uma mula de oito anos de idade, que apresentava lesões cutâneas pápulo-crostosas e pruriginosas com evolução clínica de dois anos. Em três situações anteriores, a doença havia sido tratada como dermatite fúngica por outros médicos veterinários. Para o diagnóstico, foram solicitados exame citopatológico e parasitológico de pele, cultivo bacteriológico e fúngico, análise histopatológica e hemograma. Os exames demonstraram uma dermatite superficial perivascular eosinofílica crônica, sendo indicada a terapia tópica com dimetilsufóxido, sulfadiazina, ureia e vitamina A. O protocolo terapêutico mostrou-se satisfatório, permitindo completa remissão do quadro clínico. Este trabalho relatou achados clínicos e patológicos da dermatite alérgica à picada de Culicoides spp. em muar, além de alertar sobre a importância de exames complementares para a realização do diagnóstico diferencial e para o direcionamento terapêutico adequado.(AU)

Allergic dermatitis to ectoparasite bites is a common parasitic disease among domestic animals, being reported mainly in small ruminants and companion animals. However, the disease is poorly diagnosed in equine clinics due to nosological similarities with other skin diseases. The aim of this case report was to describe the clinical syndrome, the diagnostic plan and the therapeutic management of a mule affected by this disease. An 8-year-old mule was observed at Universidade Federal Rural de Pernambuco, presenting papular-crusted and pruritic cutaneous lesions with clinical evolution of two years. In three previous situations, the disease had been treated as fungal dermatitis by other veterinarians. For the diagnosis, cytopathological and parasitological examination of the skin, bacteriological and fungal culture, histopathological analysis and blood count were performed. The exams showed a chronic eosinophilic perivascular superficial dermatitis. A topical therapy with dimethyl sulfoxide, sulfadiazine, urea, and vitamin A was indicated. The therapeutic protocol was satisfactory, allowing complete remission of the clinical condition. This work reported clinical and pathological findings of allergic dermatitis to the bites of Culicoides spp. in muar, in addition to alerting about the importance of complementary examinations for the accomplishment of the differential diagnosis and adequate therapeutic orientation.(AU)

Valoración médico legal de la dermatitis alérgica de contacto en el ámbito laboral / Legal medical assessment of allergic contact dermatitis in the workplace

Resumen.La primera barrera con el medio ambiente que protege contra sustancias nocivas y organismos es la piel. Las actividades humanas son sumamente diversas y muchas de los trabajos pueden actuar en detrimento de esta barrera natural provocando enfermedades dermatológicas asociadas con la dinámica laboral. El 90% de todas las dermopatías laborales son dermatitis de contacto, la cual puede ser irritativa o alérgica. En la mayoría de los casos se trata de un eczema en zonas expuestas del cuerpo y con cierta frecuencia en las manos. El diagnóstico se basa en una historia clínica y examen físico detallados, conocimiento de las sustancias que permita diferenciar los irritantes de los alérgenos y una correcta interpretación de las pruebas de alergia. Este es conocimiento básico para peritar en el ámbito médico legal.

Abstract.The skin is the primary interface with external environment and performs quite efficiently as a barrier against noxious chemicals or living organisms. The range of human activities is extremely diversified and many occupations can lead to break down of the epidermal barrier, with subsequent development of work-related dermatoses.Occupational contact dermatitis accounts for 90% of all causes of work-related cutaneous disorders. It can be divided into irritant contact dermatitis, wich occurs in 80% of cases and allergic contact dermatitis. In most cases, both types will present as eczematous lesions on exposed parts of the body, notably the hands. Accurate diagnosis relies on meticulous history taking, thorough physical examination, careful distinguishing between irritants and allergens, and comprehensive patch testing to confirm or ruled out allergic sensitization. This is a basic review to issue a forensic professional judgement.

Incidence of allergic contact sensitization in central Chinese subjects with chronic urticaria

