Epidemiological aspects of hepatitis C virus infection among renal transplant recipients in Central Brazil
Mem. Inst. Oswaldo Cruz
; 103(5): 472-476, Aug. 2008. graf, tab
Artigo
em Inglês
| LILACS
| ID: lil-491970
Biblioteca responsável:
BR1.1
ABSTRACT
An investigation was conducted involving 255 renal transplant recipients in the state of Goiás, Central Brazil, to determine the prevalence of hepatitis C virus (HCV), its risk factors, the genotypes involved, and the level of alanine aminotransferase (ALT) present in the patients. All serum samples were tested for anti-HCV antibodies and HCV RNA. Forty-one patients were anti-HCV and/or HCV RNA positive, resulting in an overall HCV infection prevalence of 16.1 percent (95 percent CI: 11.9-21.3). A multivariate analysis of risk factors showed that a history of blood transfusions without anti-HCV screening, the length of time spent on hemodialysis, and renal transplantation before 1994 are all associated with HCV positivity. In HCV-positive patients, only 12.2 percent had ALT levels above normal. Twenty-eight samples were genotyped as genotype 1, subtypes 1a (62.5 percent) and 1b (31.3 percent), and two samples (6.2 percent) were genotype 3, subtype 3a. These data show a high prevalence of HCV infection and low ALT levels in the studied population. The risk factor analysis findings emphasize the importance of public health strategies such as anti-HCV screening of candidate blood and organ donors, in addition to the stricter adoption of hemodialysis-specific infection control measures. The present study also demonstrates that HCV genotype 1 (subtype 1a) is predominant in this population.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Temas:
Doenças crônicas e degenerativas
/
Saúde do idoso
Base de dados:
LILACS
Assunto principal:
Transplante de Rim
/
Hepatite C
/
Hepacivirus
/
Anticorpos Anti-Hepatite C
Idioma:
Inglês
Revista:
Mem. Inst. Oswaldo Cruz
Assunto da revista:
Medicina Tropical
/
Parasitologia
Ano de publicação:
2008
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Fiocruz/BR
/
Universidade Federal de Goiás/BR
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