Detalhe da pesquisa
1.
Bax crystal structures reveal how BH3 domains activate Bax and nucleate its oligomerization to induce apoptosis.
Cell
; 152(3): 519-31, 2013 Jan 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-23374347
2.
Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy.
Nat Rev Mol Cell Biol
; 15(1): 49-63, 2014 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-24355989
3.
Acquired mutations in BAX confer resistance to BH3-mimetic therapy in acute myeloid leukemia.
Blood
; 141(6): 634-644, 2023 02 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-36219880
4.
Clonal hematopoiesis, myeloid disorders and BAX-mutated myelopoiesis in patients receiving venetoclax for CLL.
Blood
; 139(8): 1198-1207, 2022 02 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-34469514
5.
Apoptosis-promoted tumorigenesis: gamma-irradiation-induced thymic lymphomagenesis requires Puma-driven leukocyte death.
Genes Dev
; 24(15): 1608-13, 2010 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20679396
6.
Bak activation for apoptosis involves oligomerization of dimers via their alpha6 helices.
Mol Cell
; 36(4): 696-703, 2009 Nov 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-19941828
7.
Enhanced stability of Mcl1, a prosurvival Bcl2 relative, blunts stress-induced apoptosis, causes male sterility, and promotes tumorigenesis.
Proc Natl Acad Sci U S A
; 111(1): 261-6, 2014 Jan 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-24363325
8.
Apoptotic pore formation is associated with in-plane insertion of Bak or Bax central helices into the mitochondrial outer membrane.
Proc Natl Acad Sci U S A
; 111(39): E4076-85, 2014 Sep 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-25228770
9.
To trigger apoptosis, Bak exposes its BH3 domain and homodimerizes via BH3:groove interactions.
Mol Cell
; 30(3): 369-80, 2008 May 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-18471982
10.
Deciphering the rules of programmed cell death to improve therapy of cancer and other diseases.
EMBO J
; 30(18): 3667-83, 2011 Aug 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-21863020
11.
Structure-guided design of a selective BCL-X(L) inhibitor.
Nat Chem Biol
; 9(6): 390-7, 2013 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-23603658
12.
NMR studies of interactions between Bax and BH3 domain-containing peptides in the absence and presence of CHAPS.
Arch Biochem Biophys
; 545: 33-43, 2014 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24434006
13.
The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.
Cancer Cell
; 10(5): 389-99, 2006 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-17097561
14.
Mis-expression of GATA6 re-programs cell fate during early hematopoiesis.
Cell Rep
; 43(5): 114159, 2024 Apr 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-38676923
15.
Endogenous Bcl-xL is essential for Myc-driven lymphomagenesis in mice.
Blood
; 118(24): 6380-6, 2011 Dec 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-21998213
16.
Killing cancer cells by flipping the Bcl-2/Bax switch.
Cancer Cell
; 8(1): 5-6, 2005 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-16023593
17.
Key roles of BIM-driven apoptosis in epithelial tumors and rational chemotherapy.
Cancer Cell
; 7(3): 227-38, 2005 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-15766661
18.
The Bcl2 family: regulators of the cellular life-or-death switch.
Nat Rev Cancer
; 2(9): 647-56, 2002 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-12209154
19.
Donald Metcalf: The father of modern hematology.
Proc Natl Acad Sci U S A
; 112(9): 2628-9, 2015 Mar 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-25646425
20.
Life in the balance: how BH3-only proteins induce apoptosis.
Curr Opin Cell Biol
; 17(6): 617-25, 2005 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-16243507