Treatment of chronic hepatitis C in patients with chronic kidney disease with Sofosbuvir-basead regimes
Braz. j. infect. dis
; 24(1): 25-29, Feb. 2020. tab, graf
Artigo
em Inglês
| LILACS
| ID: biblio-1089328
Biblioteca responsável:
BR1.1
ABSTRACT
ABSTRACT Background: To analyze the effectiveness and the safety of Sofosbuvir-based regimens to treat patients with chronic hepatitis C virus (HCV) infection and chronic kidney disease (CKD). Methods: A retrospective, observational study in patients with chronic HCV infection and CKD treated with Sofosbuvir-based regimens was performed. Liver fibrosis, comorbidities, HCV genotype and sustained virological resposnse (SVR) at 12th week post-treatment were evaluated. Kidney function was accessed by serum creatinine and glomerular filtration rate (GFR). The assumed level of significance was 5 %. Results: Thirty-five patients were treated. The mean age was 52.1 ± 10.9 years, 19 (54.3 %) were women, 32 (91.4 %) were already kidney transplanted and 3 (8.6 %) were on hemodialysis. The SVR by intention to treat was 88.6 %. The mean GFR was 65.8 ± 28.6 and 63.7 ± 28.3 ml/min pre- and post-treatment respectively (p > 0.05). Treatment was interrupted in 1 (2.85 %) patient due to anemia and in 2 (5.7 %) due to loss of kidney function. Conclusion: Sofosbuvir-based regimens are effective to treat HCV in patients with CKD. In patients with mild CKD this type of therapy seems to be safe.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Temas:
Doenças crônicas e degenerativas
/
Saúde do idoso
Base de dados:
LILACS
Assunto principal:
Antivirais
/
Hepatite C Crônica
/
Insuficiência Renal Crônica
/
Sofosbuvir
Idioma:
Inglês
Revista:
Braz. j. infect. dis
Assunto da revista:
Doenças Transmissíveis
Ano de publicação:
2020
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA)/BR
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