Prevalence and abundance of Staphylococcus aureus in the middle meatus of patients with chronic rhinosinusitis, nasal polyps, and asthma.

BACKGROUND: Chronic rhinosinusitis (CRS) is an idiosyncratic and multifactorial disease process. Bacteria play a role in some patients, by infection or stimulation of inflammation. Staphylococcus aureus (SA) appears to be implicated in a number of infectious and inflammatory mechanisms, and may be particularly relevant in CRS patients with nasal polyps and asthma. METHODS: Middle meatus swabs from control and CRS patients collected during endoscopic sinus surgery were analyzed by quantitative polymerase chain reaction (QPCR). Total bacterial count, SA prevalence, and SA abundance were examined with respect to patient demographics and disease characteristics. RESULTS: Total bacteria, as measured by QPCR, was not statistically different between controls, CRS without nasal polyps (CRSsNP), CRS with nasal polyps (CRSwNP), or CRS with asthma groups (p < 0.09). Total bacterial counts did not correlate with disease severity as measured by Lund-Mackay computed tomography (CT) scores (p = 0.65). The prevalence of SA was similar between groups (15-25%); however, the abundance increased in CRS patients with allergic rhinitis, nasal polyps, and asthma. CONCLUSION: The paranasal sinuses are not sterile. SA is implicated in a subset of CRS patients with nasal polyps and/or asthma. Further study is required to predict this subset of patients, and to define the mechanisms of SA pathogenesis.

Factors associated with computed tomography status in patients presenting with a history of chronic rhinosinusitis.

BACKGROUND: The diagnosis of chronic rhinosinusitis (CRS) is based upon symptomatic criteria and objective measures. However, patients suspected to have CRS based on a positive history but negative endoscopies remain a diagnostic challenge. We investigated the utility of point of care computed tomography (POC-CT) in resolving this issue. METHODS: The study group consisted of a simple random sample of 100 patients presenting with active CRS symptoms and negative endoscopies who underwent POC-CT at initial presentation. Presenting symptoms and comorbidities were correlated with CT scan results (positive/negative) using univariate and multivariate logistic regression models. RESULTS: POC-CT was considered positive in 49% of patients. Univariate analysis revealed that patients complaining nasal obstruction were significantly more likely to have a positive scan (odds ratio [OR], 2.74; p = 0.047), while those with postnasal drip (OR, 0.44; p = 0.047) or cough (OR, 0.17; p = 0.03) were less likely to have positive scan results. In the multivariate model, these trends persisted without reaching statistical significance. Under univariate analysis, patients who were prescribed antibiotics, oral steroids, or nasal steroids at this initial visit were more likely to have had a positive CT. These trends also persisted in the multivariate model, with significance observed for the association between antibiotic prescription and a positive scan (p = 0.001). CONCLUSION: Less than 50% of patients with active CRS symptoms had radiographic manifestations of sinus disease. Other etiologies must be considered higher in the differential for those presenting primarily with complaints referable to the throat. POC-CT averted unnecessary antibiotics in these patients.