Association of vitamin d with glycemic control in Saudi patients with type 2 diabetes: A retrospective chart review study in an emerging university hospital.

BACKGROUND: Vitamin D (mainly 25-hydroxyvitamin D, 25[OH]D) has stimulated increasing interest in Saudi Arabia over the current years due to its association with several different chronic diseases such as diabetes. This study aims to ascertain whether the vitamin D level has any influence on glycemic control in Saudi patients with type 2 diabetes (T2DM). METHOD: This retrospective study included 200 patients with T2DM who visited Prince Sattam Bin Abdulaziz University Hospital between January 2015 and December 2015. Venous blood was collected and examined for "serum/plasma levels of 25(OH)D" and related variables using kit methods. HbA1C levels <7% and ≥7% were taken as indicators of good and poor glycemic control, respectively. An association between vitamin D deficiency and poor glycemic control was determined using multinomial logistic regression analysis. RESULTS: Among the total of 200 patients with type 2 diabetes, 118 (59%) were female and 82 (41%) were males with the mean age 42.4 ± 14.8 years. Good glycemic control (HbA1c < 7) was observed in 127 (63.5%), and poor glycemic control (HbA1c > 7) was found in 73(36.5%). The mean serum 25(OH)vit D was 20.27 ± 8.66 ng/mL, with (52% vs 82%; P ≤ .001) of subjects identified to have vitamin D deficiency in good and poor glycemic control groups, respectively. CONCLUSION: Taken together, our results demonstrated an association of vitamin D level with poor glycemic control in patients with type 2 diabetes. However, additional studies with larger sample size from local population are warranted in future to confirm and extend the findings of the present study.

The frequency of occurrence of Hepatocellular Carcinoma after direct antiviral therapy in Hepatitis C virus patients.

OBJECTIVE: To study the frequency of occurrence of hepatocellular carcinoma (HCC) in hepatitis C virus patients treated with direct acting antiviral (DAA) agents. METHODS: This hospital based cross-sectional study was conducted in Mayo Hospital, Lahore from June, 2016 to January, 2018. Total 300 patients with HCV genotype 3, selected via Non-Probability Purposive Sampling technique, without prior or concurrent history of HCC, were given DAA agents and were followed up for 6 months after completion of therapy. Results were based on Quantitative PCR to assess Sustained Virological Response (SVR) and Ultrasound Abdomen to look for the appearance of any new lesion. Data was presented as mean ±SD, frequency and percentages and was analyzed using SPSS Version 24.0. RESULTS: Out of 300 patients, 179 (59.7%) were males and 121(40.3%) were females. Mean age of the patients was 55.08 ± 5.602 years. 214(71.3%) patients had compensated cirrhosis at the start of treatment and 86(28.7%) had decompensated cirrhosis. SVR was achieved in 200(93.4%) out of 214 patients with compensated cirrhosis and in 76(88.3%) out of 86 patients with decompensated cirrhosis. At six months post- treatment, 10(3.33%) patients developed HCC,2(0.7%) in the compensated group and 8(2.7%) in the decompensated group, out of which 5(6.6%) patients had achieved SVR. CONCLUSION: The frequency of HCC following DAA agents is significant (3.3%) even after achieving SVR. Caution must be exercised in prescribing DAA agents to HCV patients keeping this complication of HCC in mind.

User Acceptance Level of and Attitudes towards Telemedicine in the United Arab Emirates: A quantitative study.

OBJECTIVES: This study aimed to examine acceptance levels of and attitudes towards telemedicine among users in the United Arab Emirates (UAE) and assess associations between perceived usefulness (PU), perceived ease of use (PEOU), attitudes towards use (ATU) and behavioural intention of use (BIU) in relation to telemedicine technology. METHODS: This cross-sectional study used a simple random sampling design to obtain an appropriate sample from throughout the UAE. The technology acceptance model (TAM) and Rogers' diffusion of innovations (DOI) theory were applied as the conceptual basis for this study. An Arabic/English version of the questionnaire was distributed via email to physicians and nurses, members of the public (including patients), healthcare directors and information technology professionals. Data were collected from 1st March to 30th August 2019 and analysed using Statistical Package for the Social Sciences (SPSS). RESULTS: A total of 330 participants were included (response rate: 85.7%). BIU and PU were considered important elements of TAM in the adoption of telemedicine services compared to the other variables. The association between PEOU (beta = 0.033, P = 0.692), PU (beta = 0.034; P = 0.679) and ATU (beta = 0.055; P = 0.421) in relation to telemedicine were positive but not significant. However, BIU was found to be a strong significant predictor of actual usage (beta = 0.224; P = 0.003). CONCLUSION: This study confirms TAM's applicability in the adoption of telemedicine services in the UAE. The results show that users' perceptions were significantly related to their behavioural intention to use telemedicine. Factors influencing telemedicine technology are likely to vary as technology acceptance in other geographical areas may differ from the sample presented here.