Evaluation of the Frequency of Occupational Hazards Among a Group of Iranian General Dentists and its Prevention Criteria

ABSTRACT Objective To evaluate the frequency of occupational hazards and the criteria for their prevention among Iranian dentists. Material and Methods This cross-sectional study was conducted on 187 general dentists in Kerman. The data collection tool was a questionnaire including personal information (gender, age, marital status, condition and place and years of employment, and the average of weekly working hours) and a valid and reliable questionnaire of occupational hazards, including 24 questions about occupational hazards (6 domain) and nine questions about criteria for the prevention of the risks of dentistry. The t-test, chi-square, and linear regression were used. Results 92 (49.2%) were men. The mean and standard deviation of the score of occupational hazards was 27.04±16.21 out of 96, and the criteria of prevention were 22.00±7.28 out of 36. Regression analysis showed significant correlations between single statuses, years of occupational and type of employment, weekly work hours and occupational hazards, participation in occupational injury identification courses, and hepatitis vaccination. In addition, there were significant correlations between gender, age, weekly work hours, and preventive measures. Moreover, 3.2% of dentists were in a high-risk group and 26.2% were weak in preventive measures. Conclusion A total of 32.6% of dentists are at moderate risk of occupational hazards, and 10.7% meet the prevention criteria properly. It is recommended to hold training classes to identify occupational hazards and the criteria for their prevention among dentists.

Overview of the Effect of Complementary Medicine on Treating or Mitigating the Risk of Endometriosis / Visão geral do efeito da medicina complementar no tratamento ou mitigação do risco de endometriose

Abstract Objective Endometriosis is a hormone-dependent chronic inflammatory disease with symptoms such as pelvic pain, which affect the physical, emotional, and social health of women in reproductive age. The current overview article aims to explore the effect of complementary medicine on the treatment or in mitigating the risk of endometriosis. Methods This is an overview article done in Iran. Two separate researchers systematically searched 3 databases (Medline, Scopus, and Cochrane Central Register Trials) until September 2020. The methodological quality of each study was assessed using the assessment of multiple systematic reviews (AMSTAR) tool. Results The results of two reviews suggested that physical activity, tobacco smoking, diet, coffee and caffeine intake had no effect on mitigating the risk of endometriosis or improving its treatment, but acupuncture successfully reduced pain and related marker (serum CA-125) levels. Conclusion As endometriosis is an annoying disease with many complications and is hard to diagnose and treat, related studies in complementary medicine can help patients with endometriosis. Based on the relevant literature review, among the complementary medicine available for the treatment or to mitigate the risk of endometriosis, only acupuncture seems to alleviate the pain of endometriosis.

Resumo Objetivo A endometriose é uma doença inflamatória crônica hormono-dependente com sintomas como dores pélvicas, que afetam a saúde física, emocional e social de mulheres em idade reprodutiva. O presente artigo de visão geral tem como objetivo explorar o efeito da medicina complementar no tratamento ou na mitigação do risco de endometriose. Métodos Trata-se de um artigo de visão geral feito no Irã. Dois pesquisadores separados pesquisaram sistematicamente 3 bancos de dados (Medline, Scopus e Cochrane Central Register Trials) até setembro de 2020. A qualidade metodológica de cada estudo foi avaliada usando a ferramenta avaliação da qualidade dos relatos de revisão sistemática (AMSTAR, na sigla em inglês). Resultados Os resultados de duas revisões sugeriram que atividade física, tabagismo, dieta, consumo de café e cafeína não tiveram efeito na redução do risco de endometriose ou na melhoria do tratamento, mas a acupuntura reduziu com sucesso a dor e os níveis de marcadores relacionados (CA-125 sérico). Conclusão Como a endometriose é uma doença incômoda, com muitas complicações e de difícil diagnóstico e tratamento, estudos relacionados em medicina complementar podem ajudar pacientes com endometriose. Com base na revisão da literatura relevante, entre os medicamentos complementares disponíveis para o tratamento ou risco de endometriose, apenas a acupuntura parece aliviar a dor da endometriose.

Correlation Between Clinical and Histopathologic Diagnosis of Oral Potentially Malignant Disorder and Oral Squamous Cell Carcinoma

ABSTRACT Objective: To determine the frequency of oral potentially malignant disorders and Oral Squamous Cell Carcinoma (OSCC) and evaluate the consistency between their clinical and pathological features. Material and Methods: This retrospective study was conducted on records with a diagnosis of oral leukoplakia, oral erythroplakia, erythroleukoplakia, actinic cheilitis, lichen planus, and OSCC in the Pathology Department of Kerman dental school from September 1997 to September 2017. Data were analyzed in SPSS 21 at the significance level of ≤5%. Results: There were 378 cases of oral potentially malignant disorders and 70 cases of OSCC with a mean age of 46.82 ± 15.24 years. Buccal mucosa was the most frequent site, and lichen planus the most common lesion. Females were significantly older than males in leukoplakia and carcinoma in situ lesions. Clinical diagnosis and histopathology were consistent in 69.03% of cases. Conclusion: Clinical and histopathological diagnoses were consistent in 69.03% of records. The highest degree of clinical compliance with histopathology was observed in OSCC. Dentists should pay attention to oral potentially malignant disorders for early diagnosis to prevent their transformation to malignancy.

