RESUMO
The national neonatal screening programme in the United Arab Emirates currently includes 16 disorders: congenital hypothyroidism, sickle-cell diseases, congenital adrenal hyperplasia, biotinidase deficiency and 12 amino acid, organic acid and fatty acid disorders. This paper reports data since the programme started in January 1995 up to December 2011 on the incidence of screened disorders and the molecular basis of positive screened cases. Screening used a combination of tandem mass spectrometry, molecular technologies and biochemical analysis. A total of 750 365 infants were screened and 717 babies saved from associated morbidity and/or mortality. The incidence of screened disorders were 1:1 873 for congenital hypothyroidism, 1:14 544 for phenylketonuria, 1:3 526 for amino acid, organic acid and fatty acid disorders, 1:9 030 for classical congenital adrenal hyperplasia, 1:8 300 for biotinidase deficiency, 1:2 384 for sickle-cell disease and 1:121 for sickle-cell traits. Coverage of neonatal screening in the population reached 95% in 2010.
Assuntos
Doenças do Recém-Nascido/diagnóstico , Programas de Rastreamento/organização & administração , Programas Nacionais de Saúde/organização & administração , Triagem Neonatal/organização & administração , Feminino , Humanos , Recém-Nascido , Doenças do Recém-Nascido/epidemiologia , Masculino , Desenvolvimento de Programas , Emirados Árabes Unidos/epidemiologiaRESUMO
In January 2002, a pilot programme of neonatal screening for sickle cell disease was launched in the United Arab Emirates (UAE) in 3 districts of Abu Dhabi emirate. This paper reports the incidence of sickle cell diseases, other haemoglobinopathies and haemoglobinopathy carriers over a 12-month period using high performance liquid chromatography as a primary screening method. The overall incidence of sickle cell disease among 22 200 screened neonates was 0.04% (0.07% for UAE citizens and 0.02% for non-UAE citizens). The incidence of sickle cell trait was 1.1% overall (1.5% for UAE citizens and 0.8% for non-UAE citizens). Universal neonatal screening for sickle cell haemoglobin at the national level should be considered.
Assuntos
Anemia Falciforme , Testes Genéticos , Hemoglobinopatias , Triagem Neonatal , Anemia Falciforme/diagnóstico , Anemia Falciforme/epidemiologia , Anemia Falciforme/genética , Coeficiente de Natalidade , Cromatografia Líquida de Alta Pressão , Seguimentos , Aconselhamento Genético , Testes Genéticos/métodos , Testes Genéticos/estatística & dados numéricos , Necessidades e Demandas de Serviços de Saúde , Doença da Hemoglobina C/diagnóstico , Doença da Hemoglobina C/epidemiologia , Doença da Hemoglobina C/genética , Hemoglobina E , Hemoglobinopatias/diagnóstico , Hemoglobinopatias/epidemiologia , Hemoglobinopatias/genética , Hemoglobinas Anormais , Heterozigoto , Humanos , Incidência , Recém-Nascido , Triagem Neonatal/métodos , Triagem Neonatal/estatística & dados numéricos , Projetos Piloto , Vigilância da População , Diagnóstico Pré-Natal , Características de Residência/estatística & dados numéricos , Fatores de Risco , Traço Falciforme/diagnóstico , Traço Falciforme/epidemiologia , Traço Falciforme/genética , Talassemia/diagnóstico , Talassemia/epidemiologia , Talassemia/genética , Emirados Árabes Unidos/epidemiologiaRESUMO
The National Congenital Anomalies Register is a population-based register covering all births in the United Arab Emirates. We evaluated the progress of the register and determined the prevalence of congenital anomalies (CAs) and associated maternal and neonatal risk factors. Total prevalence of CAs for 1999-2001 was 7.89/1000, 10.95/1000 and 7.92/1000 for live births, stillbirths and total births respectively. Rates were comparable to international rates for all districts except Dubai, Fujairah and Ras Al Khaimah. According to the International classification of diseases, the cardiovascular system was the most affected followed by CAs of chromosomal origin and the musculo-skeletal system. Birth defects were more common with older maternal age, grand multiparity, male babies, low-birth-weight babies and premature babies.
