Possible analgesic effect of vigabrin in animal experimental chronic neuropathic pain
Arq. neuropsiquiatr
; 57(4): 916-20, dez. 1999. graf
Article
em En
| LILACS
| ID: lil-249288
Biblioteca responsável:
BR1.1
RESUMO
Since anticonvulsants have been used for treating neuralgias, an interest has arisen to experimentally test vigabatrin for its gabaergic mechanism of action. For this, 41 Wistar rats were used, and in 25 of them a constractive sciatic neuropathy was induced (Bennet & Xie model). For testing pain symptoms, spontaneous (Scratching) and evoked behaviors to noxious (46 degrees Celsius) and non-noxious (40 degrees Celsius) thermal stimuli were quatified. Moreover, a comparative pharmacological study of vigabatrin with other analgesic anticonvulsant drugs was also performed. The results showed a possible dose-dependent analgesic effect of vigabatrin (gamma-vinyl-GABA) on experimental neuropathic pain, as shown vy the significant (p<0.05) decreasing effect of vigabatrin on scratching and by its significant (p>0.05) increasing effect on the latency of the right hindpaw withdrawal of the animals to noxious thermal stimulus. This was corroborated by similar findings with analgesic anticonvulsants (carbamazepine, phenytoin and valproic acid). This possible and not yet described analgesic effect of vigabatrin seems not to be opioid mediated.
Texto completo:
1
Temas:
Informacoes_doencas_cronicas_degenerativas
Base de dados:
LILACS
Assunto principal:
Vigabatrina
/
Analgésicos
/
Anticonvulsivantes
/
Neuralgia
Idioma:
En
Revista:
Arq. neuropsiquiatr
Assunto da revista:
NEUROLOGIA
/
PSIQUIATRIA
Ano de publicação:
1999
Tipo de documento:
Article