Microservice Application Scheduling in Multi-Tiered Fog-Computing-Enabled IoT.

Fog computing extends mobile cloud computing facilities at the network edge, yielding low-latency application execution. To supplement cloud services, computationally intensive applications can be distributed on resource-constrained mobile devices by leveraging underutilized nearby resources to meet the latency and bandwidth requirements of application execution. Building upon this premise, it is necessary to investigate idle or underutilized resources that are present at the edge of the network. The utilization of a microservice architecture in IoT application development, with its increased granularity in service breakdown, provides opportunities for improved scalability, maintainability, and extensibility. In this research, the proposed schedule tackles the latency requirements of applications by identifying suitable upward migration of microservices within a multi-tiered fog computing infrastructure. This approach enables optimal utilization of network edge resources. Experimental validation is performed using the iFogSim2 simulator and the results are compared with existing baselines. The results demonstrate that compared to the edgewards approach, our proposed technique significantly improves the latency requirements of application execution, network usage, and energy consumption by 66.92%, 69.83%, and 4.16%, respectively.

An Adaptive Learning Model for Multiscale Texture Features in Polyp Classification via Computed Tomographic Colonography.

Objective: As an effective lesion heterogeneity depiction, texture information extracted from computed tomography has become increasingly important in polyp classification. However, variation and redundancy among multiple texture descriptors render a challenging task of integrating them into a general characterization. Considering these two problems, this work proposes an adaptive learning model to integrate multi-scale texture features. Methods: To mitigate feature variation, the whole feature set is geometrically split into several independent subsets that are ranked by a learning evaluation measure after preliminary classifications. To reduce feature redundancy, a bottom-up hierarchical learning framework is proposed to ensure monotonic increase of classification performance while integrating these ranked sets selectively. Two types of classifiers, traditional (random forest + support vector machine)- and convolutional neural network (CNN)-based, are employed to perform the polyp classification under the proposed framework with extended Haralick measures and gray-level co-occurrence matrix (GLCM) as inputs, respectively. Experimental results are based on a retrospective dataset of 63 polyp masses (defined as greater than 3 cm in largest diameter), including 32 adenocarcinomas and 31 benign adenomas, from adult patients undergoing first-time computed tomography colonography and who had corresponding histopathology of the detected masses. Results: We evaluate the performance of the proposed models by the area under the curve (AUC) of the receiver operating characteristic curve. The proposed models show encouraging performances of an AUC score of 0.925 with the traditional classification method and an AUC score of 0.902 with CNN. The proposed adaptive learning framework significantly outperforms nine well-established classification methods, including six traditional methods and three deep learning ones with a large margin. Conclusions: The proposed adaptive learning model can combat the challenges of feature variation through a multiscale grouping of feature inputs, and the feature redundancy through a hierarchal sorting of these feature groups. The improved classification performance against comparative models demonstrated the feasibility and utility of this adaptive learning procedure for feature integration.

Lesion Classification by Model-Based Feature Extraction: A Differential Affine Invariant Model of Soft Tissue Elasticity in CT Images.

The elasticity of soft tissues has been widely considered a characteristic property for differentiation of healthy and lesions and, therefore, motivated the development of several elasticity imaging modalities, for example, ultrasound elastography, magnetic resonance elastography, and optical coherence elastography to directly measure the tissue elasticity. This paper proposes an alternative approach of modeling the elasticity for prior knowledge-based extraction of tissue elastic characteristic features for machine learning (ML) lesion classification using computed tomography (CT) imaging modality. The model describes a dynamic non-rigid (or elastic) soft tissue deformation in differential manifold to mimic the tissues' elasticity under wave fluctuation in vivo. Based on the model, a local deformation invariant is formulated using the 1st and 2nd order derivatives of the lesion volumetric CT image and used to generate elastic feature map of the lesion volume. From the feature map, tissue elastic features are extracted and fed to ML to perform lesion classification. Two pathologically proven image datasets of colon polyps and lung nodules were used to test the modeling strategy. The outcomes reached the score of area under the curve of receiver operating characteristics of 94.2% for the polyps and 87.4% for the nodules, resulting in an average gain of 5 to 20% over several existing state-of-the-art image feature-based lesion classification methods. The gain demonstrates the importance of extracting tissue characteristic features for lesion classification, instead of extracting image features, which can include various image artifacts and may vary for different protocols in image acquisition and different imaging modalities.

