Detalhe da pesquisa
1.
Early identification of promiscuous attributes of aldose reductase inhibitors using a DMSO-perturbation assay.
Bioorg Med Chem Lett
; 30(2): 126815, 2020 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31744675
2.
Strategy for Designing Selective Lysosomal Acid α-Glucosidase Inhibitors: Binding Orientation and Influence on Selectivity.
Molecules
; 25(12)2020 Jun 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-32575625
3.
Ginnalin B induces differentiation markers and modulates the proliferation/differentiation balance via the upregulation of NOTCH1 in human epidermal keratinocytes.
Bioorg Med Chem
; 27(11): 2172-2180, 2019 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31005366
4.
Design of a New α-1-C-Alkyl-DAB Derivative Acting as a Pharmacological Chaperone for ß-Glucocerebrosidase Using Ligand Docking and Molecular Dynamics Simulation.
Molecules
; 23(10)2018 Oct 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-30340368
5.
Multivalency To Inhibit and Discriminate Hexosaminidases.
Chemistry
; 23(38): 9022-9025, 2017 Jul 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-28548311
6.
Discovery of hyaluronidase inhibitors from natural products and their mechanistic characterization under DMSO-perturbed assay conditions.
Bioorg Med Chem Lett
; 27(7): 1620-1623, 2017 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28202328
7.
In silico analyses of essential interactions of iminosugars with the Hex A active site and evaluation of their pharmacological chaperone effects for Tay-Sachs disease.
Org Biomol Chem
; 15(44): 9297-9304, 2017 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28959811
8.
Strategy for designing selective α-l-rhamnosidase inhibitors: Synthesis and biological evaluation of l-DMDP cyclic isothioureas.
Bioorg Med Chem
; 25(1): 107-115, 2017 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27789075
9.
Interpreting the behavior of concentration-response curves of hyaluronidase inhibitors under DMSO-perturbed assay conditions.
Bioorg Med Chem Lett
; 26(13): 3153-3157, 2016 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27165854
10.
Synthesis of new tricyclic thiolactams as potent antitumor agent for pancreatic cancer.
Bioorg Med Chem Lett
; 26(11): 2577-9, 2016 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27117432
11.
Docking study and biological evaluation of pyrrolidine-based iminosugars as pharmacological chaperones for Gaucher disease.
Org Biomol Chem
; 14(3): 1039-48, 2016 Jan 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-26633162
12.
Fluorinated and Conformationally Fixed Derivatives of L-HomoDMDP: Synthesis and Glycosidase Inhibition.
J Org Chem
; 80(10): 5151-8, 2015 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25909763
13.
Design and Synthesis of Labystegines, Hybrid Iminosugars from LAB and Calystegine, as Inhibitors of Intestinal α-Glucosidases: Binding Conformation and Interaction for ntSI.
J Org Chem
; 80(9): 4501-15, 2015 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25843107
14.
3-Fluoroazetidinecarboxylic Acids and trans,trans-3,4-Difluoroproline as Peptide Scaffolds: Inhibition of Pancreatic Cancer Cell Growth by a Fluoroazetidine Iminosugar.
J Org Chem
; 80(9): 4244-58, 2015 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25859886
15.
Nine of 16 stereoisomeric polyhydroxylated proline amides are potent ß-N-acetylhexosaminidase inhibitors.
J Org Chem
; 79(8): 3398-409, 2014 Apr 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-24641544
16.
Synthesis and biological evaluation of α-1-C-4'-arylbutyl-L-arabinoiminofuranoses, a new class of α-glucosidase inhibitors.
Bioorg Med Chem Lett
; 24(15): 3298-301, 2014 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24973028
17.
Synthesis of the enantiomers of XYLNAc and LYXNAc: comparison of ß-N-acetylhexosaminidase inhibition by the 8 stereoisomers of 2-N-acetylamino-1,2,4-trideoxy-1,4-iminopentitols.
Org Biomol Chem
; 12(23): 3932-43, 2014 Jun 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-24802185
18.
Docking and SAR studies of calystegines: binding orientation and influence on pharmacological chaperone effects for Gaucher's disease.
Bioorg Med Chem
; 22(8): 2435-41, 2014 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24657053
19.
General synthesis of sugar-derived azepane nitrones: precursors of azepane iminosugars.
J Org Chem
; 78(7): 3208-21, 2013 Apr 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-23458237
20.
Synthesis of eight stereoisomers of pochonicine: nanomolar inhibition of ß-N-acetylhexosaminidases.
J Org Chem
; 78(20): 10298-309, 2013 Oct 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-24032658