Quality of Life in Patients with Chronic Oral Mucosal Conditions: A Qualitative Research

ABSTRACT Objective: To use qualitative research methods to evaluate the experiences of patients with chronic oral diseases. Material and Methods: Purposive sampling was used to recruit patients from the Oral Medicine Unit of Kerman University Dental School. An experienced independent facilitator convened the focus groups and conducted individual interviews in a non-clinical setting. Focus groups were mixed regarding their gender, age, chronic oral mucosal condition, time since diagnosis, and severity. A total of 39 patients participated in the study, including patients with oral lichen planus, pemphigus, recurrent aphthous stomatitis and leukoplakia. Results: Analysis of the interviews revealed that patient views could be divided into the following themes: biopsychosocial issues, treatment limitations and side effects, unpredictability of the conditions and the potential for malignant transformation. Chronic oral mucosal conditions affected patients' daily lives in various areas, from physical health and functioning to concerns about their future. Conclusion: The oral medicine practitioner's role in treating patients with chronic oral mucosal diseases extended beyond active management and symptomatic relief to the management of all aspects of these conditions that affected their daily lives.

Quality of Life in Iranian Patients with Oral and Head and Neck Cancer

ABSTRACT Objective: To assess sociodemographic factors and cancer information on patients' quality of life with head and neck cancer. Material and Methods: This cross-sectional study was conducted on 69 patients with head and neck cancer who attended in one of the oncology centers in Mashhad, Iran, from September 2019 to December 2019. Data was collected through a questionnaire consisted of demographic information (gender, age, educational level, and job) and cancer information (type, location, treatment, clinical stage) and standard quality of life questionnaire (QLQ-H&N35). Data analyzed in SPSS22 software using T, ANOVA, Linear regression tests at 0.05 significant levels. Results: 49 participants (72.1%) were men. The mean age was 60.48 ± 13.74 years. Forty-nine participants (72.1%) had squamous cell carcinoma and 26 participants (38.2%) had a larynx tumor. Forty-six participants (67.6%) were in clinical stage 3, mainly with a problem and complain about hard food swallowing, xerostomia and speech. The mean score of QLQ-H&N35 was 42.06 ± 20.12 from 90. Quality of life in 47.1% of cases was moderate. There was no significant relationship between gender, job, educational level, type and location of cancer (p>0.05). There was a significant relationship between the patient's age, clinical stage, type of treatment, and quality of life (p<0.05). Conclusion: Quality of life in 47.1% was moderate. Clinical stage, age of patients and type of treatment statically and significantly affected the quality of life. Assessing quality of life in HNC patients can identify important side effects of treatment that affected quality of life and look for ways to improve QoL.

Tattooing among Iranian prisoners: results of the two national biobehavioral surveillance surveys in 2015-2016

Abstract Background: Tattooing is among identified risk factor for blood-borne diseases. Objective: This study aims to determine the prevalence of tattooing during lifetime and in prisons and its related factors among Iranian prisoners. Methods: This is a cross-sectional study. The required data was obtained from hepatitis B and C surveillance surveys in prisons in 2015-2016 that was collected through face-to-face interview. 12,800 prisoners were selected by multi-stage random sampling from 55 prisons of 19 provinces in Iran. Weighted prevalence and associated factors (using Chi-Square test and multivariate logistic regression) were determined by Stata/SE 14.0 survey package. Results: Out of 12,800 prisioners, 11,988 participated in the study (93.6% participation rate). The prevalence of tattooing in lifetime and in prisons was 44.7% and 31.1% respectively. The prevalence of tattooing during lifetime was significantly associated with age < 35 years, being single, illiteracy, history of imprisonment, drug use, piercing during lifetime, extramarital sex and history of STI; the prevalence of tattooing in prison had a significant association with history of imprisonment, drug use, piercing in prison, and history of extramarital sex (p < 0.05). Study limitations: Information and selection bias was one of the study limitations. Conclusion: The results of this study showed that the prevalence of tattooing during lifetime and in prison among prisoners was significantly high especially in high-risk groups such as drug users and sexually active subjects. Given the role of tattooing, drug injection and sex in the transmission of blood-borne diseases, harm reduction programs are recommended to reduce these high-risk behaviors in prisons.

Lifetime prevalence, sociodemographic predictors, and comorbidities of oppositional defiant disorder: the National Epidemiology of Iranian Child and Adolescent Psychiatric disorders (IRCAP)

Objective: This was the first national epidemiological study on oppositional defiant disorder (ODD) in Iran, which provided new information about the prevalence, comorbidities, and sociodemographic predictors of ODD. Methods: Data from a face-to-face household survey of 30,532 children and adolescents aged 6-18 years were collected from across all 31 provinces of Iran using a multistage cluster sampling design. The Persian version of the Kiddie Schedule for Affective Disorders and Schizophrenia for School-Age Children - Present and Lifetime Version (K-SADS-PL) was used in this study. Results: The lifetime prevalence of ODD was found to be 3.9%. ODD was significantly more common in boys than girls and appeared in late adolescence more frequently than in childhood. A lower prevalence of ODD was found among participants who lived in rural areas. ODD is highly likely to co-occur with attention deficit hyperactivity disorder, separation anxiety disorder, generalized anxiety disorder, and depressive disorders. Conclusions: The findings of this national population-based study confirm and extend previous findings on the prevalence, comorbidities, and sociodemographic predictors of ODD.

