Caries experience and salivary aspects in individuals with fragile X syndrome

Abstract Fragile X syndrome (FXS) is the most common cause of hereditary mental retardation, but studies on the oral health condition of these patients are rare. The aim of this study was to determine the experience of dental caries in individuals with FXS, by examining the saliva profile, oral hygiene, socioeconomic characteristics and use of controlled drugs in these patients. Dental health was estimated using the decayed, missing and filled teeth index (DMF-T) and sialometry, and the pH value and buffering capacity of the saliva, colony forming units of S. mutans (CFU/mL), visible biofilm index, and socioeconomic status were all examined. The sample, comprising 23 individuals, had an average age of 17.3 ± 5.6 years, a DMF-T index of 5.5, a diminished salivary flow (78.3%), and a low (73.9%) saliva buffering capacity. Most (52.2%) individuals presented with a high abundance (CFU/mL) of S. mutans. The experience of caries was correlated with salivary parameters, poor oral hygiene, lower socioeconomic status and an increased count of S. mutans in saliva.

Recuento de Streptococci mutans en la saliva de mujeres embarazadas de la región metropolitana: estudio transversal / Counting of salivary streptococci mutans in pregnant women of the metropolitan region of Chile

Background: Salivary Streptococci mutans contamination is considered the main microbiological risk factor for the initiation of caries. Aim: To assess the oral health of pregnant women, counting Salivary Streptococci mutants. Patients and methods: One hundred seventy four pregnant women, in the first, second and third trimester of pregnancy, aged 27 ñ 5 years old, consulting at a public primary health center, were studied. Puerperal women that had their delivery two months before, were studied as a control group. Salivary samples were obtained and Streptococci mutans colonies were counted using quantitative and semiquantitative methods. Results: There was a good concordance between both counting methods. No differences in Streptococci mutans counts were observed among the three groups of pregnant women, but the latter as a group had higher counts than puerperal women. Women with more than 5 caries had also higher counts. Conclusions: Semiquantitative Streptococci mutans counts are easy, rapid and non invasive and have a good concordance with quantitative counts in saliva