Detalhe da pesquisa
1.
Chaperone-directed ribosome repair after oxidative damage.
Mol Cell
; 83(9): 1527-1537.e5, 2023 05 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-37086725
2.
Programming inactive RNA-binding small molecules into bioactive degraders.
Nature
; 618(7963): 169-179, 2023 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-37225982
3.
Decreasing the intrinsically disordered protein α-synuclein levels by targeting its structured mRNA with a ribonuclease-targeting chimera.
Proc Natl Acad Sci U S A
; 121(2): e2306682120, 2024 Jan 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-38181056
4.
DNA-encoded library versus RNA-encoded library selection enables design of an oncogenic noncoding RNA inhibitor.
Proc Natl Acad Sci U S A
; 119(6)2022 02 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35110406
5.
Chemoproteomic Profiling Maps Zinc-Dependent Cysteine Reactivity.
Chem Res Toxicol
; 37(4): 620-632, 2024 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38484110
6.
Optical Control of Proteasomal Protein Degradation with a Photoswitchable Lipopeptide.
Angew Chem Int Ed Engl
; 63(8): e202314791, 2024 Feb 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-38109686
7.
Small-molecule targeted recruitment of a nuclease to cleave an oncogenic RNA in a mouse model of metastatic cancer.
Proc Natl Acad Sci U S A
; 117(5): 2406-2411, 2020 02 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-31964809
8.
Translation of the intrinsically disordered protein α-synuclein is inhibited by a small molecule targeting its structured mRNA.
Proc Natl Acad Sci U S A
; 117(3): 1457-1467, 2020 01 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-31900363
9.
DNA-Encoded Library Screening To Inform Design of a Ribonuclease Targeting Chimera (RiboTAC).
J Am Chem Soc
; 144(46): 21096-21102, 2022 11 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-36342850
10.
Transcriptome-Wide Mapping of Small-Molecule RNA-Binding Sites in Cells Informs an Isoform-Specific Degrader of QSOX1 mRNA.
J Am Chem Soc
; 144(26): 11620-11625, 2022 07 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-35737519
11.
Hepatic PTEN Signaling Regulates Systemic Metabolic Homeostasis through Hepatokines-Mediated Liver-to-Peripheral Organs Crosstalk.
Int J Mol Sci
; 23(7)2022 Apr 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-35409319
12.
The Pseudo-Natural Product Rhonin Targets RHOGDI.
Angew Chem Int Ed Engl
; 61(18): e202115193, 2022 04 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-35170181
13.
Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway.
J Am Chem Soc
; 143(48): 20332-20342, 2021 12 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34817176
14.
Total Synthesis and Target Identification of the Curcusone Diterpenes.
J Am Chem Soc
; 143(11): 4379-4386, 2021 03 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-33705657
15.
Reprogramming of Protein-Targeted Small-Molecule Medicines to RNA by Ribonuclease Recruitment.
J Am Chem Soc
; 143(33): 13044-13055, 2021 08 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-34387474
16.
Dichloro Butenediamides as Irreversible Site-Selective Protein Conjugation Reagent.
Angew Chem Int Ed Engl
; 60(44): 23750-23755, 2021 10 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-34472678
17.
Chemoproteomics-Enabled De Novo Discovery of Photoswitchable Carboxylesterase Inhibitors for Optically Controlled Drug Metabolism.
Angew Chem Int Ed Engl
; 60(6): 3071-3079, 2021 02 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33035395
18.
S100A11/ANXA2 belongs to a tumour suppressor/oncogene network deregulated early with steatosis and involved in inflammation and hepatocellular carcinoma development.
Gut
; 69(10): 1841-1854, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31919231
19.
Targeted Degradation of the Oncogenic MicroRNA 17-92 Cluster by Structure-Targeting Ligands.
J Am Chem Soc
; 142(15): 6970-6982, 2020 04 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32233464
20.
Ethynylation of Cysteine Residues: From Peptides to Proteins in Vitro and in Living Cells.
Angew Chem Int Ed Engl
; 59(27): 10961-10970, 2020 06 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-32233093