Life satisfaction and its contributors among noninstitutionalized older people in Tabriz, Islamic Republic of Iran

Background: With the rising growth of the older population, the well-being of older people is an important objective for both economic and health policy.Aims: This study investigates levels of life satisfaction among older people living at home and the factors that influence it.Method: Applying probability proportional to size, a cross-sectional survey was conducted of 1067 older people living in Tabriz, Islamic Republic of Iran. The Satisfaction with Life Scale and the Multidimensional Scale of Perceived Social Sup-port questionnaires were administered. The data were analysed using chi-squared tests and logistic regression.Results: More than half of the participants were dissatisfied with their lives. Female, educated, and active older people reported greater satisfaction than others. Conclusion: The significant positive effects of perceived social support and physical activity rate indicated that social interaction may be as vital as physical activity for the well-being of older people, and that these qualities should be actively promoted among older people in the Islamic Republic of Iran.

Contexte : Compte tenu de l’augmentation croissante de la population âgée, le bien-être de cette tranche d’âge constitue un objectif important pour les politiques économique et sanitaire.Objectifs : La présente étude portait sur les niveaux de satisfaction à l’égard de la vie chez les personnes âgées vivant à domicile et les facteurs qui l’influencent.Méthode : En appliquant une probabilité proportionnelle à la taille, une étude transversale a été menée auprès de 1067 personnes âgées résidant à Tabriz. Les questionnaires correspondant à l’Échelle de satisfaction dans la vie et à l’Échelle multidimensionnelle de soutien social perçu ont été administrés. Les données ont été analysées à l’aide de tests du khi carré et de la régression logistique.Résultats : Plus de la moitié des participants étaient insatisfaits de leur vie. Les femmes âgées, actives et éduquées faisaient état d’un niveau de satisfaction plus élevé que les autres. Conclusion : Les effets positifs significatifs du soutien social perçu et du taux d’activité physique indiquaient que l’interaction sociale peut jouer un rôle aussi essentiel que l’activité physique pour le bien-être des personnes âgées. De ce fait, ces qualités devraient être activement encouragées parmi les personnes âgées en République islamique d’Iran.

Developing a national minimum data set for hospital information systems in the Islamic Republic of Iran

Background: Standardized data collection supports disease information management and leads to better quality of care. The Islamic Republic of Iran lacks a standard data set for data collection in hospitals.Aims: The aim of this study was to design a minimum data set for hospital information systems in the Islamic Republic of Iran.Methods: This study was conducted in 2015. Data sets of other countries, hospital records, hospital information systems and electronic health record systems in the Islamic Republic of Iran were reviewed for data elements for the minimum data set. Data elements were collected using a data extraction form and were categorized into similar classes, which were divided into administrative and clinical sections. The list of data elements was reviewed by experts in technical offices of the Iranian Ministry of Health and Medical Education, and a minimum data set was drawn up.Results: There were nine and 18 data classes in the administrative and clinical sections with a total of 166 and 684 data elements respectively. After review by the expert panel, 159 administrative and 621 clinical data elements were retained as the minimum data set for the Iranian hospital information system.Conclusion: Our dataset can be used by the Iranian health ministry, hospital information system companies and health surveillance centres for more efficient management of health data.

Contexte : La collecte de données standardisées facilite la gestion de l’information sur les maladies et se traduit par une meilleure qualité des soins. La République islamique d’Iran ne dispose pas d’un ensemble de données standard permettant de collecter des données dans les hôpitaux.Objectifs : La présente étude avait pour objectif de mettre au point un ensemble de données minimum destiné aux systèmes d’information hospitaliers en République islamique d’Iran.Méthodes : L’étude a été menée en 2015. Les ensembles de données issus d’autres pays, de dossiers hospitaliers, de systèmes d’information hospitaliers et de systèmes de dossiers médicaux électroniques disponibles en République islamique d’Iran ont été passés en revue afin de sélectionner les éléments à inclure dans l’ensemble de données minimum. Les éléments de données ont été collectés à l’aide d’un formulaire d’extraction, puis classés dans des catégories similaires, elles-mêmes divisées en sections administrative et clinique. La liste des éléments de données a été revue par les experts des services techniques du ministère iranien de la Santé et de l’Enseignement médical, et un ensemble de données minimum a été défini.Résultats : Les sections administrative et clinique comportaient neuf et dix-huit catégories de données, avec un total de 166 et de 684 éléments de données respectivement. Suite à un examen par un groupe d’experts, 159 éléments de données administratives et 621 pour la partie clinique ont été retenus pour constituer l’ensemble de données minimum destiné au système d’information hospitalier iranien.Conclusion : Cet ensemble de données peut être utilisé par le ministère susmentionné, les sociétés en charge des systèmes d’information hospitaliers et les centres de surveillance de la santé pour parvenir à une gestion plus efficace des données sanitaires.

