Detalhe da pesquisa
1.
Nitric Oxide Signaling Strengthens Inhibitory Synapses of Cerebellar Molecular Layer Interneurons through a GABARAP-Dependent Mechanism.
J Neurosci
; 40(17): 3348-3359, 2020 04 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-32169968
2.
Drug-Induced Seizures: Considerations for Underlying Molecular Mechanisms.
Int J Toxicol
; 40(5): 403-412, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34514888
3.
Confounders and Pharmacological Characterization When Using the QT, JTp, and Tpe Intervals in Beagle Dogs.
Int J Toxicol
; 39(6): 530-541, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-33063577
4.
α6-Containing GABAA Receptors Are the Principal Mediators of Inhibitory Synapse Strengthening by Insulin in Cerebellar Granule Cells.
J Neurosci
; 35(26): 9676-88, 2015 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26134650
5.
Crosslinking the ligand-binding domain dimer interface locks kainate receptors out of the main open state.
J Physiol
; 591(16): 3873-85, 2013 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23713029
6.
The utilization of advance telemetry to investigate critical physiological parameters including electroencephalography in cynomolgus macaques following aerosol challenge with eastern equine encephalitis virus.
PLoS Negl Trop Dis
; 15(6): e0009424, 2021 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-34138849
7.
The application of electrophysiological methods to characterize AMPA receptors in dissociated adult rat and non-human primate cerebellar neurons for use in neuronal safety pharmacology assessments of the central nervous system.
J Pharmacol Toxicol Methods
; 105: 106883, 2020 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-32461084
8.
Characterization of a partial-body irradiation model with oral cavity shielding in nonhuman primates.
Int J Radiat Biol
; 96(1): 100-111, 2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29447591
9.
Unraveling the mechanism and the risk behind seizure liability of lead compounds in a neuroscience project.
J Pharmacol Toxicol Methods
; 104: 106874, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32446729
10.
Reprint of "EEG: Characteristics of drug-induced seizures in rats, dogs and non-human primates".
J Pharmacol Toxicol Methods
; 99: 106611, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31351950
11.
EEG: Characteristics of drug-induced seizures in rats, dogs and non-human primates.
J Pharmacol Toxicol Methods
; 97: 52-58, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-30922951
12.
Incidence of spontaneous arrhythmias in freely moving healthy untreated Sprague-Dawley rats.
J Pharmacol Toxicol Methods
; 99: 106589, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31154034
13.
Seizure liability assessments using the hippocampal tissue slice: Comparison of non-clinical species.
J Pharmacol Toxicol Methods
; 93: 59-68, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-29155282
14.
Safety pharmacology methods and models in an evolving regulatory environment.
J Pharmacol Toxicol Methods
; 87: 1-6, 2017 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-28461240
15.
Cardiac contractility: Correction strategies applied to telemetry data from a HESI-sponsored consortium.
J Pharmacol Toxicol Methods
; 87: 38-47, 2017 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-28434968
16.
The emerging role of in vitro electrophysiological methods in CNS safety pharmacology.
J Pharmacol Toxicol Methods
; 81: 47-59, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27058269
17.
Recalibration of nonclinical safety pharmacology assessment to anticipate evolving regulatory expectations.
J Pharmacol Toxicol Methods
; 81: 1-8, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27343819
18.
Functional neurotoxicity evaluation of noribogaine using video-EEG in cynomolgus monkeys.
J Pharmacol Toxicol Methods
; 81: 306-12, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27126304
19.
Mitochondrial reactive oxygen species regulate the strength of inhibitory GABA-mediated synaptic transmission.
Nat Commun
; 5: 3168, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24430741
20.
Nematode cys-loop GABA receptors: biological function, pharmacology and sites of action for anthelmintics.
Invert Neurosci
; 12(1): 3-12, 2012 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-22430311