Detalhe da pesquisa
1.
Discovery, synthesis and exploration of N-benzylsulfonyl-2-phenylazepanes as inhibitors of Bim expression in a mouse embryonic fibroblast model.
Bioorg Chem
; 120: 105635, 2022 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-35124512
2.
Synthesis and structure-activity relationship studies of 2,4-thiazolidinediones and analogous heterocycles as inhibitors of dihydrodipicolinate synthase.
Bioorg Med Chem
; 52: 116518, 2021 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34826680
3.
Elaboration of a benzofuran scaffold and evaluation of binding affinity and inhibition of Escherichia coli DsbA: A fragment-based drug design approach to novel antivirulence compounds.
Bioorg Med Chem
; 45: 116315, 2021 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34364222
4.
The Fragment-Based Development of a Benzofuran Hit as a New Class of Escherichia coli DsbA Inhibitors.
Molecules
; 24(20)2019 Oct 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-31635355
5.
Halocarbons as hydrogen bond acceptors: a spectroscopic study of haloethylbenzenes (PhCH2CH2X, X = F, Cl, Br) and their hydrate clusters.
Phys Chem Chem Phys
; 20(12): 8218-8227, 2018 Mar 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-29528053
6.
Synthesis of novel 1,2,5-oxadiazoles and evaluation of action against Acinetobacter baumannii.
Bioorg Med Chem
; 25(24): 6267-6272, 2017 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29032931
7.
Antimalarial activity of novel 4-cyano-3-methylisoquinoline inhibitors against Plasmodium falciparum: design, synthesis and biological evaluation.
Org Biomol Chem
; 14(20): 4617-39, 2016 May 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-27105169
8.
Efficacy of peptide nucleic acid and selected conjugates against specific cellular pathologies of amyotrophic lateral sclerosis.
Bioorg Med Chem
; 24(7): 1520-7, 2016 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26935939
9.
Exploration of 3-methylisoquinoline-4-carbonitriles as protein kinase A inhibitors of Plasmodium falciparum.
Bioorg Med Chem
; 24(11): 2389-96, 2016 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27112453
10.
Synthesis and biological evaluation of 2-anilino-4-substituted-7H-pyrrolopyrimidines as PDK1 inhibitors.
Bioorg Med Chem
; 22(15): 3879-86, 2014 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25012568
11.
Synthesis and biological evaluation of substituted 3-anilino-quinolin-2(1H)-ones as PDK1 inhibitors.
Bioorg Med Chem
; 22(14): 3781-90, 2014 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24856302
12.
Synthesis and effects of conjugated tocopherol analogues on peptide nucleic acid hybridisation.
Org Biomol Chem
; 11(39): 6744-50, 2013 Oct 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-23995261
13.
Enhancing allosteric inhibition of dihydrodipicolinate synthase through the design and synthesis of novel dimeric compounds.
RSC Med Chem
; 14(9): 1698-1703, 2023 Sep 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-37731698
14.
PI 3-kinase p110beta: a new target for antithrombotic therapy.
Nat Med
; 11(5): 507-14, 2005 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-15834429
15.
A dual-target herbicidal inhibitor of lysine biosynthesis.
Elife
; 112022 06 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-35723913
16.
A novel small molecule inhibitor of human Drp1.
Sci Rep
; 12(1): 21531, 2022 12 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-36513726
17.
Towards novel herbicide modes of action by inhibiting lysine biosynthesis in plants.
Elife
; 102021 07 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-34313586
18.
A 4-cyano-3-methylisoquinoline inhibitor of Plasmodium falciparum growth targets the sodium efflux pump PfATP4.
Sci Rep
; 9(1): 10292, 2019 07 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-31311978
19.
Molecular evolution of an oligomeric biocatalyst functioning in lysine biosynthesis.
Biophys Rev
; 10(2): 153-162, 2018 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-29204887
20.
Recent progress towards an effective treatment of amyotrophic lateral sclerosis using the SOD1 mouse model in a preclinical setting.
Eur J Med Chem
; 121: 918-925, 2016 Oct 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-27012524