Clinical and laboratory data in pediatric autoimmune hepatitis: study from referral center in Iran / Datos clínicos y de laboratorio en hepatitis autoinmune pediátrica: estudio del centro de referencia en Irán

ABSTARCT Background : Autoimmune hepatitis (AIH) is an auto-inflammatory liver disease of children and adults, affecting patients of any age, sex, race or ethnicity, with more prevalence in females. Objective : The aim of this study was to evaluate clinical manifestation, laboratory findings, and outcome of children with autoimmune hepatitis. Materials and methods : We evaluated 86 patients treated and followed with final diagnosis of AIH between years 2010 to 2018. Physical findings (including jaundice, hepatomegaly, splenomegaly and encephalopathy), liver enzymes, liver histology and autoantibodies (including ANA, Anti LKM-1 and ASMA) were extracted from medical files. Then the patients were followed for their final outcome (including response to medical treatment or successful treatment withdrawal, liver transplantation or death). Results : Among 86 patients with AIH with mean age 9.10±4.36 years old, 66.27% were females. Jaundice (75.6%) and hepatomegaly (46.5%) were the most frequent physical findings, followed by splenomegaly (32.6%) and encephalopathy (17.4%). Aminotransferases including AST and ALT were elevated at least 3 times more than upper limit of normal in most of the patients (61.6% and 55.81%, respectively). Autoantibodies were available in 53 of 86 patients, 24.5% had AIH-1, 3.8% had AIH-II and 67.9% were seronegative. Medical treatment including prednisolone and azathioprine was started for patients, 53 of 86 cases (61.6%) had remission and 11 of 86 (13.7%) tolerated medication withdrawal successfully. Among all cases, 26 (30.2%) patients needed liver transplantation. Mortality rate was 9 among 86 cases (10.5%). Conclusion : Jaundice and hepatomegaly was the most frequent clinical findings. Mortality rate was 10.5%.

RESUMEN Antecedentes : La hepatitis autoinmune (AIH) es una enfermedad hepática autoinflamatoria de niños y adultos, que afecta a pacientes de cualquier edad, sexo, raza u origen étnico, con mayor prevalencia en las mujeres. Objetivo : El objetivo de este estudio fue evaluar la manifestación clínica, los hallazgos de laboratorio y el resultado de los niños con hepatitis autoinmune. Materiales y métodos : Evaluamos 86 pacientes tratados y seguidos con el diagnóstico final de AIH entre los años 2010 a 2018. Los hallazgos físicos (incluyendo ictericia, hepatomegalia, esplenomegalia y encefalopatía), enzimas hepáticas, histología hepática y autoanticuerpos (incluidos ANA, Anti LKM-1 y ASMA) se extrajeron de las historias médicas. Luego, los pacientes fueron seguidos para su resultado final (incluida la respuesta al tratamiento médico o la retirada exitosa del tratamiento, el trasplante de hígado o la muerte). Resultados : Entre 86 pacientes con AIH con una edad media de 9,10 ± 4,36 años, el 66,27% eran mujeres. La ictericia (75,6%) y la hepatomegalia (46,5%) fueron los hallazgos físicos más frecuentes, seguidos de esplenomegalia (32,6%) y encefalopatía (17,4%). Las aminotransferasas que incluyen AST y ALT se elevaron al menos 3 veces más que el límite superior de la normalidad en la mayoría de los pacientes (61,6% y 55,81%, respectivamente). Los autoanticuerpos estaban disponibles en 53 de 86 pacientes, 24,5% tenían AIH-1, 3,8% tenían AIH-II y 67,9% eran seronegativos. Se inició tratamiento médico que incluyó prednisolona y azatioprina, 53 de 86 casos (61,6%) tuvieron remisión y 11 de 86 (13,7%) toleraron el retiro de medicamentos con éxito. Entre todos los casos, 26 (30,2%) pacientes necesitaron un trasplante de hígado. La tasa de mortalidad fue de 9 entre 86 casos (10,5%). Conclusión : la ictericia y la hepatomegalia fueron los hallazgos clínicos más frecuentes. La tasa de mortalidad fue del 10,5%.

Validation of an Ultrashort Persian Version of Oral Health Impact Profile (OHIP-5) Questionnaire

Abstract Objective: To validate the ultrashort (5-item) Persian version of OHIP by investigating its psychometric properties. Material and Methods: Construct validity was assessed by examining the correlation between OHIP-5 scores and self-reported oral health status, judgment for dental treatment needs and the number of natural teeth. Reliability was calculated using Cronbach's alpha and corrected item-total correlation. Effect size (ES) and Standardized Response Mean (SRM) were calculated for the responsiveness of the scale and factor analysis was done by measuring Kaiser-Meyer-Olkin (KMO), Bartlett's sphericity test and scree plot. Results: In 430 subjects (mean age 41.56+/-11.35 years, 56% female) the correlations between OHIP-5 scores and mentioned items were significant (p<0.01) indicating sufficient construct validity. The reliability coefficient (Cronbach's alpha) of the OHIP-5 was above the recommended 0.7 thresholds (0.809) and considered well. For evaluation of responsiveness, the ES was measured to be 5.604 and the SRM was 1.5. Moreover, in the confirmatory factor analysis, the unidimensional model for OHIP5 approved by indices (KMO=0.81, p<0.001 for Bartlett sphericity). Conclusion: The Persian version of OHIP-5 is a precise, valid, reliable and unidimensional instrument for assessing oral health-related quality of life among the general adult population.

