Detalhe da pesquisa
1.
In Vivo and In Vitro Characterization of Close Analogs of Compound KA-11, a New Antiseizure Drug Candidate.
Int J Mol Sci
; 24(9)2023 May 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37176010
2.
Asymmetric synthesis and in vivo/in vitro characterization of new hybrid anticonvulsants derived from (2,5-dioxopyrrolidin-1-yl)phenylacetamides.
Bioorg Chem
; 109: 104751, 2021 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33647745
3.
Synthesis, anticonvulsant, and antinociceptive activity of new 3-(3-methyl-2,5-dioxo-3-phenylpyrrolidin-1-yl)propanamides and 3-phenyl-butanamides.
Arch Pharm (Weinheim)
; 354(1): e2000225, 2021 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-32939789
4.
Preclinical Assessment of a New Hybrid Compound C11 Efficacy on Neurogenesis and Cognitive Functions after Pilocarpine Induced Status Epilepticus in Mice.
Int J Mol Sci
; 22(6)2021 Mar 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-33810180
5.
Identification of New Compounds with Anticonvulsant and Antinociceptive Properties in a Group of 3-substituted (2,5-dioxo-pyrrolidin-1-yl)(phenyl)-Acetamides.
Int J Mol Sci
; 22(23)2021 Dec 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-34884898
6.
C-11, a New Antiepileptic Drug Candidate: Evaluation of the Physicochemical Properties and Impact on the Protective Action of Selected Antiepileptic Drugs in the Mouse Maximal Electroshock-Induced Seizure Model.
Molecules
; 26(11)2021 May 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-34074008
7.
KA-104, a new multitargeted anticonvulsant with potent antinociceptive activity in preclinical models.
Epilepsia
; 61(10): 2119-2128, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32929733
8.
The Search for New Anticonvulsants in a Group of (2,5-Dioxopyrrolidin-1-yl)(phenyl)Acetamides with Hybrid Structure-Synthesis and In Vivo/In Vitro Studies.
Int J Mol Sci
; 21(22)2020 Nov 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-33233618
9.
New hybrid molecules with anticonvulsant and antinociceptive activity derived from 3-methyl- or 3,3-dimethyl-1-[1-oxo-1-(4-phenylpiperazin-1-yl)propan-2-yl]pyrrolidine-2,5-diones.
Bioorg Med Chem
; 24(4): 606-18, 2016 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26746343
10.
A comprehensive assessment of palmatine as anticonvulsant agent - In vivo and in silico studies.
Biomed Pharmacother
; 172: 116234, 2024 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-38325264
11.
Novel Alaninamide Derivatives with Drug-like Potential for Development as Antiseizure and Antinociceptive TherapiesâIn Vitro and In Vivo Characterization.
ACS Chem Neurosci
; 2024 May 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-38741575
12.
New Phenylglycinamide Derivatives with Hybrid Structure as Candidates for New Broad-Spectrum Anticonvulsants.
Cells
; 11(12)2022 06 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35740990
13.
Discovery of (R)-N-Benzyl-2-(2,5-dioxopyrrolidin-1-yl)propanamide [(R)-AS-1], a Novel Orally Bioavailable EAAT2 Modulator with Drug-like Properties and Potent Antiseizure Activity In Vivo.
J Med Chem
; 65(17): 11703-11725, 2022 09 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35984707
14.
Multifunctional Arylsulfone and Arylsulfonamide-Based Ligands with Prominent Mood-Modulating Activity and Benign Safety Profile, Targeting Neuropsychiatric Symptoms of Dementia.
J Med Chem
; 64(17): 12603-12629, 2021 09 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34436892
15.
Multitargeted Compounds Derived from (2,5-Dioxopyrrolidin-1-yl)(phenyl)-Acetamides as Candidates for Effective Anticonvulsant and Antinociceptive Agents.
ACS Chem Neurosci
; 11(13): 1996-2008, 2020 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32479058
16.
Evaluation of the impact of compound C11 a new anticonvulsant candidate on cognitive functions and hippocampal neurogenesis in mouse brain.
Neuropharmacology
; 163: 107849, 2020 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-31706991
17.
N-Benzyl-(2,5-dioxopyrrolidin-1-yl)propanamide (AS-1) with Hybrid Structure as a Candidate for a Broad-Spectrum Antiepileptic Drug.
Neurotherapeutics
; 17(1): 309-328, 2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31486023
18.
Chirality as an Important Factor for the Development of New Antiepileptic Drugs.
ChemMedChem
; 14(20): 1744-1761, 2019 10 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-31476107
19.
KA-11, a Novel Pyrrolidine-2,5-dione Derived Broad-Spectrum Anticonvulsant: Its Antiepileptogenic, Antinociceptive Properties and in Vitro Characterization.
ACS Chem Neurosci
; 10(1): 636-648, 2019 01 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-30247871
20.
Evaluation of anticonvulsant and analgesic activity of new hybrid compounds derived from N-phenyl-2-(2,5-dioxopyrrolidin-1-yl)-propanamides and -butanamides.
Epilepsy Res
; 143: 11-19, 2018 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-29631129