Abstract BACKGROUND: Chronic urticaria (CU) can be provoked by a wide variety of causes. Some studies suggest contact sensitization may play a role in the disease. OBJECTIVE: To investigate the incidence and distribution characteristics of allergic contact sensitization in central Chinese subjects with CU, and assess contact allergen avoidance measures in managing CU. METHODS: Patch tests were performed, following the recommended standard procedure, with 20 selected allergens, in line with the European baseline series. All subjects with positive results were prescribed appropriate avoidance measures for the sensitizing substances, while subjects with negative results served as the control group. CU severity was assessed daily from week1 to week4 and for each subject, applying the Urticaria Activity Score. RESULTS: 42.9% (233/543) of subjects with CU showed positive reactions to one or more contact allergen(s). Potassium dichromate, benzene mix and carba mix were more common in male patients, while nickel sulfate was more frequent in females. The positive rates for different allergens varied with age and occupation. The median (interquartile range) severity scores at week 1 were 20 (14-21) and 15 (14-27) for the allergen avoidance group and control group, respectively (P>0.05); and 12 (7-15) and 14 (12-17) at week 4 (P<0.001). CONCLUSION: The incidence of allergic contact sensitization in CU patients was high, and appropriate contact allergen avoidance measures benefitted CU management. Contact allergens may play a role in the pathogenic mechanism of CU and patch tests are an option for CU patients.

Frequência da dermatite de contato ocupacional em ambulatório de alergia dermatológica / Frequency of occupational contact dermatitis in an ambulatory of dermatologic allergy

FUNDAMENTOS: A dermatite de contato ocupacional (DCO) corresponde a 80 por cento dos casos de dermatoses relacionadas ao trabalho. OBJETIVOS: Determinar: a frequência de DCO em pacientes atendidos em ambulatório de alergia, não específico de dermatose ocupacional; o perfil dos pacientes de acordo com idade, sexo, cor, profissão, antecedentes atópicos, duração e localização da dermatose; os tipos de dermatite de contato; os principais alérgenos; e comparar as frequências dos principais sensibilizantes com os resultados obtidos em pacientes atendidos no mesmo período, sem DCO. MÉTODOS: Durante o período 2003-2006, 630 pacientes foram atendidos e submetidos à bateria padrão de testes de contato. Selecionaram-se aqueles com DCO. RESULTADOS: Sessenta e nove (10,9 por cento) pacientes apresentaram DCO. A média de idade foi de 44,5 anos. As mãos foram acometidas em 48 (70 por cento) casos. As profissões prevalentes foram do lar (27,39 por cento) e construção civil (23; 33,5 por cento). Dermatite alérgica de contato (DAC) ocorreu em 48 (70 por cento) casos, e dermatite irritativa de contato (DIC), em 21 (30 por cento). Os principais sensibilizantes foram o bicromato de potássio (28; 41 por cento), sulfato de níquel (16; 23 por cento) e carba-mix (16; 23 por cento). CONCLUSÕES: A DCO foi diagnosticada em 10,9 por cento dos pacientes, sendo mais comum na faixa etária produtiva da população. DAC esteve presente em 48 casos, provavelmente influenciada pelo longo tempo de evolução da dermatose. Os metais e os componentes da borracha foram os principais sensibilizantes.

BACKGROUND: Occupational contact dermatitis (OCD) corresponds to 80 percent of the cases of skin diseases related to work. OBJECTIVES: To determine: the frequency of OCD in an ambulatory of allergy not specific for occupational dermatosis; the profile of these patients according to age, gender, color, profession, atopic history, duration and localization of the dermatosis; the diagnosed types of contact dermatitis; the main allergens and to compare the frequency of the main antigens with the results obtained from patients examined in the same period of time, without DCO. METHODS: During the three-year period from 2003 to 2006, 630 patients were examined and submitted to a battery of standardized contact patch tests and those who were diagnosed with OCD were selected. RESULTS: Sixty-nine out of the 630 patients were diagnosed with OCD. The average age was 44.5 years. Forty-eight patients (70 percentof the cases) presented the disease on the hands. The most prevalent activities of patients suffering from the disease were household tasks (39 percent) and building construction (33 percent). The allergic contact dermatitis (ACD) occurred in 48 cases which represent 70 percent of the total number of cases and irritant contact dermatitis in 21 cases corresponding to 30 percent of the total number of cases. The main allergens were potassium dichromate 28 (41 percent), nickel sulfate 16 (23 percent) and carba-mix 16 (23 percent). CONCLUSION: OCD was present in 10.9 percent of the patients. Concerning age the group in which the disease was more commonly found corresponded to the most productive group of the population. ACD corresponded to 48 cases, probably influenced by the long period of evolution of the dermatosis. Metal and rubber chemicals were the commonest allergens.