Comparing the Levels of Gingival Crevicular Fluid Prostaglandin E2 in Generalized Chronic Periodontitis Between Healthy and Type 2 Diabetes Patients: A Case-Control Study

Objective: To compare the prostaglandin E2 (PGE2) levels of gingival crevicular fluid in generalized chronic periodontitis between healthy and type 2 diabetic patients. Material and Methods: 56 diabetic and non-diabetic participants with generalized chronic periodontitis were selected randomly. They were divided into two groups (G1: generalized chronic periodontitis patients with normal blood sugar; and G2: generalized chronic periodontitis patients with diabetes). Gingival crevicular fluid samples were obtained from both groups. The average of 2 samples per day were centrifuged in a laboratory at 2500 rpm and temperature of 4°C for 5 minutes and placed in a refrigerator at -20°C. The level of PGE2 was measured using ELISA and Abcam kit. Data were analyzed by Kolmogorov-Smirnov, Mann-Whitney U Test, Pearson and independent T tests. The significant amount was considered 0.05 in this test (α<0.05). Results: The mean level of PGE2 was significantly different in the two groups and the mean level of PGE2 in the control group was lower than the case group. There was no statistically significant relationship between PGE2 with pocket depth, fasting blood sugar (FBS) and HBA1C (p>0.05). Conclusion: PGE2 level of diabetic patient group with chronic generalized periodontitis was significantly more than non-diabetic group with generalized chronic periodontitis.

Successful implementation of general health policies in the Islamic Republic of Iran: barriers and mechanisms

Background: The general health policies for the Islamic Republic of Iran were approved in April 2014.Aims: This study examined the barriers currently faced by general health policies and the mechanisms required for the successful implementation of these polices.Methods: This qualitative study was conducted as a two-phase project based on standard CAN-IMPLEMENT guidelines. A set of qualitative methods, including face-to-face in-depth interviews, focus groups, and in-person consensus meetings, were used to clarify mechanisms and barriers.Results: Twenty-one mechanisms and 13 barriers were identified. The majority of mechanisms were related to the development of health infrastructures and appropriate allocation of resources. The most significant barriers to implementation of general health policies were lack of formulated strategies, poor management, lack of a comprehensive national action plan, minimal information infrastructures, and inadequate fundingConclusions: A thorough understanding of barriers and mechanisms for implementation of general health policies can provide the necessary background to ensure successful health promotion in the country.

Contexte : Les politiques générales de santé de la République islamique d’Iran ont été approuvées en avril 2014 .Objectif : La présente étude a examiné les barrières auxquelles se heurtent actuellement les politiques générales de santé, ainsi que les mécanismes requis pour assurer le succès de leur mise en œuvre.Méthodes : Il s’agissait d’une étude qualitative menée dans le cadre d’un projet en deux phases reposant sur les directives CAN-IMPLEMENT©. Un ensemble de méthodes qualitatives, incluant des entretiens approfondis en face-à-face, des groupes de discussion et des réunions de consensus, ont été utilisées afin de déterminer les mécanismes et les barrières à ce sujet.Résultats : Vingt et un mécanismes et treize barrières ont été identifiés. Dans leur majorité, les mécanismes étaient liés à la mise en place d’infrastructures de santé et à une allocation adéquate des ressources. Les barrières les plus significatives à la mise en œuvre des politiques générales de santé étaient un manque de stratégies efficaces, une mauvaise gestion, l’absence de plan d’action national complet, des infrastructures d’information limitées, et un financement insuffisant.Conclusion : Une compréhension approfondie des barrières et des mécanismes pour la mise en œuvre des politiques générales de santé peut fournir le contexte nécessaire afin d’assurer une promotion de la santé réussie dans le pays.

Socioeconomic inequality in childhood obesity and its determinants: a Blinder-Oaxaca decomposition / Desigualdade socioeconômica na obesidade infantil e seus determinantes: decomposição de Oaxaca-Blinder