Foreign Body Aspiration Mimicking an Endobronchial Neoplasm: A Case Report and Review of the Literature.

Foreign body aspiration (FBA) is infrequently encountered in the adult population, with major risk factors including advancing age, intoxication, and disorders of the central nervous system. Here, we present a case of FBA in an adult undergoing routine lung cancer screening to review imaging findings and highlight potential pitfalls for the practicing radiologist. A low-dose chest computed tomography (CT) scan was performed for lung cancer screening in a 57-year-old male with a one-month history of worsening dyspnea and cough. An endobronchial lesion was identified in the right bronchus intermedius. A follow-up 18F-fluorodeoxyglucose positron emission tomography-computed tomography (18F-FDG PET-CT) revealed hypermetabolic activity in the region of interest, raising concern for malignancy. Bronchoscopy was performed, revealing a nodular mass adjacent to a foreign body in the bronchus intermedius. Histopathologic analysis of the tissue sample revealed the presence of an aspirated foreign body with squamous metaplasia of the respiratory epithelium. Adult FBA is an uncommon clinical entity that may be incidentally observed on a screening chest CT. Relevant multimodality imaging findings are discussed here, along with a review of the accompanying pathologic changes seen with chronic airway impaction.

Leveraging Deep Learning for Designing Healthcare Analytics Heuristic for Diagnostics.

Healthcare Informatics is a phenomenon being talked about from the early 21st century in the era in which we are living. With evolution of new computing technologies huge amount of data in healthcare is produced opening several research areas. Managing the massiveness of this data is required while extracting knowledge for decision making is the main concern of today. For this task researchers are doing explorations in big data analytics, deep learning (advanced form of machine learning known as deep neural nets), predictive analytics and various other algorithms to bring innovation in healthcare. Through all these innovations happening it is not wrong to establish that disease prediction with anticipation of its cure is no longer unrealistic. First, Dengue Fever (DF) and then Covid-19 likewise are new outbreak in infectious lethal diseases and diagnosing at all stages is crucial to decrease mortality rate. In case of Diabetes, clinicians and experts are finding challenging the timely diagnosis and analyzing the chances of developing underlying diseases. In this paper, Louvain Mani-Hierarchical Fold Learning healthcare analytics, a hybrid deep learning technique is proposed for medical diagnostics and is tested and validated using real-time dataset of 104 instances of patients with dengue fever made available by Holy Family Hospital, Pakistan and 810 instances found for infectious diseases including prognosis of; Covid-19, SARS, ARDS, Pneumocystis, Streptococcus, Chlamydophila, Klebsiella, Legionella, Lipoid, etc. on GitHub. Louvain Mani-Hierarchical Fold Learning healthcare analytics showed maximum 0.952 correlations between two clusters with Spearman when applied on 240 instances extracted from comorbidities diagnostic data model derived from 15696 endocrine records of multiple visits of 100 patients identified by a unique ID. Accuracy for induced rules is evaluated by Laplace (Fig. 8) as 0.727, 0.701 and 0.203 for 41, 18 and 24 rules, respectively. Endocrine diagnostic data is made available by Shifa International Hospital, Islamabad, Pakistan. Our results show that in future this algorithm may be tested for diagnostics on healthcare big data.

Longitudinal Chest X-ray Scores and their Relations with Clinical Variables and Outcomes in COVID-19 Patients.

Background: This study evaluated the temporal characteristics of lung chest X-ray (CXR) scores in COVID-19 patients during hospitalization and how they relate to other clinical variables and outcomes (alive or dead). Methods: This is a retrospective study of COVID-19 patients. CXR scores of disease severity were analyzed for: (i) survivors (N = 224) versus non-survivors (N = 28) in the general floor group, and (ii) survivors (N = 92) versus non-survivors (N = 56) in the invasive mechanical ventilation (IMV) group. Unpaired t-tests were used to compare survivors and non-survivors and between time points. Comparison across multiple time points used repeated measures ANOVA and corrected for multiple comparisons. Results: For general-floor patients, non-survivor CXR scores were significantly worse at admission compared to those of survivors (p < 0.05), and non-survivor CXR scores deteriorated at outcome (p < 0.05) whereas survivor CXR scores did not (p > 0.05). For IMV patients, survivor and non-survivor CXR scores were similar at intubation (p > 0.05), and both improved at outcome (p < 0.05), with survivor scores showing greater improvement (p < 0.05). Hospitalization and IMV duration were not different between groups (p > 0.05). CXR scores were significantly correlated with lactate dehydrogenase, respiratory rate, D-dimer, C-reactive protein, procalcitonin, ferritin, SpO2, and lymphocyte count (p < 0.05). Conclusions: Longitudinal CXR scores have the potential to provide prognosis, guide treatment, and monitor disease progression.