Un nuevo caso de sensibilización a reveladores de fotografía / A new case of sensitization to photo developers

Las dermatosis ocupacionales en trabajadores de fotografía son poco frecuentes en la actualidad. Los alergenos habituales son los reveladores de color CD-2, CD-3 y CD-4. Dichos productos pueden producir erupciones liquenoides y eczematosas. El caso que presentamos es el de un paciente varón de 35 años, trabajador de una empresa de revelados de fotografía desde hacía dos años. En el momento de la consulta presentaba lesiones eczematosas que afectaban mano derecha y ambos miembros superiores con intenso prurito. Se realizaron pruebas epicutáneas, con batería estándar del Grupo Español Internacional de Dermatitis de Contacto (GEIDC) y específica para fotografía, observándose resultados muy positivos para los reveladores de color CD-2, CD-3, CD-4 y TSS (4-amino-N, N-dietilalinina sulfato), así como moderado para hidroxilamonio. El tratamiento consistió en corticoides por vía oral y tópica, así como el cese de la actividad laboral relacionada con el contacto con dichas sustancias, lo que permitió la resolución completa de las lesiones cutáneas sin recidiva.

Occupational dermatitis in photography workers are quite rare nowadays. Common allergens are colour developers CD-2, CD-3 and CD-4. These products can cause lichenoid and eczematous eruptions. We present the case of a 35 year old male patient, who had been working in a photography development company for two years. At the time of the consult the patient presented eczemaous lesions involving the right hand and both arms with intense itching. Epicutaneous patch tests were performed with standard battery from the Spanish Group International Contact Dermatitis (GEIDC) and specifi c battery for photography, showing intense positive results for colour developers CD-2, CD-3, CD-4 and TSS (4-amino-N, N-dietilalinina sulfate), as well as moderate positive result to hydroxyl ammonia. Treatment consisted of oral and topic corticotherapy and the cessation of any work related to the contact with these substances, which allowed complete resolution of skin lesions without recurrence.

Reação adversa ao látex: relato de caso / Adverse reaction to latex: a case report

Os autores relatam caso de alergia a látex em trabalhador da saúde. Reações adversas ao látex podem se apresentar sob formas localizadas (dermatite alérgica e irritativa, ambas por contato) e sistêmica (alergia ao látex). O diagnóstico de uma das formas, quando relacionado ao trabalho, é perverso, tendo em vista que materiais e equipamentos que contêm látex como componente principal são utilizados de forma disseminada e em quantidade imensurável, portanto, estão presentes em postos de trabalho de todas as atividades, principalmente as relacionadas com o cuidado à saúde. No caso de luvas usadas em ambiente médico-hospitalar, apenas nos Estados Unidos estima-se que sejam consumidos acima de 7 bilhões de pares por ano. Além do contato, luvas também propiciam a disseminação de proteína do látex no ambiente, por meio de aerodispersóis, o que favorece a inalação de partículas. O artigo discute, em primeiro lugar, a definição diagnóstica de acordo com as apresentações possíveis. A seguir, discute as conseqüências que implicam principalmente a retirada do trabalhador de seu ambiente de trabalho e a dificuldade de reinseri-lo em outra atividade, justamente por se tratar de mão-de-obra especializada em atividades específicas.

The authors relate case of a female health care worker, who developed latex allergy.Adverse reaction to latex present under three types: irritant contact dermatitis, allergic contact dermatitis and immediate-type hypersensitivity (latex allergy). If work-related,diagnosing one of them is troublesome, because there is a great variety of equipment containing latex that are present in many work posts, where several activities are developed, mainly that related to health care. In the United States, it is stimated that about 7 billion gloves pairs are used per year. Besides contact, gloves propritiate latex protein dissemination in the environment, by forming powder, which contributes to inhalation of particles. The authors discuss, at first, the diagnosis definition, according to the possible presentation. After, they discuss the consequences that imply in removing the worker from his job and difficulty of to allocate him on other activity, just because he is a specialized worker.

Caracterização da hipersensibilidade a luvas de látex em profissionais da odontologia / Rubber latex gloves hypersensitivities in dental workers

As reações alérgicas ao látex vêm aumentando em profissionais da saúde e se manifestam como um incômodo local ou sintomatologia sistêmica. Para conhecer a freqüência das manifestações alérgicas nos usuários de luvas de látex foi realizada busca entre os profissionais da odontologia via aplicação de questionários. Foram aplicados 450 questionários e, dentre os respondedores (140), 19% relataram manifestar reações locais ao contato com as luvas de látex e 5% reações sistêmicas a outros produtos de látex. Cerca de 2,5% declararam dermatite de contato e reações sistêmicas (anafiláticas), 1,5% apenas dermatite de contato e 1% sintomas de anafilaxia ao uso das luvas. Vinte por cento dos profissionais atenderam pacientes com alergia ao látex e 29% declararam questionar, durante a anamnese, a respeito de alergia ao látex. As reações alérgicas a luvas de látex foram freqüentes e é objeto de preocupação entre os profissionais da odontologia.