Abstract Objective Childhood obesity has become a priority health concern worldwide. Socioeconomic status is one of its main determinants. This study aimed to assess the socioeconomic inequality of obesity in children and adolescents at national and provincial levels in Iran. Methods This multicenter cross-sectional study was conducted in 2011-2012, as part of a national school-based surveillance program performed in 40,000 students, aged 6-18-years, from urban and rural areas of 30 provinces of Iran. Using principle component analysis, the socioeconomic status of participants was categorized to quintiles. Socioeconomic status inequality in excess weight was estimated by calculating the prevalence of excess weight (i.e., overweight, generalized obesity, and abdominal obesity) across the socioeconomic status quintiles, the concentration index, and slope index of inequality. The determinants of this inequality were determined by the Oaxaca Blinder decomposition. Results Overall, 36,529 students completed the study (response rate: 91.32%); 50.79% of whom were boys and 74.23% were urban inhabitants. The mean (standard deviation) age was 12.14 (3.36) years. The prevalence of overweight, generalized obesity, and abdominal obesity was 11.51%, 8.35%, and 17.87%, respectively. The SII for overweight, obesity and abdominal obesity was -0.1, -0.1 and -0.15, respectively. Concentration index for overweight, generalized obesity, and abdominal obesity was positive, which indicate inequality in favor of low socioeconomic status groups. Area of residence, family history of obesity, and age were the most contributing factors to the inequality of obesity prevalence observed between the highest and lowest socioeconomic status groups. Conclusion This study provides considerable information on the high prevalence of excess weight in families with higher socioeconomic status at national and provincial levels. These findings can be used for international comparisons and for healthcare policies, improving their programming by considering differences at provincial levels.

Resumo Objetivo A obesidade infantil se tornou uma preocupação de saúde prioritária em todo o mundo. A situação socioeconômica (SSE) é um de seus principais determinantes. Este estudo tem como objetivo avaliar a desigualdade socioeconômica com relação à obesidade entre crianças e adolescentes em nível nacional e subnacional no Irã. Métodos Este estudo transversal multicêntrico foi conduzido em 2011-2012 como parte de um programa nacional de vigilância escolar realizado com 40000 alunos, com idade entre 6-18 anos, de áreas urbanas e rurais de 30 províncias do Irã. Utilizando a análise de componentes principais, a SSE dos participantes foi categorizada em quintis. A desigualdade da SSE no excesso de peso foi estimada pelo cálculo da prevalência de excesso de peso (ou seja, sobrepeso, obesidade geral e obesidade abdominal) em todos os quintis da SSE, o índice de concentração (C) e o slope index of inequality (SII). Os determinantes dessa desigualdade foram determinados pela decomposição de Oaxaca-Blinder. Resultados No total, 36529 alunos completaram o estudo (taxa de resposta: 91,32%), dos quais 50,79% eram meninos e 74,23%, habitantes urbanos. A idade média (DP) foi 12,14 (3,36) anos. A prevalência de sobrepeso, obesidade geral e obesidade abdominal foi 11,51%, 8,35% e 17,87%, respectivamente. A SSE com relação a sobrepeso, obesidade e obesidade abdominal foi -0,1, -0,1 e -0,15, respectivamente. O índice C com relação a sobrepeso, obesidade geral e obesidade abdominal foi positivo, o que indica que a desigualdade estava em favor de grupos de baixa SSE. A área de residência, o histórico familiar de obesidade e a idade foram os fatores que mais contribuíram para a desigualdade da prevalência de obesidade observados entre os grupos em SSE mais alta e mais baixa. Conclusão Este estudo fornece informações consideráveis sobre a alta prevalência de excesso de peso em famílias em SSE mais alta em nível nacional e subnacional. Esses achados podem ser usados para comparações internacionais e políticas de saúde, melhorar a programação ao considerar as diferenças em nível subnacional.

External validation of european system for cardiac operative risk evaluation II (euroscore II) for risk prioritization in an iranian population

Abstract Introduction: The European System for Cardiac Operative Risk Evaluation II (EuroSCORE II) is a prediction model which maps 18 predictors to a 30-day post-operative risk of death concentrating on accurate stratification of candidate patients for cardiac surgery. Objective: The objective of this study was to determine the performance of the EuroSCORE II risk-analysis predictions among patients who underwent heart surgeries in one area of Iran. Methods: A retrospective cohort study was conducted to collect the required variables for all consecutive patients who underwent heart surgeries at Emam Reza hospital, Northeast Iran between 2014 and 2015. Univariate and multivariate analysis were performed to identify covariates which significantly contribute to higher EuroSCORE II in our population. External validation was performed by comparing the real and expected mortality using area under the receiver operating characteristic curve (AUC) for discrimination assessment. Also, Brier Score and Hosmer-Lemeshow goodness-of-fit test were used to show the overall performance and calibration level, respectively. Results: Two thousand five hundred eight one (59.6% males) were included. The observed mortality rate was 3.3%, but EuroSCORE II had a prediction of 4.7%. Although the overall performance was acceptable (Brier score=0.047), the model showed poor discriminatory power by AUC=0.667 (sensitivity=61.90, and specificity=66.24) and calibration (Hosmer-Lemeshow test, P<0.01). Conclusion: Our study showed that the EuroSCORE II discrimination power is less than optimal for outcome prediction and less accurate for resource allocation programs. It highlights the need for recalibration of this risk stratification tool aiming to improve post cardiac surgery outcome predictions in Iran.

