HPA-1a/1b could be considered a molecular predictor of poor prognosis in chronic hepatitis C
Rev. Soc. Bras. Med. Trop
; 52: e20170427, 2019. tab
Article
em En
| LILACS
| ID: biblio-1041583
Biblioteca responsável:
BR1.1
ABSTRACT
Abstract INTRODUCTION: HPA polymorphism has been associated with HCV presence and fibrosis progression in chronic hepatitis C. However, it is unknown if there is an association between HPA-1 polymorphism and hepatocellular carcinoma (HCC). Therefore, this study aimed to evaluate HPA-1 polymorphism in the presence of HCC. METHODS: PCR-SSP was used to perform HPA genotyping on 76 HCV-infected patients. RESULTS: There was no association between patients with and without HCC. There was significant difference in HPA-1 genotypic frequency distribution between HCC and F1/F2 fibrosis degree. CONCLUSIONS: The HPA-1a/1b polymorphism appears to be more associated with liver damage progression than with HCC presence.
Palavras-chave
Texto completo:
1
Temas:
Informacoes_doencas_cronicas_degenerativas
Base de dados:
LILACS
Assunto principal:
Antígenos de Plaquetas Humanas
/
Carcinoma Hepatocelular
/
Hepatite C Crônica
/
Neoplasias Hepáticas
Idioma:
En
Revista:
Rev. Soc. Bras. Med. Trop
Assunto da revista:
MEDICINA TROPICAL
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Brasil