Detalhe da pesquisa
1.
Efficacy and Safety of Abrilumab in a Randomized, Placebo-Controlled Trial for Moderate-to-Severe Ulcerative Colitis.
Gastroenterology
; 156(4): 946-957.e18, 2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30472236
2.
Evaluation of near infrared fluorescent labeling of monoclonal antibodies as a tool for tissue distribution.
Drug Metab Dispos
; 42(11): 1906-13, 2014 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-25209366
3.
Population Pharmacokinetic Modeling and Exposure-Efficacy and Body Weight-Response Analyses for Tezepelumab in Patients With Severe, Uncontrolled Asthma.
J Clin Pharmacol
; 2024 Apr 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-38632826
4.
Investigation of the role of FcγR and FcRn in mAb distribution to the brain.
Mol Pharm
; 10(5): 1505-13, 2013 May 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-22838637
5.
Pharmacokinetics and Pharmacokinetic/Pharmacodynamic Properties of Rozibafusp Alfa, a Bispecific Inhibitor of BAFF and ICOSL: Analyses of Phase I Clinical Trials.
Clin Pharmacol Ther
; 114(2): 371-380, 2023 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37150935
6.
High-throughput method development for sensitive, accurate, and reproducible quantification of therapeutic monoclonal antibodies in tissues using orthogonal array optimization and nano liquid chromatography/selected reaction monitoring mass spectrometry.
Anal Chem
; 84(10): 4373-82, 2012 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22519810
7.
Application of PBPK modeling to predict monoclonal antibody disposition in plasma and tissues in mouse models of human colorectal cancer.
J Pharmacokinet Pharmacodyn
; 39(6): 683-710, 2012 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-23184417
8.
Development and Evaluation of Competitive Inhibitors of Trastuzumab-HER2 Binding to Bypass the Binding-Site Barrier.
Front Pharmacol
; 13: 837744, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35250584
9.
Safety and Biological Activity of Rozibafusp alfa, a Bispecific Inhibitor of Inducible Costimulator Ligand and B Cell Activating Factor, in Patients With Rheumatoid Arthritis: Results of a Phase 1b, Randomized, Double-Blind, Placebo-Controlled, Multiple Ascending Dose Study.
ACR Open Rheumatol
; 4(10): 903-911, 2022 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-35899378
10.
Tezepelumab Pharmacokinetics, Safety, and Tolerability After Administration via Vial-and-syringe, Accessorized Prefilled Syringe, or Autoinjector: A Randomized Trial in Healthy Volunteers.
Clin Ther
; 43(1): 142-155.e5, 2021 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33380362
11.
AKR-001, an Fc-FGF21 Analog, Showed Sustained Pharmacodynamic Effects on Insulin Sensitivity and Lipid Metabolism in Type 2 Diabetes Patients.
Cell Rep Med
; 1(4): 100057, 2020 07 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-33205064
12.
Assessments of antibody biodistribution.
J Clin Pharmacol
; 55 Suppl 3: S29-38, 2015 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-25707961
13.
Antibody engineering and therapeutics, The Annual Meeting of the Antibody Society: December 8-12, 2013, Huntington Beach, CA.
MAbs
; 6(3): 577-618, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24589717
14.
Application of knockout mouse models to investigate the influence of FcγR on the pharmacokinetics and anti-platelet effects of MWReg30, a monoclonal anti-GPIIb antibody.
Int J Pharm
; 444(1-2): 185-92, 2013 Feb 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-23370434
15.
Application of knockout mouse models to investigate the influence of FcγR on the tissue distribution and elimination of 8C2, a murine IgG1 monoclonal antibody.
Int J Pharm
; 439(1-2): 8-16, 2012 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23018115
16.
Pharmacokinetic mAb-mAb interaction: anti-VEGF mAb decreases the distribution of anti-CEA mAb into colorectal tumor xenografts.
AAPS J
; 14(3): 445-55, 2012 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-22528507