Microbiological and host features associated with corynebacteriosis in cancer patients: a five-year study
Mem. Inst. Oswaldo Cruz
; 104(6): 905-913, Sept. 2009. tab
Article
em En
| LILACS
| ID: lil-529562
Biblioteca responsável:
BR1.1
ABSTRACT
During a five-year period, 932 clinical isolates from cancer patients treated in a Brazilian reference centre were identified as corynebacteria; 86 percent of the cultures came from patients who had been clinically and microbiologically classified as infected and 77.1 percent of these patients had been hospitalised (71.1 percent from surgical wards). The adult solid tumour was the most common underlying malignant disease (66.7 percent). The univariate and multivariate analyses showed that hospitalised patients had a six-fold greater risk (OR = 5.5, 95 percent CI = 1.15-26.30 p = 0.033) related to 30-day mortality. The predominant species were Corynebacterium amycolatum (44.7 percent), Corynebacterium minutissimum (18.3 percent) and Corynebacterium pseudodiphtheriticum (8.5 percent). The upper urinary tracts, surgical wounds, lower respiratory tracts, ulcerated tumours and indwelling venous catheters were the most frequent sources of C. amycolatum strains. Corynebacterium jeikeium infection occurred primarily in neutropenic patients who have used venous catheters, while infection caused by C. amycolatum and other species emerged mainly in patients with solid tumours.
Palavras-chave
Texto completo:
1
Temas:
Saude_idoso
Base de dados:
LILACS
Assunto principal:
Infecção Hospitalar
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Corynebacterium
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Infecções por Corynebacterium
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Infecções Relacionadas a Cateter
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Neoplasias
Idioma:
En
Revista:
Mem. Inst. Oswaldo Cruz
Assunto da revista:
MEDICINA TROPICAL
/
PARASITOLOGIA
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Brasil