Classification of Non-Functional Requirements From IoT Oriented Healthcare Requirement Document.

Internet of Things (IoT) involves a set of devices that aids in achieving a smart environment. Healthcare systems, which are IoT-oriented, provide monitoring services of patients' data and help take immediate steps in an emergency. Currently, machine learning-based techniques are adopted to ensure security and other non-functional requirements in smart health care systems. However, no attention is given to classifying the non-functional requirements from requirement documents. The manual process of classifying the non-functional requirements from documents is erroneous and laborious. Missing non-functional requirements in the Requirement Engineering (RE) phase results in IoT oriented healthcare system with compromised security and performance. In this research, an experiment is performed where non-functional requirements are classified from the IoT-oriented healthcare system's requirement document. The machine learning algorithms considered for classification are Logistic Regression (LR), Support Vector Machine (SVM), Multinomial Naive Bayes (MNB), K-Nearest Neighbors (KNN), ensemble, Random Forest (RF), and hybrid KNN rule-based machine learning (ML) algorithms. The results show that our novel hybrid KNN rule-based machine learning algorithm outperforms others by showing an average classification accuracy of 75.9% in classifying non-functional requirements from IoT-oriented healthcare requirement documents. This research is not only novel in its concept of using a machine learning approach for classification of non-functional requirements from IoT-oriented healthcare system requirement documents, but it also proposes a novel hybrid KNN-rule based machine learning algorithm for classification with better accuracy. A new dataset is also created for classification purposes, comprising requirements related to IoT-oriented healthcare systems. However, since this dataset is small and consists of only 104 requirements, this might affect the generalizability of the results of this research.

Vector textures derived from higher order derivative domains for classification of colorectal polyps.

Textures have become widely adopted as an essential tool for lesion detection and classification through analysis of the lesion heterogeneities. In this study, higher order derivative images are being employed to combat the challenge of the poor contrast across similar tissue types among certain imaging modalities. To make good use of the derivative information, a novel concept of vector texture is firstly introduced to construct and extract several types of polyp descriptors. Two widely used differential operators, i.e., the gradient operator and Hessian operator, are utilized to generate the first and second order derivative images. These derivative volumetric images are used to produce two angle-based and two vector-based (including both angle and magnitude) textures. Next, a vector-based co-occurrence matrix is proposed to extract texture features which are fed to a random forest classifier to perform polyp classifications. To evaluate the performance of our method, experiments are implemented over a private colorectal polyp dataset obtained from computed tomographic colonography. We compare our method with four existing state-of-the-art methods and find that our method can outperform those competing methods over 4%-13% evaluated by the area under the receiver operating characteristics curves.

A dynamic lesion model for differentiation of malignant and benign pathologies.

Malignant lesions have a high tendency to invade their surrounding environment compared to benign ones. This paper proposes a dynamic lesion model and explores the 2nd order derivatives at each image voxel, which reflect the rate of change of image intensity, as a quantitative measure of the tendency. The 2nd order derivatives at each image voxel are usually represented by the Hessian matrix, but it is difficult to quantify a matrix field (or image) through the lesion space as a measure of the tendency. We conjecture that the three eigenvalues contain important information of the Hessian matrix and are chosen as the surrogate representation of the Hessian matrix. By treating the three eigenvalues as a vector, called Hessian vector, which is defined in a local coordinate formed by three orthogonal Hessian eigenvectors and further adapting the gray level occurrence computing method to extract the vector texture descriptors (or measures) from the Hessian vector, a quantitative presentation for the dynamic lesion model is completed. The vector texture descriptors were applied to differentiate malignant from benign lesions from two pathologically proven datasets: colon polyps and lung nodules. The classification results not only outperform four state-of-the-art methods but also three radiologist experts.

