Impairment of cytomegalovirus-specific cellular immune response as a risk factor for cytomegalovirus disease in transplant recipients: [review]
Braz. j. med. biol. res
; 41(1): 5-11, Jan. 2008. ilus
Article
em En
| LILACS
| ID: lil-469970
Biblioteca responsável:
BR1.1
ABSTRACT
Human cytomegalovirus (CMV) infection is common in most people but nearly asymptomatic in immunocompetent individuals. After primary infection the virus persists throughout life in a latent form in a variety of tissues, particularly in precursor cells of the monocytic lineage. CMV reinfection and occurrence of disease are associated with immunosuppressive conditions. Solid organ and bone marrow transplant patients are at high risk for CMV disease as they undergo immunosuppression. Antiviral treatment is effective in controlling viremia, but 10-15 percent of infected patients can experience CMV disease by the time the drug is withdrawn. In addition, long-term antiviral treatment leads to bone marrow ablation and renal toxicity. Furthermore, control of chronic CMV infection in transplant recipients appears to be dependent on the proper recovery of cellular immunity. Recent advances in the characterization of T-cell functions and identification of distinct functional signatures of T-cell viral responses have opened new perspectives for monitoring transplant individuals at risk of developing CMV disease.
Palavras-chave
Texto completo:
1
Temas:
Informacoes_doencas_cronicas_degenerativas
Base de dados:
LILACS
Assunto principal:
Linfócitos T
/
Transplante de Medula Óssea
/
Hospedeiro Imunocomprometido
/
Infecções por Citomegalovirus
/
Citomegalovirus
Idioma:
En
Revista:
Braz. j. med. biol. res
Assunto da revista:
BIOLOGIA
/
MEDICINA
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Brasil