Assuntos
Anormalidades Congênitas/epidemiologia , Vigilância da População , Sistema de Registros , Distribuição por Idade , Coeficiente de Natalidade , Peso ao Nascer , Aberrações Cromossômicas/estatística & dados numéricos , Anormalidades Congênitas/classificação , Anormalidades Congênitas/etiologia , Anormalidades Congênitas/prevenção & controle , Consanguinidade , Feminino , Idade Gestacional , Humanos , Recém-Nascido , Classificação Internacional de Doenças , Masculino , Idade Materna , Paridade , Vigilância da População/métodos , Gravidez , Resultado da Gravidez/epidemiologia , Prevalência , Prevenção Primária , Características de Residência , Fatores de Risco , Distribuição por Sexo , Natimorto/epidemiologia , Emirados Árabes Unidos/epidemiologiaRESUMO
This paper reports on health for all in the United Arab Emirates. The current situation in the country regarding health for all and primary health care is described as well as the progress that has been made in this area. The main primary health care programmes and future activities are outlined.
Assuntos
Acessibilidade aos Serviços de Saúde/organização & administração , Programas Nacionais de Saúde/organização & administração , Atenção Primária à Saúde/organização & administração , Previsões , Prioridades em Saúde , Pesquisa sobre Serviços de Saúde , Indicadores Básicos de Saúde , Humanos , Avaliação das Necessidades/organização & administração , Emirados Árabes UnidosRESUMO
The United Arab Emirates National Screening Programme for Congenital Hypothyroidism was established in January 1998. The programme measures neonatal thyroid-stimulating hormone (TSH) levels of blood samples collected on filter paper on day 5 by heel prick. The prevalence of raised TSH levels (> 5 microU/mL whole blood) during 1998 and 1999 was used to evaluate the degree of iodine-deficiency disorders (IDD) in the population in different regions. The ratio of TSH profile in the present study and goitre rate in schools in a 1994 study were discrepant, although there was good correlation between the ratio of TSH profile and urinary iodine. The prevalence of raised TSH levels was < 3% in the Emirates overall, which is normal, and IDD varied from mild to normal problems in different regions.
Assuntos
Hipotireoidismo/diagnóstico , Hipotireoidismo/epidemiologia , Iodo/deficiência , Testes de Função Tireóidea/métodos , Tireotropina/sangue , Adulto , Criança , Hipotireoidismo Congênito , Bócio Endêmico/epidemiologia , Bócio Endêmico/metabolismo , Indicadores Básicos de Saúde , Inquéritos Epidemiológicos , Humanos , Hipotireoidismo/sangue , Incidência , Recém-Nascido , Iodo/urina , Morbidade , Programas Nacionais de Saúde , Triagem Neonatal/métodos , Triagem Neonatal/normas , Vigilância da População/métodos , Prevalência , Saúde Pública , Valores de Referência , Características de Residência/estatística & dados numéricos , Sensibilidade e Especificidade , Testes de Função Tireóidea/normas , Emirados Árabes Unidos/epidemiologiaRESUMO
To evaluate the United Arab Emirate National Newborn Screening Programme we compared coverage, timeliness of programme indicators (age at sampling, recall and treatment initiation, timing of specimen delivery and laboratory results) and specimen quality with international standards. Recall rate, sensitivity, specificity, positive predictive values and relative incidence rates for phenylketonuria (PKU) and congenital hypothyroidism (CH) were calculated. Investigations for hypothyroidism included thyroid function studies (T3, T4, fT4 and TSH), technetium-99m thyroid scan when possible and thyroglobulin and thyroid antibodies when indicated. PKU investigations included plasma amino acids and measurement of biopterin defects. In the 6 years before December 2000, 138,718 neonates were screened. Relative incidences for CH and for classic PKU were 1:1570 and 1:20,050 respectively.