Deep transfer learning artificial intelligence accurately stages COVID-19 lung disease severity on portable chest radiographs.

This study employed deep-learning convolutional neural networks to stage lung disease severity of Coronavirus Disease 2019 (COVID-19) infection on portable chest x-ray (CXR) with radiologist score of disease severity as ground truth. This study consisted of 131 portable CXR from 84 COVID-19 patients (51M 55.1±14.9yo; 29F 60.1±14.3yo; 4 missing information). Three expert chest radiologists scored the left and right lung separately based on the degree of opacity (0-3) and geographic extent (0-4). Deep-learning convolutional neural network (CNN) was used to predict lung disease severity scores. Data were split into 80% training and 20% testing datasets. Correlation analysis between AI-predicted versus radiologist scores were analyzed. Comparison was made with traditional and transfer learning. The average opacity score was 2.52 (range: 0-6) with a standard deviation of 0.25 (9.9%) across three readers. The average geographic extent score was 3.42 (range: 0-8) with a standard deviation of 0.57 (16.7%) across three readers. The inter-rater agreement yielded a Fleiss' Kappa of 0.45 for opacity score and 0.71 for extent score. AI-predicted scores strongly correlated with radiologist scores, with the top model yielding a correlation coefficient (R2) of 0.90 (range: 0.73-0.90 for traditional learning and 0.83-0.90 for transfer learning) and a mean absolute error of 8.5% (ranges: 17.2-21.0% and 8.5%-15.5, respectively). Transfer learning generally performed better. In conclusion, deep-learning CNN accurately stages disease severity on portable chest x-ray of COVID-19 lung infection. This approach may prove useful to stage lung disease severity, prognosticate, and predict treatment response and survival, thereby informing risk management and resource allocation.

Predicting COVID-19 Pneumonia Severity on Chest X-ray With Deep Learning.

Introduction The need to streamline patient management for coronavirus disease-19 (COVID-19) has become more pressing than ever. Chest X-rays (CXRs) provide a non-invasive (potentially bedside) tool to monitor the progression of the disease. In this study, we present a severity score prediction model for COVID-19 pneumonia for frontal chest X-ray images. Such a tool can gauge the severity of COVID-19 lung infections (and pneumonia in general) that can be used for escalation or de-escalation of care as well as monitoring treatment efficacy, especially in the ICU. Methods Images from a public COVID-19 database were scored retrospectively by three blinded experts in terms of the extent of lung involvement as well as the degree of opacity. A neural network model that was pre-trained on large (non-COVID-19) chest X-ray datasets is used to construct features for COVID-19 images which are predictive for our task. Results This study finds that training a regression model on a subset of the outputs from this pre-trained chest X-ray model predicts our geographic extent score (range 0-8) with 1.14 mean absolute error (MAE) and our lung opacity score (range 0-6) with 0.78 MAE. Conclusions These results indicate that our model's ability to gauge the severity of COVID-19 lung infections could be used for escalation or de-escalation of care as well as monitoring treatment efficacy, especially in the ICU. To enable follow up work, we make our code, labels, and data available online.

3D-GLCM CNN: A 3-Dimensional Gray-Level Co-Occurrence Matrix-Based CNN Model for Polyp Classification via CT Colonography.

Accurately classifying colorectal polyps, or differentiating malignant from benign ones, has a significant clinical impact on early detection and identifying optimal treatment of colorectal cancer. Convolution neural network (CNN) has shown great potential in recognizing different objects (e.g. human faces) from multiple slice (or color) images, a task similar to the polyp differentiation, given a large learning database. This study explores the potential of CNN learning from multiple slice (or feature) images to differentiate malignant from benign polyps from a relatively small database with pathological ground truth, including 32 malignant and 31 benign polyps represented by volumetric computed tomographic (CT) images. The feature image in this investigation is the gray-level co-occurrence matrix (GLCM). For each volumetric polyp, there are 13 GLCMs, computed from each of the 13 directions through the polyp volume. For comparison purpose, the CNN learning is also applied to the multi-slice CT images of the volumetric polyps. The comparison study is further extended to include Random Forest (RF) classification of the Haralick texture features (derived from the GLCMs). From the relatively small database, this study achieved scores of 0.91/0.93 (two-fold/leave-one-out evaluations) AUC (area under curve of the receiver operating characteristics) by using the CNN on the GLCMs, while the RF reached 0.84/0.86 AUC on the Haralick features and the CNN rendered 0.79/0.80 AUC on the multiple-slice CT images. The presented CNN learning from the GLCMs can relieve the challenge associated with relatively small database, improve the classification performance over the CNN on the raw CT images and the RF on the Haralick features, and have the potential to perform the clinical task of differentiating malignant from benign polyps with pathological ground truth.