Further evidence of psychological factors underlying choice of elective cesarean delivery (ECD) by primigravidae

Objective: Requests for elective cesarean delivery (ECD) have increased in Iran. While some sociodemographic and fear-related factors have been linked with this choice, psychological factors such as self-esteem, stress, and health beliefs are under-researched. Methods: A total of 342 primigravidae (mean age = 25 years) completed questionnaires covering psychological dimensions such as self-esteem, perceived stress, marital relationship quality, perceived social support, and relevant health-related beliefs. Results: Of the sample, 214 (62.6%) chose to undergo ECD rather than vaginal delivery (VD). This choice was associated with lower self-esteem, greater perceived stress, belief in higher susceptibility to problematic birth and barriers to an easy birth, along with lower perceived severity of ECD, fewer perceived benefits from VD, lower self-efficacy and a lower feeling of preparedness. No differences were found for marital relationship quality or perceived social support. Conclusions: The pattern suggests that various psychological factors such as self-esteem, self-efficacy, and perceived stress underpin the decision by primigravidae to have an ECD.

Referral system in rural Iran: improvement proposals / O sistema de encaminhamento de pacientes na zona rural do Irã: propostas para melhorias / Sistema de derivación sanitario en zonas rurales de Irán: propuestas de mejora

Because of insufficient communication between primary health care providers and specialists, which leads to inefficiencies and ineffectiveness in rural population health outcomes, to implement a well-functioning referral system is one of the most important tasks for some countries. Using purposive and snowballing sampling methods, we included health experts, policy-makers, family physicians, clinical specialists, and experts from health insurance organizations in this study according to pre-determined criteria. We recorded all interviews, transcribed and analyzed their content using qualitative methods. We extracted 1,522 individual codes initially. We also collected supplementary data through document review. From reviews and summarizations, four main themes, ten subthemes, and 24 issues emerged from the data. The solutions developed were: care system reform, education system reform, payment system reform, and improves in culture-building and public education. Given the executive experience, the full familiarity, the occupational and geographical diversity of participants, the solutions proposed in this study could positively affect the implementation and improvement of the referral system in Iran. The suggested solutions are complementary to each other and have less interchangeability.

Devido à comunicação insuficiente entre os profissionais de saúde na atenção primária e os especialistas, levando a ineficiências e ineficácias nos desfechos de saúde na população rural, a implementação de um sistema funcional de referência e contra-referência é uma das tarefas mais importantes para alguns países. Com o uso de métodos propositais e de "bola de neve", o estudo incluiu especialistas em saúde pública, gestores, especialistas clínicos e representantes de planos de saúde, de acordo com critérios predeterminados. Gravamos e transcrevemos todas as entrevistas, e depois analisamos o conteúdo através de métodos qualitativos. Inicialmente extraímos 1.522 códigos individuais. Também coletamos dados complementares através da revisão de documentos. A partir das revisões e resumos, emergiram dados sobre quatro temas principais, dez subtemas e 24 questões. Foram desenvolvidas as seguintes soluções: reforma do sistema de atenção, reforma do sistema de ensino, reforma do sistema de remuneração e melhorias na construção de cultura e no ensino público. Em função da experiência executiva, a familiaridade plena e a diversidade ocupacional e geográfica dos participantes, as soluções propostas pelo estudo poderiam impactar positivamente a implementação e melhoria do sistema de encaminhamento de pacientes no Irã. As soluções propostas se complementam e são menos intercambiáveis.

Debido a la insuficiente comunicación entre los responsables de la atención primaria y los especialistas, se producen ineficiencias y falta de eficacia en las condiciones de salud de la población rural iraní. Por ello, implementar un buen sistema de derivación sanitario es una de las tareas más importantes para algunos países. Usando un método de muestreo intencional y de bola de nieve, incluimos a expertos en salud, formuladores de políticas, médicos de familia, especialistas clínicos, y expertos del ámbito de las empresas de seguros de salud en este estudio, de acuerdo con criterios predeterminados. Grabamos todas las entrevistas, transcribimos y analizamos su contenido usando métodos cualitativos. En un principio se seleccionaron 1.522 códigos individuales. También obtuvimos datos complementarios a través de la revisión de documentación. Fruto de las revisiones y puestas en común, se obtuvieron 4 temas principales, 10 subtemas y 24 cuestiones que afloraron de estos datos. Las soluciones desarrolladas fueron: reforma del sistema de atención, reforma del sistema educativo, reforma del sistema de pago, y mejoras en la educación cultural y pública. Dada la experiencia ejecutiva, la gran sinceridad en las respuestas, la diversidad ocupacional y geográfica de los participantes, las soluciones propuestas en este estudio pueden afectar positivamente la implementación y mejora del sistema de derivación sanitario en Irán. Las soluciones sugeridas son complementarias entre ellas, aunque poseen una menor intercambiabilidad entre sí.