Assuntos
Triagem Neonatal/organização & administração , Assistência ao Convalescente/normas , Fatores Etários , Aminoácidos/sangue , Biopterinas/sangue , Coeficiente de Natalidade , Coleta de Amostras Sanguíneas/normas , Hipotireoidismo Congênito , Necessidades e Demandas de Serviços de Saúde , Humanos , Hipotireoidismo/sangue , Hipotireoidismo/diagnóstico , Hipotireoidismo/epidemiologia , Incidência , Recém-Nascido , Fenilcetonúrias/sangue , Fenilcetonúrias/diagnóstico , Fenilcetonúrias/epidemiologia , Avaliação de Programas e Projetos de Saúde , Indicadores de Qualidade em Assistência à Saúde/normas , Padrões de Referência , Sensibilidade e Especificidade , Tecnécio , Tireoglobulina/sangue , Testes de Função Tireóidea , Fatores de Tempo , Emirados Árabes Unidos/epidemiologiaRESUMO
We investigated the association of biological, sociocultural and economic risk factors with child mortality in Abu Dhabi from 1 January-31 December 1997. With McNemar chi-squared test, most selected biological risk factors were statistically associated with child mortality, although maternal age older than 40 years and history of fetal death were not positively correlated with neonate, infant or age under 5 mortality. Among sociocultural and economic risk factors, maternal lack of formal education and low monthly income were significantly associated with child death. Consanguinity was significantly associated with under 5 and infant but not neonatal mortality. Gestation <37 weeks was highly associated with mortality among all ages. Strengthening health care programmes and emphasizing the need to identify high risk groups should be priorities.
Assuntos
Mortalidade da Criança , Mortalidade Infantil , Saúde da População Urbana/estatística & dados numéricos , Distribuição por Idade , Análise de Variância , Ordem de Nascimento , Distribuição de Qui-Quadrado , Pré-Escolar , Consanguinidade , Escolaridade , Idade Gestacional , Necessidades e Demandas de Serviços de Saúde , Humanos , Lactente , Recém-Nascido , Modelos Logísticos , Idade Materna , Mães/educação , Paridade , Vigilância da População , Sistema de Registros , Fatores de Risco , Fatores Socioeconômicos , Inquéritos e Questionários , Emirados Árabes UnidosAssuntos
Anormalidades Congênitas/epidemiologia , Demografia , Adulto , Coeficiente de Natalidade , Causas de Morte , Anormalidades Congênitas/genética , Anormalidades Congênitas/mortalidade , Consanguinidade , Feminino , Humanos , Lactente , Mortalidade Infantil , Recém-Nascido , Idade Materna , Pessoa de Meia-Idade , Gravidez , Emirados Árabes Unidos/epidemiologiaAssuntos
Causas de Morte , Adolescente , Adulto , Idoso , Feminino , Humanos , Pessoa de Meia-Idade , Emirados Árabes Unidos/epidemiologiaRESUMO
The national neonatal screening programme in the United Arab Emirates currently includes 16 disorders: congenital hypothyroidism, sickle-cell diseases, congenital adrenal hyperplasia, biotinidase deficiency and 12 amino acid, organic acid and fatty acid disorders. This paper reports data since the programme started in January 1995 up to December 2011 on the incidence of screened disorders and the molecular basis of positive screened cases. Screening used a combination of tandem mass spectrometry, molecular technologies and biochemical analysis. A total of 750 365 infants were screened and 717 babies saved from associated morbidity and/or mortality. The incidence of screened disorders were 1:1 873 for congenital hypothyroidism, 1:14 544 for phenylketonuria, 1:3 526 for amino acid, organic acid and fatty acid disorders, 1:9 030 for classical congenital adrenal hyperplasia, 1:8 300 for biotinidase deficiency, 1:2 384 for sickle-cell disease and 1:121 for sickle-cell traits. Coverage of neonatal screening in the population reached 95% in 2010
RESUMO
The National Congenital Anomalies Register is a population-based register covering all births in the United Arab Emirates. We evaluated the progress of the register and determined the prevalence of congenital anomalies [CAs] and associated maternal and neonatal risk factors. Total prevalence of CAs for 1999-2001 was 7.89/1000, 10.95/1000 and 7.92/1000 for live births, stillbirths and total births respectively. Rates were comparable to international rates for all districts except Dubai, Fujairah and Ras Al Khaimah. According to the International classification of diseases, the cardiovascular system was the most affected followed by CAs of chromosomal and the musculo-skeletal system. Birth defects were more common with older maternal age, gr and multiparity, male babies, low-birth-weight babies and premature babies