Allergic reactions to natural rubber latex have increased in dental practice affecting both the professional and the patients. Allergic reactions may range from skin disease to asthma and anaphylaxis. This study aimed at determining the incidence of latex gloves allergy among dental care workers. 450 allergy questionnaires were used to collect information on latex gloves reactions and 140 dental works answered them. Latex gloves reaction occurred in 19% of them and 5% reported allergic reactions to other latex products. 2.5% reported symptoms suggesting contact dermatitis and anaphylaxis hypersensitivities, 1.5% contact dermatitis, and 1% reported anaphylaxis symptoms when wearing them. 20% of them had patients who presented symptoms suggestive of anaphylaxis hypersensitivity to rubber gloves latex. Our study confirms that rubber latex gloves reactions are frequent among dental care workers, and dentists must be aware of the latex allergy in dental practice.

Prevalencia y factores de riesgo de sensibilización al látex en personal del Hospital del Trabajador Santiago / Prevalence and risk factors of latex hypersensitivity in workers hospital personnel in Santiago

Los trabajadores de la salud (TS) tienen riesgo de desarrollar alergia al látex, lo que está respaldado por múltiples publicaciones. OBJETIVOS: Establecer prevalencia de sensibilización y alergia a látex en TS del Hospital del Trabajador Santiago (HTS) y determinar factores de riesgo asociados. MATERIALES Y MÉTODOS: Se estudiaron 157 TS con encuesta sobre atopia, tiempo y Los trabajadores de la salud (TS) tienen riesgo de desarrollar alergia al látex, lo que está respaldado por múltiples publicaciones. OBJETIVOS: Establecer prevalencia de sensibilización y alergia a látex en TS del Hospital del Trabajador Santiago (HTS) y determinar factores de riesgo asociados. MATERIALES Y MÉTODOS: Se estudiaron 157 TS con encuesta sobre atopia, tiempo y síntomas con exposición a látex. Se efectuaron prick test con aeroalergenos, látex y frutas (Leti, España), látex amoniacado, prick in prick con guantes de látex y test de parche con látex y aditivos (Trolab, Alemania). RESULTADOS: La sensibilización a látex fue de 13,4por ciento (n=21). Hubo diferencia significativa entre sensibilizados y no sensibilizados en: presencia de atopia (p<0,001), sensibilización a frutas (p<0,001) y presencia de urticaria de contacto (p<0,001). Tres TS de los 19 examinados presentaron test de parche positivo. CONCLUSIONES: La prevalencia de sensibilización a látex es menor a la encontrada en otro estudio nacional realizado por nuestro grupo. La atopia y la sensibilización a frutas tropicales parecen importantes factores para el desarrollo de alergia al látex en la población estudiada.

Exantemas febriles no infecciosos / Non infectious febrile rash

Exantema es una erupción de la piel con lesiones de distinto tipo, configuración y disposición. El diagnóstico diferencial para pacientes febriles con exantema es extenso. Las posibles causas son enfermedades infecciosas, drogas, enfermedades dermatológicas, inmunológicas y/o neoplásicas. Una historia detallada y un examen físico cuidadoso pueden ser esenciales para hacer un diagnóstico correcto. La historia debe incluir el sitio de comienzo, porcentaje y dirección de extensión, presencia o ausencia de prurito y relación temporal con la fiebre. En este artículo se revisarán diagnósticos no infecciosos de exantemas febriles

Características epidemiológicas en enfermedades laborales: descripción de 1469 casos / Epidemiologic characteristics in occupational diseases: description of 1469 cases

En el presente trabajo se describen 1469 casos diagnosticados como enfermedad del trabajo por la Unidad de Investigación, Docencia y Apoyo Clínico en Salud en el Trabajo, del Hospital General Regional No. 46 del Instituto Mexicano del Seguro Social en Guadalajara, Jalisco, en el lapso comprendido de enero de 1985 a octubre de 1993. Los diagnósticos más frecuentes fueron: trauma acústico crónico, dermatitis por contacto, neumoconiosis, bronquitis crónica y saturnismo, todos coinciden con lo reportado a nivel nacional. De las enfermedades de trabajo al momento del estudio 55 por ciento ameritaron evaluación por presentar secuelas irreversibles. Es prioritaria la implementación de programas de vigilancia epidemiológica en las empresas para prevenir los riesgos y disminuir las enfermedades de trabajo