Association between TGFß1 polymorphisms and chronic hepatitis B infection in an Iranian population

Abstract INTRODUCTION: Transforming growth factor-beta 1 (TGFβ1) is a potent suppressive cytokine that contributes to chronic hepatitis B (CHB) infection. Disparities in TGFβ1 production among individuals have been attributed to TGFβ1 genetic polymorphisms. We examined whether three putative polymorphisms in TGFβ1[-509 C/T (rs1800469), +869 C/T (rs1800470), and +11929 C/T (rs1800472)]are associated with CHB infection in a South-Eastern Iranian population. METHODS: In total, 341 subjects were recruited, including 178 patients with CHB and 163 healthy individuals as controls. Genotyping of the three TGFβ1 SNPs was performed by tetra amplification refractory mutation system-PCR. RESULTS: TheTGFβ1 +869 TT vs.CC genotype in codominant (OR=0.445, p=0.012) and TT vs. TC+CC in the recessive (OR=0.439, p=0.003) model as well as the variant allele T vs. C(OR=0.714, p=0.038) were associated with lower CHB infection risk. However, the +11929 C/T polymorphism was associated with increased CHB risk, and the CT vs. CC genotype (OR=2.77, P=0.001) and T variant allele (OR=2.53, P=0.002) were risk factors for CHB. Furthermore, TTT (+869/-509/+11929) and CCC haplotypes were risk and protective factors for CHB, respectively. We found no significant association between viral DNA load and TGFβ1 genotype or hepatic enzyme levels (p >0.05). CONCLUSIONS: Results indicated that the TGFβ1+869TT genotype and T allele were protective factors, whereas the +11929 CT genotype and T allele were risk factors for CHB infection.

Assessing the quality of referral letters written by general practitioners: a cross-sectional study in rural Iran / Avaliação da qualidade de cartas de encaminhamento escritas por clínicos gerais: um estudo transversal numa área rural do Irã / Evaluación de la calidad de cartas de derivación escritas por médicos generales: un estudio transversal en un área rural de Irán

Abstract: Establishing effective communication between general practitioners (GPs) and medical specialists is a key component of the referral system. Written communication between GPs and medical specialists is the most common communication tool. This study was conducted to evaluate quality (information content) of the referral letters written by GPs and addressed to gynecologists and cardiologists. We evaluated quality of the referral letters through a cross-sectional study in the villages of Sarab city, located in East Azerbaijan Province, Northwest Iran. The study was conducted during August and September 2015 in which a total of 400 referral letters were evaluated according to specific quality criteria. Cluster sampling was implemented and data were collected using an instrument designed by the Department of Family Medicine at the University of Manitoba, Canada. A specifically designed referral form was used to refer pregnant women to gynecologists. Referrals addressed to gynecologists showed better quality in comparison to cases referred to cardiologists. Legibility of referral letters was 73%. It is recommended that agreed-upon referral letters be designed cooperatively for different groups of diseases. Furthermore, primary health care providers should be trained to write proper referral letters.

Resumo: Um componente essencial do sistema de encaminhamento de pacientes é a comunicação efetiva entre clínicos gerais e especialistas. A comunicação escrita é a ferramenta de comunicação mais comum entre clínicos gerais e especialistas. O estudo teve como objetivo avaliar a qualidade (conteúdo da informação) de cartas de encaminhamento escritas por clínicos gerais e dirigidas a ginecologistas e cardiologistas. Os autores avaliaram a qualidade das cartas de encaminhamento através de um estudo transversal em aldeias em torno da cidade de Sarab, localizada na Província de Azerbaijão Oriental, no Noroeste do Irã. O estudo foi realizado em agosto e setembro de 2015, quando 400 cartas de encaminhamento foram avaliadas com base em critérios específicos de qualidade. O estudo adotou a amostragem por aglomerados, e os dados foram coletados através de um instrumento desenvolvido pelo Departamento de Medicina Familiar da Universidade de Manitoba, Canadá. Um formulário foi projetado especificamente para encaminhar as mulheres à ginecologia. As cartas de encaminhamento para a ginecologia mostraram qualidade superior quando comparadas aos casos encaminhados à cardiologia. A proporção de cartas legíveis foi 73%. Recomenda-se que cartas de encaminhamento sejam desenvolvidas em cooperação entre os departamentos, para diferentes grupos de doenças. Além disso, os médicos de atenção primária devem ser capacitados para redigir cartas de encaminhamento adequadas.

Resumen: Un componente esencial del sistema de derivación de pacientes es la comunicación efectiva entre médicos generales y especialistas. La comunicación escrita es la herramienta de comunicación más común entre médicos generales y especialistas. El estudio tuvo como objetivo evaluar la calidad (contenido de la información) de cartas de derivación escritas por médicos generales y dirigidas a ginecólogos y cardiólogos. Los autores evaluaron la calidad de las cartas de derivación, a través de un estudio transversal en aldeas en torno a la ciudad de Sarab, localizada en la provincia de Azerbaiyán Oriental, en el noroeste de Irán. El estudio se realizó entre agosto y setiembre de 2015, cuando 400 cartas de derivación se evaluaron en base a criterios específicos de calidad. El estudio adoptó la muestra por aglomerados y los datos se recogieron a través de un instrumento desarrollado por el Departamento de Medicina Familiar de la Universidad de Manitoba, Canadá. Se proyectó un formulario específicamente para derivar a las mujeres a ginecología. Las cartas de derivación para ginecología mostraron calidad superior, cuando se comparan a los casos derivados a cardiología. La proporción de cartas legibles fue de un 73%. Se recomienda que las cartas de derivación sean desarrolladas en cooperación entre los departamentos, para diferentes grupos de enfermedades. Asimismo, los médicos de atención primaria deben estar capacitados para reenviar cartas de derivación adecuadas.