Assuntos
Distribuição por Idade , Coeficiente de Natalidade , Peso ao Nascer , Aberrações Cromossômicas , Consanguinidade , Idade Gestacional , Anormalidades CongênitasRESUMO
In January 2002, a pilot programme of neonatal screening for sickle cell disease was launched in the United Arab Emirates [UAE] in 3 districts of Abu Dhabi emirate. This paper reports the incidence of sickle cell diseases, other haemoglobinopathies and haemoglobinopathy carriers over a 12-month period using high performance liquid chromatography as a primary screening method. The overall incidence of sickle cell disease among 22 200 screened neonates was 0.04% [0.07% for UAE citizens and 0.02% for non-UAE citizens]. The incidence of sickle cell trait was 1.1% overall [1.5% for UAE citizens and 0.8% for non-UAE citizens]. Universal neonatal screening for sickle cell haemoglobin at the national level should be considered
Assuntos
Coeficiente de Natalidade , Cromatografia Líquida , Seguimentos , Aconselhamento Genético , Doença da Hemoglobina C , Anemia FalciformeRESUMO
This paper reports on health for all in the United Arab Emirates. The current situation in the country regarding health for all and primary health care is described as well as the progress that has been made in this area. The main primary health care programmes and future activities are outlined
Assuntos
Previsões , Prioridades em Saúde , Acessibilidade aos Serviços de Saúde , Pesquisa sobre Serviços de Saúde , Indicadores Básicos de Saúde , Programas Nacionais de Saúde , Avaliação das Necessidades , Atenção Primária à SaúdeRESUMO
We investigated the association of biological, sociocultural and economic risk factors with child mortality in Abu Dhabi from 1 January-31 December 1997. With McNemar chi-squared test, most selected biological risk factors were statistically associated with child mortality, although maternal age older than 40 years and history of fetal death were not positively correlated with neonate, infant or age under 5 mortality. Among sociocultural and economic risk factors, maternal lack of formal education and low monthly income were significantly associated with child death. Consanguinity was significantly associated with under 5 and infant but not neonatal mortality. Gestation <37 weeks was highly associated with mortality among all ages. Strengthening health care programmes and emphasizing the need to identify high risk groups should be priorities
Assuntos
Distribuição por Idade , Análise de Variância , Ordem de Nascimento , Distribuição de Qui-Quadrado , Pré-Escolar , Consanguinidade , Escolaridade , Idade Gestacional , Mortalidade Infantil , Idade Materna , Mortalidade da CriançaRESUMO
To evaluate the United Arab Emirate National Newborn Screening Programme we compared coverage, timeliness of programme indicators [age at sampling, recall and treatment initiation, timing of specimen delivery and laboratory results] and specimen quality with international st and ards. Recall rate, sensitivity, specificity, positive predictive values and relative incidence rates for phenylketonuria [PKU] and congenital hypothyroidism [CH] were calculated. Investigations for hypothyroidism included thyroid function studies [T3, T4, fT4 and TSH], technetium-99m thyroid scan when possible and thyroglobulin and thyroid antibodies when indicated. PKU investigations included plasma amino acids and measurement of biopterin defects. In the 6 years before December 2000, 138,718 neonates were screened. Relative incidences for CH and for classic PKU were 1:1570 and 1:20,050 respectively
Assuntos
Assistência ao Convalescente , Fatores Etários , Aminoácidos , Biopterinas , Coeficiente de Natalidade , Hipotireoidismo Congênito , Necessidades e Demandas de Serviços de Saúde , Hipotireoidismo , Recém-Nascido , Triagem NeonatalRESUMO
The United Arab Emirates National Screening Programme for Congenital Hypothyroidism was established in January 1998. The programme measures neonatal thyroid-stimulating hormone [TSH] levels of blood samples collected on filter paper on day 5 by heel prick. The prevalence of raised TSH levels [> 5 microU/mL whole blood] during 1998 and 1999 was used to evaluate the degree of iodine-deficiency disorders [IDD] in the population in different regions. The ratio of TSH profile in the present study and goitre rate in schools in a 1994 study were discrepant, although there was good correlation between the ratio of TSH profile and urinary iodine. The prevalence of raised TSH levels was < 3% in the Emirates overall, which is normal, and IDD varied from mild to normal problems in different regions