Renal vascular and excretory resistance to atrial natriuretic peptide in pre-cirrhotic, bile-duct ligated rats
Biol. Res
; 26(3): 397-404, 1993. ilus
Article
em En
| LILACS
| ID: lil-228594
Biblioteca responsável:
BR1.1
RESUMO
Renal response to atrial natriuretic peptide in chronic cholestasis was studied in anaesthetized rats and in their isolated perfused kidneys. Cholestasis was induced by bile duct section after ligature, while controls were sham operated. Three weeks after surgery, cholestatic rats showed moderate arterial hypotension, elevated diuresis and no differences in urinary sodium, glomerular filtration rate (GFR) and fractional sodium excretion (FENa), when compared to controls. Isolated kidneys of cholestatic rats had equal basal diuresis and less natriuresis than the controls. Cholestatic rats presented blunted natriuretic and diuretic responses to iv injections of atrial natriuretic peptide (ANP 0.5 microgram), associated with reduced increments in GFR and FENa, when compared with controls. Similarly, the diuretic-natriuretic response of isolated kidneys to ANP (3.5 x 10(-9) M) was greatly attenuated in this group. ANP did not increase perfusion pressure in cholestatic rats, as it did in controls. These results indicate that animals with chronic cholestasis present refractoriness to ANP, which might be mediated by a direct impairment at the renal vascular and tubular sites for ANP action
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Temas:
Informacoes_doencas_cronicas_degenerativas
Base de dados:
LILACS
Assunto principal:
Resistência Vascular
/
Colestase
/
Fator Natriurético Atrial
/
Rim
Idioma:
En
Revista:
Biol. Res
Assunto da revista:
BIOLOGIA
Ano de publicação:
1993
Tipo de documento:
Article