Multi-scale characterizations of colon polyps via computed tomographic colonography.

Texture features have played an essential role in the field of medical imaging for computer-aided diagnosis. The gray-level co-occurrence matrix (GLCM)-based texture descriptor has emerged to become one of the most successful feature sets for these applications. This study aims to increase the potential of these features by introducing multi-scale analysis into the construction of GLCM texture descriptor. In this study, we first introduce a new parameter - stride, to explore the definition of GLCM. Then we propose three multi-scaling GLCM models according to its three parameters, (1) learning model by multiple displacements, (2) learning model by multiple strides (LMS), and (3) learning model by multiple angles. These models increase the texture information by introducing more texture patterns and mitigate direction sparsity and dense sampling problems presented in the traditional Haralick model. To further analyze the three parameters, we test the three models by performing classification on a dataset of 63 large polyp masses obtained from computed tomography colonoscopy consisting of 32 adenocarcinomas and 31 benign adenomas. Finally, the proposed methods are compared to several typical GLCM-texture descriptors and one deep learning model. LMS obtains the highest performance and enhances the prediction power to 0.9450 with standard deviation 0.0285 by area under the curve of receiver operating characteristics score which is a significant improvement.

Multilayer feature selection method for polyp classification via computed tomographic colonography.

Polyp classification is a feature selection and clustering process. Picking the most effective features from multiple polyp descriptors without redundant information is a great challenge in this procedure. We propose a multilayer feature selection method to construct an optimized descriptor for polyp classification with a feature-grouping strategy in a hierarchical framework. First, the proposed method makes good use of image metrics, such as intensity, gradient, and curvature, to divide their corresponding polyp descriptors into several feature groups, which are the preliminary units of this method. Then each preliminary unit generates two ranked descriptors, i.e., their optimized variable groups (OVGs) and preliminary classification measurements. Next, a feature dividing-merging (FDM) algorithm is designed to perform feature merging operation hierarchically and iteratively. Unlike traditional feature selection methods, the proposed FDM algorithm includes two steps for feature dividing and feature merging. At each layer, feature dividing selects the OVG with the highest area under the receiver operating characteristic curve (AUC) as the baseline while other descriptors are treated as its complements. In the fusion step, the FDM merges some variables with gains into the baseline from the complementary descriptors iteratively on every layer until the final descriptor is obtained. This proposed model (including the forward step algorithm and the FDM algorithm) is a greedy method that guarantees clustering monotonicity of all OVGs from the bottom to the top layer. In our experiments, all the selected results from each layer are reported by both graphical illustration and data analysis. Performance of the proposed method is compared to five existing classification methods by a polyp database of 63 samples with pathological reports. The experimental results show that our proposed method outperforms other methods by 4% to 23% gains in terms of AUC scores.

Invariant domain watermarking using heaviside function of order alpha and fractional Gaussian field.

Digital image watermarking is an important technique for the authentication of multimedia content and copyright protection. Conventional digital image watermarking techniques are often vulnerable to geometric distortions such as Rotation, Scaling, and Translation (RST). These distortions desynchronize the watermark information embedded in an image and thus disable watermark detection. To solve this problem, we propose an RST invariant domain watermarking technique based on fractional calculus. We have constructed a domain using Heaviside function of order alpha (HFOA). The HFOA models the signal as a polynomial for watermark embedding. The watermark is embedded in all the coefficients of the image. We have also constructed a fractional variance formula using fractional Gaussian field. A cross correlation method based on the fractional Gaussian field is used for watermark detection. Furthermore the proposed method enables blind watermark detection where the original image is not required during the watermark detection thereby making it more practical than non-blind watermarking techniques. Experimental results confirmed that the proposed technique has a high level of robustness.