The histology of prostate tissue following prostatic artery embolization for the treatment of benign prostatic hyperplasia

Objective Prostatic artery embolization (PAE) for the treatment of patients with symptomatic benign prostatic hyperplasia (BPH) is believed to be a safe procedure with a low risk of adverse side effects. Artery embolization is a viable treatment option in patients who are refractory to the classic noninvasive treatments. Knowledge of the histological characteristics of prostate tissue following the procedure is still limited. In this study, we describe the microscopic aspects of the prostate following PAE for BPH. Materials and Methods Two patients underwent transurethral resections of the prostate (TURP) after PAE. Embolizations were performed under local anesthesia with an initial pelvic angiography to evaluate the iliac vessels and the prostate arteries using a 2.8 French microcatheter. The prostate was embolized with 300-500µm Microspheres (Embosphere®), using complete blood stasis as the end point. The prostate tissues were analyzed histologically to characterize the effects of the embolization. Results The embolic material within the prostate tissue was easily identified as homogeneous, bright eosin-red spheroids filling the vessel lumens. Ischemic necrosis surrounded or not by chronic inflammatory reactions containing macrophages were considered as a result of the artery embolization. Also, some aspects related to the healing process were observed being fibrotic nodules surrounded by glands with squamous metaplasia of the epithelial lining the most important. In the remaining sections, due to the precocious surgical intervention, the classic findings of BPH were still present with the glandular and stromal hyperplasia associated with nonspecific chronic prostatitis. Conclusions This is the first description of prostate histology in BPH patients treated by PAE, a new procedure that is being used increasingly as a therapeutic intervention. The recognition of the changes caused by this new modality of treatment has ...

Patología prostática diagnosticada mediante biopsias en el servicio de anatomía patológica Dr Hans Doehnert del Hospital Central Universitario Antonio María Pineda (HCUAMP) de Barquisimeto durante el año 2000 / Prostatic pathology diagnosed by means of biopsies at the service of pathologycal anatomy Dr Hans Doehnert of the Hospital Central Universitario Antonio María Pineda

Se realizó una revisión de resultados de biopsia entr Enero y Diciembre del año 2000, tipo descriptiva longitudinal retrospectiva con la finalidad de analizar la patología prostática diagnosticada mediante biopsias en el Servicio de Anatomía Patológica Dr Hans Doehnert del Hospital Central Universitario "Antonio María Pineda" de Barquisimeto, para lo cual se seleccionaron 91 resultados con dichos diagnósticos. La patología más frecuente fue la Hiperplasia Prostática Benigna con Inflamación Crónica (39,6 por ciento), seguida de la Hiperplasia Prostática Benigna Aislada (31,8 por ciento), el Adenocarcinoma prostático fue diagnosticado en 9,9 por ciento de los casos. La Hiperplasia Prostática Benigna fue más frecuente entre 61 y 70 años (40 por ciento de los casos) y la prostatitis crónica entre 61 y 70 años (46 por ciento). En un 75,3 por ciento de los casos hubo correlación entre el diagnóstico preoperatorio y los hallazgos histológicos. El adenocarcinoma de próstata fue mas frecuente entre 71 y 75 años (37,5 por ciento), predominando los grados II y IV con un porcentaje de 37,5 por ciento cada uno. En la Neoplasia Intraepitelial Prostática el grado I se presentó con mayor porcentaje (63,6 por ciento)

Hiperplasia benigna da próstata: tratamento näo cirúrgico / Prostatic hypertrophy: non surgical treatment

Säo apresentadas e discutidas as alternativas näo cirúrgicas ao clássico e eficaz tratamento cirúrgico da Hiperplasia Benigna da Próstata, concluindo-se serem amplamente promissores os métodos alternativos de tratamento em estudo