Combination therapy with interferon and ribavirin for chronic hepatitis C infection in beta-thalassaemia major
(East. Mediterr. health j).
em Inglês
| WHOLIS
| ID: who-117699
Biblioteca responsável:
CH1.1
Treatment of chronic hepatitis C virus [HCV] infection in transfusion-dependent betathalassaemia major patients is complicated by existing hepatic siderosis and the fear of ribavirinassociated haemolysis. We evaluated the efficacy and side-effects of combination interferon-alpha [INF] and ribavirin therapy for HCV-infected thalassaemia patients. A total of 17 patients were enrolled [10 nonresponders to INF monotherapy, 7 naive to treatment, mean age 23.1 years] and they received 12 months of combination therapy. The sustained virological response rate 6 months after treatment was 58.8%. Blood transfusion requirements during treatment temporarily increased by 36.6%. Combination therapy was tolerated by, and may be useful for, HCV-infected thalassaemia major patients
Texto completo:
Disponível
Coleções:
Bases de dados de organismos internacionais
Temas:
Doenças crônicas e degenerativas
Base de dados:
WHO IRIS
Assunto principal:
Ribavirina
/
Transfusão de Sangue
/
Interferons
/
Resultado do Tratamento
/
Talassemia beta
/
Hepatite C Crônica
/
Quimioterapia Combinada
Idioma:
Inglês
Revista:
East. Mediterr. health j
Ano de publicação:
2009
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