RESUMO
The purpose of this study was to show how the difference in structure affects the mechanical properties of bone and if BUA or fractal analysis is able to detect these changes in mechanical properties. A total of 38 cancellous bone cubes were obtained from seven bovine tibiae (32 specimens) and one human tibia (6 specimens). BUA was measured in the superior/inferior (SI), medial/lateral (ML), and anterior/posterior (AP) directions for each specimen. The fractal dimension was estimated by using the continuous alternating sequential filter (CASF) pyramid approach to handle fractal dimension estimation of small images. Nondestructive compressive tests were also performed in the three orthogonal directions for each sample. The correlations between BUA and density were statistically significant for all three directions. The correlation between BUA and elastic modulus varied depending on the direction in which the two parameters were measured. The best correlation was in the AP directions (r = 0.75, p < 0.0001), followed by the ML direction (r = 0.52, p = 0.0006), and finally the SI direction (r = 0.18, p = 0.28). The only significant correlation between fractal dimension and density was in the SI direction (r = 0.39, p = 0.015). There was significant correlation between fractal dimension and elastic modulus in all three directions, but the direction that exhibited the best correlation was the SI direction (r = 0.61, p < 0.0001). The correlation coefficients for the AP and ML directions were 0.45 (p = 0.0046) and 0.34 (p = 0.0377), respectively. A multivariate model, carried out to predict the elastic modulus from the BUA or fractal dimension including density, demonstrated that the correlation coefficient significantly increased in all three directions for BUA and fractal dimension. After adjustment for density, significant relationships between elastic modulus and BUA or fractal dimension were still found (p < 0.05).
Assuntos
Densidade Óssea , Osso e Ossos/diagnóstico por imagem , Fractais , Animais , Fenômenos Biomecânicos , Engenharia Biomédica , Fenômenos Biofísicos , Biofísica , Osso e Ossos/fisiologia , Bovinos , Estudos de Avaliação como Assunto , Humanos , UltrassonografiaRESUMO
Although rhabdomyosarcoma (RMS) has a predilection for the head and neck region its occurrence in the tongue is uncommon. We report 2 cases of RMS of the tongue, 1 paediatric and 1 adult patient. The child who had RMS of the alveolar type involving anterior two-thirds of the tongue was treated with surgery and chemotherapy and is disease-free at 84 months of follow-up. The adult patient had locally extensive embryonal RMS of posterior third of the tongue, received chemotherapy and radiotherapy but died with progressive disease at 24 months of follow-up.
Assuntos
Rabdomiossarcoma Alveolar/patologia , Rabdomiossarcoma Embrionário/patologia , Neoplasias da Língua/patologia , Adulto , Pré-Escolar , Terapia Combinada , Evolução Fatal , Humanos , Masculino , Rabdomiossarcoma Alveolar/terapia , Rabdomiossarcoma Embrionário/terapia , Neoplasias da Língua/terapiaRESUMO
Isolated central nervous metastasis is rare in patients with Ewing's sarcoma. Here we report two cases with CNS metastasis as the sole manifestation of relapse with a brief review of the literature.
Assuntos
Neoplasias Encefálicas/secundário , Neoplasias Epidurais/secundário , Sarcoma de Ewing/secundário , Adolescente , Humanos , MasculinoRESUMO
Design of Drug administration strategies for cancer chemotherapy is formulated as an optimization problem by considering both the healthy (normal) and tumor cell kinetics. The optimization problem is solved by using concepts of exponential stabilization and an algorithm for the solution of the above problem is presented.
Assuntos
Antineoplásicos/administração & dosagem , Neoplasias/tratamento farmacológico , Células da Medula Óssea , Divisão Celular , Computadores , Humanos , Cinética , Matemática , Modelos Biológicos , Neoplasias/patologiaAssuntos
Coccidiose/diagnóstico , Diarreia/parasitologia , Eucoccidiida/isolamento & purificação , Leucemia Mieloide Aguda/complicações , Adulto , Animais , Antibacterianos/uso terapêutico , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Coccidiose/complicações , Coccidiose/tratamento farmacológico , Seguimentos , Humanos , Índia , Leucemia Mieloide Aguda/diagnóstico , Leucemia Mieloide Aguda/tratamento farmacológico , Masculino , Resultado do TratamentoAssuntos
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Carcinoma Pulmonar de Células não Pequenas/parasitologia , Hospedeiro Imunocomprometido , Neoplasias Pulmonares/parasitologia , Strongyloides stercoralis , Estrongiloidíase/etiologia , Animais , Carcinoma Pulmonar de Células não Pequenas/tratamento farmacológico , Carcinoma Pulmonar de Células não Pequenas/imunologia , Diagnóstico Diferencial , Evolução Fatal , Humanos , Neoplasias Pulmonares/tratamento farmacológico , Neoplasias Pulmonares/imunologia , Masculino , Pessoa de Meia-Idade , Estrongiloidíase/imunologia , Estrongiloidíase/patologiaRESUMO
Isolated central nervous metastasis is rare in patients with Ewing's sarcoma. Here we report two cases with CNS metastasis as the sole manifestation of relapse with a brief review of the literature.