Detalhe da pesquisa
1.
Monoclonal antibody targeting of fibroblast growth factor receptor 1c causes cardiac valvulopathy in rats.
Toxicol Appl Pharmacol
; 355: 147-155, 2018 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30008375
2.
Input estimation for drug discovery using optimal control and Markov chain Monte Carlo approaches.
J Pharmacokinet Pharmacodyn
; 43(2): 207-21, 2016 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-26932466
3.
Elevated Adipocyte Membrane Phospholipid Saturation Does Not Compromise Insulin Signaling.
Diabetes
; 72(10): 1350-1363, 2023 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36580483
4.
Inhibition of SGLT2 Preserves Function and Promotes Proliferation of Human Islets Cells In Vivo in Diabetic Mice.
Biomedicines
; 10(2)2022 Jan 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-35203411
5.
TLCD1 and TLCD2 regulate cellular phosphatidylethanolamine composition and promote the progression of non-alcoholic steatohepatitis.
Nat Commun
; 13(1): 6020, 2022 10 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-36241646
6.
Human genetics uncovers MAP3K15 as an obesity-independent therapeutic target for diabetes.
Sci Adv
; 8(46): eadd5430, 2022 11 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-36383675
7.
PPARγ and PPARα synergize to induce robust browning of white fat in vivo.
Mol Metab
; 36: 100964, 2020 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32248079
8.
Pnpla3 silencing with antisense oligonucleotides ameliorates nonalcoholic steatohepatitis and fibrosis in Pnpla3 I148M knock-in mice.
Mol Metab
; 22: 49-61, 2019 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30772256
9.
IDOL regulates systemic energy balance through control of neuronal VLDLR expression.
Nat Metab
; 1(11): 1089-1100, 2019 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32072135
10.
Opposing effects of adiponectin receptors 1 and 2 on energy metabolism.
Diabetes
; 56(3): 583-93, 2007 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-17327425
11.
The role of mitochondrial glycerol-3-phosphate acyltransferase-1 in regulating lipid and glucose homeostasis in high-fat diet fed mice.
Biochem Biophys Res Commun
; 369(4): 1065-70, 2008 May 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-18339309
12.
Hepatic PGC-1beta overexpression induces combined hyperlipidemia and modulates the response to PPARalpha activation.
Arterioscler Thromb Vasc Biol
; 27(12): 2707-13, 2007 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-17932310
13.
Secretagogin is increased in plasma from type 2 diabetes patients and potentially reflects stress and islet dysfunction.
PLoS One
; 13(4): e0196601, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-29702679
14.
Liver-directed overexpression of mitochondrial glycerol-3-phosphate acyltransferase results in hepatic steatosis, increased triacylglycerol secretion and reduced fatty acid oxidation.
FASEB J
; 20(3): 434-43, 2006 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-16507761
15.
The acute glucose lowering effect of specific GPR120 activation in mice is mainly driven by glucagon-like peptide 1.
PLoS One
; 12(12): e0189060, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-29206860
16.
Hyperglycemia Induced by Glucokinase Deficiency Accelerates Atherosclerosis Development and Impairs Lesion Regression in Combined Heterozygous Glucokinase and the Apolipoprotein E-Knockout Mice.
J Diabetes Res
; 2016: 8630961, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27774459
17.
Studies of nontarget-mediated distribution of human full-length IgG1 antibody and its FAb fragment in cardiovascular and metabolic-related tissues.
J Pharm Sci
; 104(5): 1825-31, 2015 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-25631774
18.
Monoclonal antibody targeting of fibroblast growth factor receptor 1c ameliorates obesity and glucose intolerance via central mechanisms.
PLoS One
; 9(11): e112109, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-25427253
19.
Adiponectin receptor 2 deficiency results in reduced atherosclerosis in the brachiocephalic artery in apolipoprotein E deficient mice.
PLoS One
; 8(11): e80330, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-24324556
20.
PPARalpha activation increases triglyceride mass and adipose differentiation-related protein in hepatocytes.
J Lipid Res
; 47(2): 329-40, 2006 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-16282640